US4744365A
Expired / Lapsed
US
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Two-phase compositions for absorbable surgical devices
Assignee: United States Surgical Corp
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Filing: 1987-09-22
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Granted: 1988-05-17
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Expires: 2007-09-22
Abstract
Abstract An absorbable, annealed surgical device made from a multi-phase, polymeric composition derived from lactide and glycolide is disclosed. Preferably, the composition has two phases, both phases are continuous, the first phase has about 0-about 25% m glycolide moieties, the overall composition has up to 45% m glycolide moieties, and the first phase constitute at least 50% (and preferably not more than about 95%) by weight of the composition. The device has a high distortion temperature, good resistance to hot-wet creep, but yet loses tensile strength in vivo quickly. The composition per se is injection-moldable, can be annealed, and is not brittle.
Inventors
- 👤 Donald S. Kaplan
- 👤 Matthew E. Hermes
- 👤 Ross R. Muth
- 👤 John J. Kennedy
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 00:50
CPC Classifications
A; A61; A61L; A61L31/00; A61L31/04; A61L31/041; A61L31/12; A61L31/125; A61L31/129
Claims Analysis
Total Claims: 32
Claim 1
Independent Claim
72 words
An absorbable, annealed surgical device of a multi-phase polymeric composition derived from lactide and glycolide, the first phase having about 0-about 25% m glycolide moieties and about 75-about 100% m lactide moieties and the other phase or phases having glycolide and lactide moieties in amounts such that the composition overall has up to 45% m glycolide moieties, wherein the first phase constitutes at least 50% by weight of the annealed surgical device.
Claim 2
Dependent Claim
72 words
An absorbable, annealed surgical device of a multi-phase polymeric composition derived from lactide and glycolide, the first phase having about 0-about 25% m glycolide moieties and about 75-about 100% m lactide moieties and the other phase or phases having glycolide and lactide moieties in amounts such that the composition overall has up to 45% m glycolide moieties, wherein the first phase constitutes at least 50% by weight of the annealed surgical device.
Claim 3
Dependent Claim
23 words
The device of claim 1 wherein the first phase has 10-20% m glycolide moieties and the composition overall has 30-45% m glycolide moieties.
Claim 4
Dependent Claim
25 words
The device of claim 1 wherein the first phase has about 10% m glycolide moieties and the composition overall has about 35% m glycolide moieties.
Claim 5
Dependent Claim
11 words
The device of claim 1 wherein the composition has two phases.
Claim 6
Dependent Claim
10 words
The device of claim 4 wherein both phases are continuous.
Claim 7
Dependent Claim
22 words
The device of claim 5 wherein the first phase has 10-20% m glycolide moieties and the composition overall has 30-45% glycolide moieties.
Claim 8
Dependent Claim
25 words
The device of claim 5 wherein the first phase has about 10% m glycolide moieties and the composition overall has about 35% m glycolide moieties.
Claim 9
Dependent Claim
18 words
The device of claim 4 wherein the first phase is continuous and the second phase comprises discrete particles.
Claim 10
Dependent Claim
15 words
The device of claim 8 wherein the discrete phase contains about 100% m glycolide moieties.
Claim 11
Dependent Claim
67 words
An annealable, injection-moldable lactide/glycolide polymeric composition having at least two phases wherein the first phase contains about 0-about 25% m glycolide moieties and about 75-about 100% m lactide moieties and the other phase or phases contain glycolide moieties in amounts such that the overall composition contains up to 45% m glycolide moieties, wherein the first phase constitutes at least 50% by weight of the annealable polymeric composition.
Claim 12
Dependent Claim
67 words
An annealable, injection-moldable lactide/glycolide polymeric composition having at least two phases wherein the first phase contains about 0-about 25% m glycolide moieties and about 75-about 100% m lactide moieties and the other phase or phases contain glycolide moieties in amounts such that the overall composition contains up to 45% m glycolide moieties, wherein the first phase constitutes at least 50% by weight of the annealable polymeric composition.
Claim 13
Dependent Claim
23 words
The composition of claim 10 wherein the first phase contains 10-20% m glycolide moieties and the composition overall has 30-45% m glycolide moieties.
Claim 14
Dependent Claim
25 words
The composition of claim 10 wherein the first phase contains about 10% m glycolide moieties and the composition overall contains about 35% m glycolide moieties.
Claim 15
Dependent Claim
10 words
The composition of claim 10 wherein there are two phases.
Claim 16
Dependent Claim
10 words
The compostion of claim 13 wherein both phases are continuous.
Claim 17
Dependent Claim
22 words
The composition of claim 14 wherein the first phase has 10-20% m glycolide moieties and the composition overall has 30-45% glycolide moieties.
Claim 18
Dependent Claim
25 words
The composition of claim 14 wherein the first phase has about 10% m glycolide moieties and the composition overall has about 35% m glycolide moieties.
Claim 19
Dependent Claim
18 words
The composition of claim 13 wherein the first phase is continuous and the second phase comprises discrete particles.
Claim 20
Dependent Claim
15 words
The composition of claim 17 wherein the discrete phase contains about 100% m glycolide moieties.
Claim 21
Dependent Claim
11 words
The device of claim 1 wherein the device is injection molded.
Claim 22
Dependent Claim
18 words
The device of claim 19 wherein the device is an injection molded staple or an injection molded clip.
Claim 23
Dependent Claim
37 words
The device of claim 4 wherein the crystallinity of the first phase is about 10-20%, based on the total device, and the crystallinity of the second phase is less than about 10%, based on the total device.
Claim 24
Dependent Claim
35 words
The composition of claim 13 wherein the crystallinity of the first phase is about 5-10%, based on the total composition, and the crystallinity of the second phase is about 1-5%, based on the total composition.
Claim 25
Dependent Claim
73 words
An absorbable, injection moldable multi-phase polymeric composition containing lactide and glycolide moieties, comprising a matrix polymer phase and a discrete polymer phase dispersed therein, the matrix phase comprising a polymer composition which is lactide-rich and the discrete phase comprising a polymer composition which is glycolide-rich and having a melting point which is higher than the melting point of the lactide-rich phase, and the multi-phase polymer composition as a whole comprising predominantly lactide moieties.
Claim 26
Dependent Claim
73 words
An absorbable, injection moldable multi-phase polymeric composition containing lactide and glycolide moieties, comprising a matrix polymer phase and a discrete polymer phase dispersed therein, the matrix phase comprising a polymer composition which is lactide-rich and the discrete phase comprising a polymer composition which is glycolide-rich and having a melting point which is higher than the melting point of the lactide-rich phase, and the multi-phase polymer composition as a whole comprising predominantly lactide moieties.
Claim 27
Dependent Claim
20 words
The composition of claim 23 wherein the polymer of both the matrix and discrete phases comprise lactide and glycolide moieties.
Claim 28
Dependent Claim
17 words
The composition of claim 23 wherein the polymer of the matrix phase comprises lactide and glycolide moieties.
Claim 29
Dependent Claim
75 words
An absorbable, annealed surgical device of multi-phase polymeric composition containing lactide and glycolide moieties, comprising a matrix polymer phase and a discrete polymer phase dispersed therein, the matrix phase comprising a polymer composition which is lactide-rich and the discrete phase comprising a polymer composition which is glycolide-rich and having a melting point which is higher than the melting point of the lactide-rich phase, and the multi-phase polymer composition as a whole comprising predominantly lactide moieties.
Claim 30
Dependent Claim
75 words
An absorbable, annealed surgical device of multi-phase polymeric composition containing lactide and glycolide moieties, comprising a matrix polymer phase and a discrete polymer phase dispersed therein, the matrix phase comprising a polymer composition which is lactide-rich and the discrete phase comprising a polymer composition which is glycolide-rich and having a melting point which is higher than the melting point of the lactide-rich phase, and the multi-phase polymer composition as a whole comprising predominantly lactide moieties.
Claim 31
Dependent Claim
20 words
The composition of claim 26 wherein the polymer of both the matrix and discrete phases comprise lactide and glycolide moieties.
Claim 32
Dependent Claim
17 words
The composition of claim 26 wherein the polymer of the matrix phase comprises lactide and glycolide moieties.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-05-17 | 1991-11-16 | 1992-05-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-05-17 | 1995-11-16 | 1996-05-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-05-17 | 1999-11-16 | 2000-05-17 | $7700.00 | Window Closed / Lapsed |