US5225401A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Treatment of congestive heart failure
Assignee: ER Squibb and Sons LLC
•
Filing: 1991-08-12
•
Granted: 1993-07-06
•
Expires: 2011-08-12
Abstract
Abstract Congestive heart failure is treated by administration of a selective inhibitor of neutral endopeptidase and an angiotensin converting enzyme inhibitor. Captopril, fosinopril sodium, enalapril maleate and lisinopril are the preferred angiotensin converting enzyme inhibitors and the mercapto compounds of the formula ##STR1## are the preferred selective inhibitors of neutral endopeptidase.
Inventors
- 👤 Andrea A. Seymour
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 19:41
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/16; A61K31/165; A61K45/00; A61K45/06; A61K31/185; A61K31/19; A61K31/195; A61K31/33; A61K31/395; A61K31/40; A61K31/66; A61K31/675; A61K38/00; A61K38/16; A61K38/55; A61K38/556; A61P; A61P43/00; A61P9/00; A61P9/04
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
75 words
A method of treating a mammalian specie suffering from congestive heart failure comprising administering an effective amount of a selective inhibitor of neutral endopeptidase of the formula ##STR6## wherein n is an integer from 1 to 9 and an effective amount of an angiotensin converting enzyme inhibitor selected from the group consisting of captopril, fosinopril sodium, enalapril maleate, and lisinopril, said inhibitors being administered concurrently or at an interval of up to about 4 hours.
Claim 2
Independent Claim
75 words
A method of treating a mammalian specie suffering from congestive heart failure comprising administering an effective amount of a selective inhibitor of neutral endopeptidase of the formula ##STR6## wherein n is an integer from 1 to 9 and an effective amount of an angiotensin converting enzyme inhibitor selected from the group consisting of captopril, fosinopril sodium, enalapril maleate, and lisinopril, said inhibitors being administered concurrently or at an interval of up to about 4 hours.
Claim 3
Dependent Claim
22 words
The method of claim 1 wherein the selective inhibitor of neutral endopeptidase is ##STR7## and the angiotensin converting enzyme inhibitor is captopril.
Claim 4
Dependent Claim
26 words
The method of claim 1 wherein the selective inhibitor of neutral endopeptidase and the angiotensin converting enzyme inhibitor are administered concurrently from a single dose form.
Claim 5
Dependent Claim
25 words
The method of claim 1 wherein the selective inhibitor of neutral endopeptidase and the angiotensin converting enzyme inhibitor are administered concurrently from separate dosage forms.
Claim 6
Dependent Claim
27 words
The method of claim 1 wherein the selective inhibitor of neutral endopeptidase and the angiotensin converting enzyme inhibitor are administered separately up to about 4 hours apart.
Claim 7
Dependent Claim
60 words
The method of claim 1 wherein the selective inhibitor of neutral endopeptidase is administered at a dosage range of from about 0.03 to about 1000 mg. per kg. of body weight per day and the angiotensin converting enzyme inhibitor is administered at a dosage range of from about 0.001 to about 50 mg. per kg. of body weight per day.
Claim 8
Dependent Claim
60 words
The method of claim 6 wherein the selective inhibitor of neutral endopeptidase is administered at a dosage range of from about 0.3 to about 300 mg. per kg. of body weight per day and the angiotensin converting enzyme inhibitor is administered at a dosage range of from about 0.1 to about 10 mg. per kg. of body weight per day.
References Cited (Backward Citations)
US4818749A
Cited
US4906615A
Cited
US4722810A
Cited
US4826816A
Cited
US4749688A
Cited
US4801609A
Cited
US4801609B1
Cited
GB2207351A
Cited
EP0361365A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-07-05 | 1997-01-04 | 1997-07-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-07-05 | 2001-01-04 | 2001-07-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-07-05 | 2005-01-04 | 2005-07-06 | $7700.00 | Window Closed / Lapsed |