Antihypertensive compounds

Claim 1

A compound represented by the formula ##STR32## and the pharmaceutically acceptable salts thereof, wherein: A is ##STR33## l is 1 or 2; n is 0 or 1; p and q are 0, 1 or 2, provided that in structurces IIb and IIc the sum of p and q is 1 or 2, and that in formula IId, p is not 0; B is --[J]--[L]--[M]--; D is ##STR34## E is --NH--, --O--, --S--, or --CH 2 --; G is --SO 2 --; J is --(CH 2 ) s -- or --((CH 2 ) t --W)--; L is a chemical bond, cis- or trans-lower alkene, lower alkyne, -Z-aryl-, -aryl-Z-, -Z-cycloalkyl-, or -cycloalyl-Z-, wherein aryl is ##STR35## and cycloalkyl is ##STR36## wherein w is 1, 2 or 3; M is --(CH 2 ) u -- or --((CH 2 ) t --X--(CH 2 ) v )--; W is ##STR37## X and Z are independently a chemical bond, ##STR38## s, u and v are independently 0-5; t is 1-5; R 1 , R 2 and R 9 are independently hydrogen, lower alkyl or lower acyl; R 3 is 2-, 3- or 4-pyridylloweralkyl, 2-, 4- or 5-thiazolylloweralkyl, 2-, 4- or 5-1H-imidazolylloweralkyl, 1-imidazolylloweralkyl, 1-morpholinoloweralkyl or hydroxyphenylloweralkyl; R 4 is chlorine or CF 3 ; R 5 is hydrogen, halogen, lower alkyl, lower acyl, lower alkoxy, haloloweralkyl or phenylloweralkyl; R 7 is hydrogen, lower alkyl or aminoloweralkyl; R 6 and R 8 are independently hydroxy, alkoxy having from 1 to 8 carbon atoms, benzyl, allyl, R 10 --Q r --(CH 2 ) m --O--, wherein Q is oxygen or sulfur, r is 0 or 1 and m is 2 to 4, ##STR39## wherein the alkyl has from 3 to 8 carbon atoms, ##STR40## wherein the phenyl may be substituted with group T defined below, 1-glyceryl, ##STR41## R 10 is phenyl, substituted phenyl wherein the substituents are chosen from group T, 1-naphthyl or 2-naphthyl; T is halogen, hydroxy, trifluoromethyl, lower alkoxy, lower alkyl, 2-furanyl, 3-furanyl, 2-thienyl, 3-thienyl, phenyl and substituted phenyl wherein the substituents are chosen from halogen, hydroxy, trifluoromethyl, lower alkoxy or lower alkyl; R 11 is hydrogen or alkyl having from 1 to 8 carbon atoms; R 12 is hydrogen, lower alkyl, unsubstituted or substituted phenyl and substituted or unsubstituted phenyl lower alkyl, wherein phenyl may be substituted by group T; R 13 is hydrogen or lower alkyl; and provided that if L is alkene or alkyne, J is --(CH 2 ) s -- wherein is 1-5; provided that if L is --Z--aryl-- or --Z--cycloalkyl--, J is --(CH 2 ) s -- wherein s is 2-5; provided that if L is alkene, alkyne, --aryl--Z-- or --cycloalkyl--Z--, M is --(CH 2 ) u -- wherein u is 1-5; provided that if s and u are each zero, L is aryl or cycloalkyl (i.e. Z is a bond); and provided that if s and v are each zero, L is aryl or cycloakyl (i.e. Z is a bond).