Bioabsorbable surgical suture coating

Claim 2

A bioabsorbable coating for a surgical suture or ligature comprising a diblock copolymer having a first block comprising a polyalkylene oxide and a second block consisting essentially of glycolic acid ester and trimethylene carbonate linkages such that said diblock copolymer has a melting point (Tm) less than 65 degrees centigrade and a glass transition temperature (Tg) less than 20 degrees centigrade and is soluble in methylene chloride or chloroform or both.

Claim 3

A coating of claim 1 wherein the polyalkylene oxide block is from 5 to 25 percent by weight of the copolymer.

Claim 4

A coating of claim 1 wherein the number average molecular weight of the polyalkylene oxide block is from about 4,000 to 30,000.

Claim 5

A coating of claim 1 wherein the polyalkylene oxide block is derived from a polyalkylene oxide terminated on one end by a C 1 to C 6 alkyl group and on the other end by a hydroxyl group.

Claim 6

A coating of claim 4 wherein the polyalkylene oxide block is derived from a homopolymer of ethylene oxide.

Claim 7

A coating of claim 4 wherein the polyalkylene oxide block is derived from a block or random copolymer of ethylene oxide and a cyclic ether.

Claim 8

A coating of claim 6 wherein the cyclic ether is selected from the group consisting of ##STR9## wherein x is 2 to about 9, y is 1 to about 9 and R is a C 1 to C 6 alkyl group.

Claim 9

A coating of claim 4 wherein the polyalkylene oxide block is derived from a block or random copolymer of a first cyclic ether selected from the group consisting of ##STR10## wherein x is 2 to about 9, and a second cyclic ether selected from the group consisting of ##STR11## wherein y is 1 to about 9 and R is a C 1 to C 6 alkyl group.

Claim 10

A coating of claim 5 or 7 or 8 wherein the inherent viscosity of the copolymer, as measured at 30° C. for a 0.5% (w/v) solution in chloroform or methylene chloride, is 0.25 to about 1.50 dl/g.

Claim 11

A coating of claim 9 wherein the bioabsorbable surgical suture or ligature is manufactured from a polymer prepared from one or more monomers selected from the group consisting of lactides.

Claim 12

A coating of claim 10 wherein the suture or ligature is manufactured from a homopolymer prepared from the monomer glycolide.

Claim 13

A coating of claim 10 wherein the suture or ligature is manufactured from a copolymer prepared from the monomers glycolide and lactide.

Claim 14

A coating of claim 11 wherein the suture or ligature is in multifilamentary form.

Claim 15

A coating of claim 13 comprising about 1/10 to 5% by weight of the coated suture or ligature.

Claim 16

A coating of claim 14 comprising about 1 to 3% by weight of the coated suture or ligature.

Claim 17

A bioabsorbable coating for a surgical suture or ligature comprising a triblock copolymer having a middle block and two end blocks, the middle block obtained by removing both terminal hydroxyl hydrogens from either a homopolymer of ethylene oxide, or from a block or random copolymer of ethylene oxide and a cyclic ether, and each end block consisting essentially of glycolic acid ester and trimethylene carbonate linkages such that said triblock copolymer has a melting point (Tm) less than 65 degrees centigrade and a glass transition temperature (Tg) less than 20 degrees centigrade and is soluble in methylene chloride or chloroform or both.

Claim 18

A bioabsorbable coating for a surgical suture or ligature comprising a triblock copolymer having a middle block and two end blocks, the middle block obtained by removing both terminal hydroxyl hydrogens from either a homopolymer of ethylene oxide, or from a block or random copolymer of ethylene oxide and a cyclic ether, and each end block consisting essentially of glycolic acid ester and trimethylene carbonate linkages such that said triblock copolymer has a melting point (Tm) less than 65 degrees centigrade and a glass transition temperature (Tg) less than 20 degrees centigrade and is soluble in methylene chloride or chloroform or both.

Claim 19

A coating of claim 16 wherein the cyclic ether is selected from the group consisting of ##STR12## wherein x is 2 to about 9, y is 1 to about 9 and R is a C 1 to C 6 alkyl group.

Claim 20

A coating of claim 17 having a middle block obtained from a block copolymer of ethylene oxide and a cyclic ether of the formula: ##STR13##

Claim 21

A bioabsorbable coating for a surgical suture or ligature comprising a triblock copolymer having a middle block and two end blocks, the middle block obtained by removing both terminal hydroxyl hydrogens from a block or random copolymer of a first cyclic ether selected from the group consisting of ##STR14## wherein x is 2 to about 9, and a second cyclic ether selected from the group consisting of ##STR15## wherein y is 1 to about 9 and R is a C 1 to C 6 alkyl group, and each end block consisting essentially of glycolic acid ester and trimethylene carbonate linkages such that said triblock copolymer has a melting points (Tm) less than 65 degrees centigrade and a glass transition temperature (Tg) less than 20 degrees centigrade and is soluble in methylene chloride and/or chloroform.

Claim 22

A bioabsorbable coating for a surgical suture or ligature comprising a triblock copolymer having a middle block and two end blocks, the middle block obtained by removing both terminal hydroxyl hydrogens from a block or random copolymer of a first cyclic ether selected from the group consisting of ##STR14## wherein x is 2 to about 9, and a second cyclic ether selected from the group consisting of ##STR15## wherein y is 1 to about 9 and R is a C 1 to C 6 alkyl group, and each end block consisting essentially of glycolic acid ester and trimethylene carbonate linkages such that said triblock copolymer has a melting points (Tm) less than 65 degrees centigrade and a glass transition temperature (Tg) less than 20 degrees centigrade and is soluble in methylene chloride and/or chloroform.

Claim 23

A coating of claim 16 wherein the middle block is from 5 to 25 percent by weight of the copolymer.

Claim 24

A coating of claim 20 wherein the number average molecular weight of the middle block is from about 4,000 to 30,000.

Claim 25

A coating of claim 21 wherein the inherent viscosity of the copolymer, as measured at 30° C. for a 0.5% (w/v) solution in chloroform or methylene chloride, is 0.25 to about 1.50 dl/g.

Claim 26

A coating of claim 22 comprising a bioabsorbable surgical suture or ligature manufactured from a polymer prepared from one or more monomers selected from the group consisting of lactides.

Claim 27

A coating of claim 23 wherein the suture or ligature is manufactured from a homopolymer prepared from the monomer glycolide.

Claim 28

A coating of claim 24 wherein the suture or ligature is manufactured from a copolymer prepared from the monomers glycolide and lactide.

Claim 29

A coating of claim 24 wherein the suture or ligature is in multifilamentary form.

Claim 30

A coating of claim 26 comprising about 1/10 to 5% by weight of the coated suture or ligature.

Claim 31

A coating of claim 27 comprising about 1 to 3% by weight.