US5312437A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Absorbable coating composition and suture coated therewith
Assignee: United States Surgical Corp
•
Filing: 1992-06-12
•
Granted: 1994-05-17
•
Expires: 2012-06-12
Abstract
Abstract An absorbable composition for application to a surgical suture to improve the knot tie-down and/or knot security characteristics thereof is obtained from the reaction of a poly(oxypropylene) glycol and a lactide/glycolide copolymer, optionally, in the presence of an initiator and/or catalyst.
Inventors
- 👤 Matthew E. Hermes
- 👤 Donald S. Kaplan
- 👤 Nagabhushanam Totakura
- 👤 Steven L. Bennett
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:50
CPC Classifications
A; A61; A61L; A61L17/00; A61L17/14; A61L17/145; Y; Y10; Y10T; Y10T428/00; Y10T428/29; Y10T428/2913; Y10T428/2933; Y10T428/2938
Claims Analysis
Total Claims: 38
Claim 1
Independent Claim
21 words
A suture coated with a coating composition comprising the product obtained by reacting a mixture of poly(oxypropylene) glycol and lactide/glycolide copolymer.
Claim 2
Dependent Claim
21 words
A suture coated with a coating composition comprising the product obtained by reacting a mixture of poly(oxypropylene) glycol and lactide/glycolide copolymer.
Claim 3
Dependent Claim
20 words
The suture of claim 1 wherein the poly(oxypropylene) glycol possesses a molecular weight of from about 400 to about 6,000.
Claim 4
Dependent Claim
20 words
The suture of claim 1 wherein the poly(oxypropylene) glycol possesses a molecular weight of from about 1,000 to about 4,000.
Claim 5
Dependent Claim
14 words
The suture of claim 1 wherein the lactide/ glycolide copolymer is prepared with L-lactide.
Claim 6
Dependent Claim
29 words
The suture of claim 1 wherein the lactide/glycolide copolymer contains from about 90 to about 65 mole percent lactide and from about 10 to about 35 mole percent glycolide.
Claim 7
Dependent Claim
29 words
The suture of claim 1 wherein the lactide/glycolide copolymer contains from about 85 to about 70 mole percent lactide and from about 15 to about 30 mole percent glycolide.
Claim 8
Dependent Claim
55 words
The suture of claim 1 wherein the lactide/glycolide copolymer prior to reaction with the poly(oxypropylene) glycol possesses a glass transition temperature of at least about 54° C. when measured by differential scanning calorimetry at 20° C./min and an inherent viscosity of at least about 0.9 when measured in chloroform at a concentration of 0.25 g/dl.
Claim 9
Dependent Claim
29 words
The suture of claim 7 wherein the composition following reaction possesses an inherent viscosity of less than about 0.9 when measured in chloroform at a concentration of 0.25 g.dl.
Claim 10
Dependent Claim
29 words
The suture of claim 7 wherein the composition following reaction possesses an inherent viscosity of less than about 0.5 when measured in chloroform at a concentration of 0.25 g/dl.
Claim 11
Dependent Claim
22 words
The suture of claim 1 wherein the weight ratio of poly(oxypropylene) glycol to lactide/glycolide copolymer is from about 4:1 to about 1:4.
Claim 12
Dependent Claim
22 words
The suture of claim 1 wherein the weight ratio of poly(oxypropylene) glycol to lactide/glycolide copolymer is from about 2:1 to about 1:2.
Claim 13
Dependent Claim
29 words
The suture of claim 1 wherein the composition following reaction possesses in inherent viscosity of less than about 0.9 when measured in chloroform at a concentration of 0.25 g/dl.
Claim 14
Dependent Claim
29 words
The suture of claim 1 wherein the composition following reaction possesses an inherent viscosity of less than about 0.5 when measured in chloroform at a concentration of 0.25 g/dl.
Claim 15
Dependent Claim
21 words
The suture of claim 1 wherein the poly(oxypropylene) glycol is reacted with the lactide/glycolide copolymer in the presence of an initiator.
Claim 16
Dependent Claim
11 words
The suture of claim 14 wherein the initiator is a glycol.
Claim 17
Dependent Claim
11 words
The suture of claim 15 wherein the glycol is diethylene glycol.
Claim 18
Dependent Claim
13 words
The suture of claim 1 wherein the suture is a synthetic multifilament suture.
Claim 19
Dependent Claim
14 words
The suture of claim 1 wherein the suture is an absorbable synthetic multifilament suture.
Claim 20
Dependent Claim
51 words
The suture of claim 1 exhibiting improved knot tie-down and/or knot security characteristics compared with the knot tie-down and/or knot security characteristics of the same suture coated with an equivalent amount of an absorbable composition obtained by reacting a poly(oxyethylene) glycol with a mixture of lactide and glycolide and/or lactide/glycolide copolymer.
Claim 21
Independent Claim
37 words
A method of improving the knot tie-down and/or knot security characteristics of a suture which comprises coating the suture with an absorbable composition comprising the product obtained by reacting a mixture of poly(oxypropylene) glycol and lactide/glycolide copolymer.
Claim 22
Independent Claim
37 words
A method of improving the knot tie-down and/or knot security characteristics of a suture which comprises coating the suture with an absorbable composition comprising the product obtained by reacting a mixture of poly(oxypropylene) glycol and lactide/glycolide copolymer.
Claim 23
Dependent Claim
20 words
The method of claim 20 wherein the poly(oxypropylene) glycol possesses a molecular weight of from about 400 to about 6,000.
Claim 24
Dependent Claim
20 words
The method of claim 20 wherein the poly(oxypropylene) glycol possesses a molecular weight of from about 1,000 to about 4,000.
Claim 25
Dependent Claim
13 words
The method of claim 20 wherein the lactide/glycolide copolymer is prepared with L-lactide.
Claim 26
Dependent Claim
29 words
The method of claim 20 wherein the lactide/glycolide copolymer contains from about 90 to about 65 mole percent lactide and from about 10 to about 35 mole percent glycolide.
Claim 27
Dependent Claim
29 words
The method of claim 20 wherein the lactide/glycolide copolymer contains from about 85 to about 70 mole percent lactide and from about 15 to about 30 mole percent glycolide.
Claim 28
Dependent Claim
55 words
The method of claim 20 wherein the lactide/glycolide copolymer prior to reaction with the poly(oxypropylene) glycol possesses a glass transition temperature of at least about 54° C. when measured by differential scanning calorimetry at 20° C./min and an inherent viscosity of at least about 0.9 when measured in chloroform at a concentration of 0.25 g/dl.
Claim 29
Dependent Claim
29 words
The method of claim 26 wherein the composition following reaction possesses an inherent viscosity of less than about 0.9 when measured in chloroform at a concentration of 0.25 g.dl.
Claim 30
Dependent Claim
29 words
The method of claim 26 wherein the composition following reaction possesses an inherent viscosity of less than about 0.5 when measured in chloroform at a concentration of 0.25 g/dl.
Claim 31
Dependent Claim
22 words
The method of claim 20 wherein the weight ratio of poly(oxypropylene) glycol to lactide/glycolide copolymer is from about 4:1 to about 1:4.
Claim 32
Dependent Claim
22 words
The method of claim 20 wherein the weight ratio of poly(oxypropylene) glycol to lactide/glycolide copolymer is from about 2:1 to about 1:2.
Claim 33
Dependent Claim
21 words
The method of claim 20 wherein the poly(oxypropylene) glycol is reacted with the lactide/glycolide copolymer in the presence of an initiator.
Claim 34
Dependent Claim
10 words
The suture of claim 31 the initiator is a glycol.
Claim 35
Dependent Claim
11 words
The suture of claim 32 wherein the glycol is diethylene glycol.
Claim 36
Dependent Claim
13 words
The method of claim 20 wherein the suture is a synthetic multifilament suture.
Claim 37
Dependent Claim
14 words
The method of claim 20 wherein the suture is an absorbable synthetic multifilament suture.
Claim 38
Dependent Claim
56 words
The method of claim 20 wherein the resulting coated suture exhibits improved knot tie-down and/or knot security characteristics compared with the knot tie-down and/or knot security characteristics of the same suture coated with an equivalent amount of an absorbable composition obtained by reacting a poly(oxyethylene) glycol with a mixture of lactide and glycolide and/or lactide/glycolide copolymer.
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