US5618850A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Hydroxy-acid cosmetics
Assignee: Genzyme Corp
•
Filing: 1995-03-09
•
Granted: 1997-04-08
•
Expires: 2015-03-09
Abstract
Abstract A method for alleviating the symptoms of a cosmetic or dermatologic skin condition is described. An effective amount of a poly(hydroxy acid)/polymer conjugate in a pharmaceutically or cosmetically acceptable vehicle is provided. Topical compositions of the conjugates with another cosmetic or dermatological agent, and compounds of the conjugates having attached physiologically active functional groups, are also provided.
Inventors
- 👤 Arthur J. Coury
- 👤 Luis Z. Avila
- 👤 Chandrashekhar P. Pathak
- 👤 Shikha P. Barman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 06:03
CPC Classifications
A; A61; A61Q; A61Q19/00; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/33; A61K8/36; A61K8/365; A61K8/67; A61K8/671; A61K8/72; A61K8/73; A61K8/731; A61K8/735; A61K8/84; A61K8/85; A61K8/86; A61K8/90; A61P; A61P1/00; A61P17/00; A61P25/00; A61P25/02; A61P29/00; A61P3/00; A61P3/02; A61P31/00; A61P31/04; A61P33/00; A61P33/10; A61P43/00; A61K2800/00; A61K2800/40; A61K2800/57; A61Q17/00; A61Q17/04; A61Q19/007; A61Q19/02; A61Q19/08; A61Q5/00; A61Q5/006
Claims Analysis
Total Claims: 39
Claim 1
Independent Claim
132 words
A method for conditioning skin or alleviating the symptoms of a cosmetic or dermatologic skin condition, the method comprising topically applying an effective amount of a composition comprising a hydroxy acid copolymer in combination with a suitable carrier for topical application to skin in need of treatment thereof, wherein the hydroxy acid copolymer comprises polymerized hydroxy acids covalently joined to a polymer block, and wherein the hydroxy acid copolymer has the formula PaHb, wherein P is a hydrophilic polymer block consisting predominantly of non-hydroxy acid subunits, H is a polymer block consisting predominantly of hydroxy acid subunits, a is the number of P blocks, b is the number of H blocks, a and b are integers of at least one, and the copolymer is either a linear, brush, star or branched copolymer.
Claim 2
Independent Claim
132 words
A method for conditioning skin or alleviating the symptoms of a cosmetic or dermatologic skin condition, the method comprising topically applying an effective amount of a composition comprising a hydroxy acid copolymer in combination with a suitable carrier for topical application to skin in need of treatment thereof, wherein the hydroxy acid copolymer comprises polymerized hydroxy acids covalently joined to a polymer block, and wherein the hydroxy acid copolymer has the formula PaHb, wherein P is a hydrophilic polymer block consisting predominantly of non-hydroxy acid subunits, H is a polymer block consisting predominantly of hydroxy acid subunits, a is the number of P blocks, b is the number of H blocks, a and b are integers of at least one, and the copolymer is either a linear, brush, star or branched copolymer.
Claim 3
Dependent Claim
17 words
The method of claim 1 wherein the sum of a and b is less than about 100.
Claim 4
Dependent Claim
29 words
The method of claim 1 wherein the linkages between the hydroxy acid subunits and the polymer backbone are degradable under the conditions present on the skin in the carrier.
Claim 5
Dependent Claim
18 words
The method of claim 1 wherein the hydroxy acid subunits have a molecular weight of 600 or less.
Claim 6
Dependent Claim
25 words
The method of claim 1 wherein the hydroxy acid is selected from the group consisting of glycolic, lactic, hydroxybutyric, hydroxypentanoic, hydroxyhexanoic, carbonic, glyceric and salicylic.
Claim 7
Dependent Claim
22 words
The method of claim 1 wherein the number of hydroxy acid subunits in the hydroxy acid blocks is between one and 100.
Claim 8
Dependent Claim
34 words
The method of claim 1 wherein the backbone polymer comprises subunits selected from the group consisting of alkylene oxides, (meth) acrylates, ethylenes, vinyl alcohols, vinyl acetates, pyrrolidones, oxazolidines, saccharides, amino acids, nucleotides, and phenols.
Claim 9
Dependent Claim
28 words
The method of claim 1 where the backbone polymer is selected from the group consisting of polyalkylene oxide, polyvinyl alcohol, dextran, starch, hyaluronic acid, hydroxyethylcellulose, and polyacrylic acid.
Claim 10
Dependent Claim
18 words
The method of claim 1 wherein the backbone polymer blocks have a molecular weight between 200 and 100,000.
Claim 11
Dependent Claim
54 words
The method of claim 1 wherein the skin to be treated is affected with a condition selected from the group consisting of dry skin, xerosis, ichthyosis, dandruff, pigmented spots, keratoses, melasma, lentigines, blemishes, wrinkles, skin lines, oily skin, ache, warts, eczema, pruritic skin, psoriasis, inflammatory dermatoses, disturbed keratinization, and skin changes associated with aging.
Claim 12
Dependent Claim
39 words
The method of claim 1 wherein the composition further comprises materials selected from the group consisting of antibiotics, antifungals, pediculicides, antiperspirants, antipruritics, analgesics, anesthetics, blister treatments, canker sore treatments, insect bite treatments, diaper rash treatments, insect repellents, and sunscreens.
Claim 13
Dependent Claim
27 words
The method of claim 1 wherein the carrier is selected from the group consisting of powders, solutions, gels, creams, ointments, sticks, emulsions, foams, aerosols, sprays, and lotions.
Claim 14
Dependent Claim
11 words
The method of claim 1 wherein the composition is substantially anhydrous.
Claim 15
Independent Claim
110 words
A method for making a cosmetic composition, comprising mixing one or more hydroxy acid copolymers in combination with a suitable carrier for topical application to skin wherein the hydroxy acid copolymer comprises polymerized hydroxy acids covalently joined to a polymer block and wherein the hydroxy acid copolymers have the formula PaHb, wherein P is a hydrophilic polymer block consisting predominantly of non-hydroxy acid subunits, H is a polymer block consisting predominantly of hydroxy acid subunits, a is the number of P blocks, b is the number of H blocks, a and b are integers of at least one, and the copolymer is either a linear, brush, star or branched copolymer.
Claim 16
Independent Claim
110 words
A method for making a cosmetic composition, comprising mixing one or more hydroxy acid copolymers in combination with a suitable carrier for topical application to skin wherein the hydroxy acid copolymer comprises polymerized hydroxy acids covalently joined to a polymer block and wherein the hydroxy acid copolymers have the formula PaHb, wherein P is a hydrophilic polymer block consisting predominantly of non-hydroxy acid subunits, H is a polymer block consisting predominantly of hydroxy acid subunits, a is the number of P blocks, b is the number of H blocks, a and b are integers of at least one, and the copolymer is either a linear, brush, star or branched copolymer.
Claim 17
Dependent Claim
17 words
The method of claim 14 wherein the sum of a and b is less than about 100.
Claim 18
Dependent Claim
29 words
The method of claim 14 wherein the linkages between the hydroxy acid subunits and the polymer backbone are degradable under the conditions present on the skin in the carrier.
Claim 19
Dependent Claim
18 words
The method of claim 14 wherein the hydroxy acid subunits have a molecular weight of 600 or less.
Claim 20
Dependent Claim
25 words
The method of claim 14 wherein the hydroxy acid is selected from the group consisting of glycolic, lactic, hydroxybutyric, hydroxypentanoic, hydroxyhexanoic, carbonic, glyceric and salicylic.
Claim 21
Dependent Claim
22 words
The method of claim 14 wherein the number of hydroxy acid subunits in the hydroxy acid blocks is between one and 100.
Claim 22
Dependent Claim
34 words
The method of claim 14 wherein the backbone polymer comprises subunits selected from the group consisting of alkylene oxides, (meth) acrylates, ethylenes, vinyl alcohols, vinyl acetates, pyrrolidones, oxazolidines, saccharides, amino acids, nucleotides, and phenols.
Claim 23
Dependent Claim
28 words
The method of claim 14 where the backbone polymer is selected from the group consisting of polyalkylene oxide, polyvinyl alcohol, dextran, starch, hyaluronic acid, hydroxyethylcellulose, and polyacrylic acid.
Claim 24
Dependent Claim
18 words
The method of claim 14 wherein the backbone polymer blocks have a molecular weight between 200 and 100,000.
Claim 25
Dependent Claim
40 words
The method of claim 14 further comprising adding to the composition materials selected from the group consisting of antibiotics, antifungals, pediculicides, antiperspirants, antipruritics, analgesics, anesthetics, blister treatments, canker sore treatments, insect bite treatments, diaper rash treatments, insect repellents, and sunscreens.
Claim 26
Dependent Claim
27 words
The method of claim 14 wherein the carrier is selected from the group consisting of powders, solutions, gels, creams, ointments, sticks, emulsions, foams, aerosols, sprays, and lotions.
Claim 27
Dependent Claim
118 words
A composition for treatment of the skin, comprising an effective amount of a composition comprising one or more hydroxy acid copolymers in combination with a suitable carrier for topical application to skin in need of treatment wherein the hydroxy acid copolymer comprises polymerized hydroxy acids covalently joined to a polymer block, the hydroxy acid copolymer having the formula PaHb, wherein P is a hydrophilic polymer block consisting predominantly of non-hydroxy acid subunits, H is a polymer block consisting predominantly of hydroxy acid subunits, a is the number of P blocks, b is the number of H blocks, a and b are integers of at least one, and the copolymer is either a linear, brush, star or branched copolymer.
Claim 28
Dependent Claim
118 words
A composition for treatment of the skin, comprising an effective amount of a composition comprising one or more hydroxy acid copolymers in combination with a suitable carrier for topical application to skin in need of treatment wherein the hydroxy acid copolymer comprises polymerized hydroxy acids covalently joined to a polymer block, the hydroxy acid copolymer having the formula PaHb, wherein P is a hydrophilic polymer block consisting predominantly of non-hydroxy acid subunits, H is a polymer block consisting predominantly of hydroxy acid subunits, a is the number of P blocks, b is the number of H blocks, a and b are integers of at least one, and the copolymer is either a linear, brush, star or branched copolymer.
Claim 29
Dependent Claim
17 words
The composition of claim 25 wherein the sum of a and b is less than about 100.
Claim 30
Dependent Claim
29 words
The composition of claim 25 wherein the linkages between the hydroxy acid subunits and the polymer backbone are degradable under the conditions present on the skin in the carrier.
Claim 31
Dependent Claim
18 words
The composition of claim 25 wherein the hydroxy acid subunits have a molecular weight of 600 or less.
Claim 32
Dependent Claim
25 words
The composition of claim 25 wherein the hydroxy acid is selected from the group consisting of glycolic, lactic, hydroxybutyric, hydroxypentanoic, hydroxyhexanoic, carbonic, glyceric and salicylic.
Claim 33
Dependent Claim
22 words
The composition of claim 25 wherein the number of hydroxy acid subunits in the hydroxy acid blocks is between one and 100.
Claim 34
Dependent Claim
34 words
The composition of claim 25 wherein the backbone polymer comprises subunits selected from the group consisting of alkylene oxides, (meth) acrylates, ethylenes, vinyl alcohols, vinyl acetates, pyrrolidones, oxazolidines, saccharides, amino acids, nucleotides, and phenols.
Claim 35
Dependent Claim
28 words
The composition of claim 25 where the backbone polymer is selected from the group consisting of polyalkylene oxide, polyvinyl alcohol, dextran, starch, hyaluronic acid, hydroxyethylcellulose, and polyacrylic acid.
Claim 36
Dependent Claim
18 words
The composition of claim 25 wherein the backbone polymer blocks have a molecular weight between 200 and 100,000.
Claim 37
Dependent Claim
39 words
The composition of claim 25 wherein the composition further comprises materials selected from the group consisting of antibiotics, antifungals, pediculicides, antiperspirants, antipruritics, analgesics, anesthetics, blister treatments, canker sore treatments, insect bite treatments, diaper rash treatments, insect repellents, and sunscreens.
Claim 38
Dependent Claim
27 words
The composition of claim 25 wherein the carrier is selected from the group consisting of powders, solutions, gels, creams, ointments, sticks, emulsions, foams, aerosols, sprays, and lotions.
Claim 39
Dependent Claim
11 words
The composition of claim 25 wherein the composition is substantially anhydrous.
References Cited (Backward Citations)
US2726982A
Cited
US2917410A
Cited
US3689531A
Cited
US3755558A
Cited
US3784585A
Cited
US4294852A
Cited
US3988470A
Cited
US4105782A
Cited
US4363815A
Cited
US4380549A
Cited
US4234599A
Cited
US4942035A
Cited
US4526938A
Cited
US4668430A
Cited
US4946824A
Cited
US4673571A
Cited
US4563489A
Cited
US4857602A
Cited
US4882168A
Cited
US5091171A
Cited
US5091171B2
Cited
US5091171B1
Cited
US5258391A
Cited
US4826945A
Cited
EP0358528A2
Cited
US5194253A
Cited
US4883660A
Cited
US5158955A
Cited
US5171264A
Cited
US5208355A
Cited
US5244665A
Cited
WO1993017669A1
Cited
WO1993024476A1
Cited
US5393798A
Cited
US5312437A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2000-04-07 | 2000-10-07 | 2001-04-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2004-04-07 | 2004-10-07 | 2005-04-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2008-04-07 | 2008-10-07 | 2009-04-08 | $7700.00 | Window Closed / Lapsed |