US3988470A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Treatment of palmar and plant disturbed keratosis
Assignee: Individual
•
Filing: 1975-03-07
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Granted: 1976-10-26
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Expires: 1995-03-07
Abstract
Abstract A treatment to alleviate the symptoms of diseases characterized by defects in keratinization consisting of the topical application of an ointment or lotion containing one or more lower aliphatic compounds having from two to about six carbon atoms, and preferably having α-carbon functionality is disclosed. The compounds include α-hydroxy acids, keto acids and esters thereof, and 3-hydroxybutyric acid. The therapeutic composition may include one or more of the compounds present in a total amount of from one to twenty percent in either a water or alcohol solution or an ointment. Topical application to affected areas has been found to achieve a complete remission of dandruff, acne and palmar and plantar hyperkeratosis.
Inventors
- 👤 Eugene J. Van Scott
- 👤 Ruey J. Yu
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 13:24
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/335; A61K31/35; A61K31/185; A61K31/19; A61K31/21; A61K31/215; A61K31/22; A61K8/00; A61K8/18; A61K8/30; A61K8/33; A61K8/36; A61K8/365; A61Q; A61Q19/00; A61Q5/00; A61Q5/006
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
78 words
A method of alleviating the symptoms of palmar keratosis comprising topically applying an effective amount of a medicinal composition to the involved portions of the human body, said composition comprising from about 1 to about 20% by weight of a compound selected from a group consisting of glycolic acid, citric acid, malic acid, tartronic acid, tartaric acid, glucuronic acid, pyruvic acid, ethyl pyruvate, methyl pyruvate, 2-hydroxyisobutyric acid and 3-hydroxy butyric acid in admixture with a pharmaceutically acceptable carrier.
Claim 2
Independent Claim
78 words
A method of alleviating the symptoms of palmar keratosis comprising topically applying an effective amount of a medicinal composition to the involved portions of the human body, said composition comprising from about 1 to about 20% by weight of a compound selected from a group consisting of glycolic acid, citric acid, malic acid, tartronic acid, tartaric acid, glucuronic acid, pyruvic acid, ethyl pyruvate, methyl pyruvate, 2-hydroxyisobutyric acid and 3-hydroxy butyric acid in admixture with a pharmaceutically acceptable carrier.
Claim 3
Dependent Claim
18 words
The method of claim 1 wherein said compound is present in from 5 to about 10% by weight.
Claim 4
Dependent Claim
51 words
The method of claim 1 wherein said composition is an ointment containing said compound dissolved in about 1 to about 30% by volume of a solvent selected from a group consisting of water and ethanol, and admixed with an ointment base selected from the group consisting of petrolatum and hydrophilic ointment.
Claim 5
Dependent Claim
44 words
The method of claim 1 wherein said compound is dissolved in a mixture of water, ethanol, and propylene glycol, said ethanol being present in no more than about 70% by weight and said propylene glycol present in no more than about 30% by weight.
Claim 6
Dependent Claim
23 words
The method of claim 4 wherein said liquid is an admixture of water, ethanol and propylene glycol present in a ratio of 40:40:20.
Claim 7
Independent Claim
78 words
A method of alleviating the symptoms of plantar keratosis comprising topically applying an effective amount of a medicinal composition to the involved portions of the human body, said composition comprising from about 1% to about 2% by weight of a compound selected from the group consisting of glycolic acid, citric acid, malic acid, tartronic acid, tartaric acid, glucuronic acid, pyruvic acid, ethyl pyruvate, methyl pyruvate, 2-hydroxyisobutyric acid, and 3-hydroxy butyric acid in admixture with a pharmaceutically acceptable carrier.
Claim 8
Independent Claim
78 words
A method of alleviating the symptoms of plantar keratosis comprising topically applying an effective amount of a medicinal composition to the involved portions of the human body, said composition comprising from about 1% to about 2% by weight of a compound selected from the group consisting of glycolic acid, citric acid, malic acid, tartronic acid, tartaric acid, glucuronic acid, pyruvic acid, ethyl pyruvate, methyl pyruvate, 2-hydroxyisobutyric acid, and 3-hydroxy butyric acid in admixture with a pharmaceutically acceptable carrier.
Claim 9
Dependent Claim
18 words
The method of claim 6 wherein said compound is present in from 5 to about 10% by weight.
Claim 10
Dependent Claim
51 words
The method of claim 6 wherein said composition is an ointment containing said compound dissolved in about 1 to about 30% by volume of a solvent selected from the group consisting of water and ethanol, and admixed with an ointment base selected from the group consisting of petrolatum and hydrophilic ointment.
Claim 11
Dependent Claim
44 words
The method of claim 6 wherein said compound is dissolved in a mixture of water, ethanol, and propylene glycol, said ethanol being present in nor more than about 70% by weight and said propylene glycol present in no more than about 30% by weight.
Claim 12
Dependent Claim
23 words
The method of claim 9 wherein the liquid is an admixture of water, ethanol, and propylene glycol present in a ratio of 40:40:20.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-10-26 | 1980-04-26 | 1980-10-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-10-26 | 1984-04-26 | 1984-10-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-10-26 | 1988-04-26 | 1988-10-26 | $7700.00 | Window Closed / Lapsed |