Substituted azepino[2,1-a]isoquinoline compounds

Claim 1

A compound of the formula ##STR60## including a pharmaceutically acceptable salt thereof wherein: A is ##STR61## R 1 and R 12 are independently selected from the group consisting of hydrogen, alkyl, alkenyl, cycloalkyl, substituted alkyl, substituted alkenyl, aryl, substituted aryl, heteroaryl, cycloalkyl- alkylene-, aryl-alkylene-, substituted aryl-alkylene-, and heteroaryl-alkylene- or R 1 and R 12 taken together with the carbon to which they are attached complete a cycloalkyl ring or a benzofused cycloalkyl ring; R 2 is hydrogen, ##STR62## or R 11 --S--; R 3 , R 5 and R 7 are independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, aryl--(CH 2 ) p --, substituted aryl --(CH 2 ) p --, heteroaryl--(CH 2 ) p --, ##STR63## R 4 is alkyl, cycloalkyl--(CH 2 ) p --, substituted alkyl, aryl--(CH 2 ) p --, substituted aryl--(CH 2 ) p --, or heteroaryl--(CH 2 ) p --; R 6 is alkyl, substituted alkyl, cycloalkyl--(CH 2 ) p --, aryl--(CH 2 ) p --, substituted aryl--(CH 2 ) p --, or heteroaryl--(CH 2 ) p --; R 8 is hydrogen, lower alkyl, cycloalkyl, or phenyl; R 9 is hydrogen, lower alkyl, lower alkoxy, or phenyl; R 10 is lower alkyl or aryl--(CH 2 ) p --; R 11 is alkyl, substituted alkyl, cycloalkyl--(CH 2 ) p --, aryl--(CH 2 ) p --, substituted aryl--(CH 2 ) p --, heteroaryl--(CH 2 ) p --, or --S--R 11 completes a symmetrical disulfide wherein R 11 is ##STR64## X 1 and X 2 are independently selected from the group consisting of hydrogen, lower alkyl, lower alkoxy, lower alkylthio, halo, trifluoromethyl, hydroxy, amino, --NH(lower alkyl), --N(lower alkyl) 2 , cycloalkyl--(CH 2 ) p --, and aryl--(CH 2 ) p --, or X 1 and X 2 are on adjacent carbons and are joined to complete a benzene ring or are joined to complete --O--(CH 2 ) m --O-- wherein m is one or two; n is zero or one; p is zero or an integer from 1 to 6; and q is zero or an integer from 1 to 3.