US5208355A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Cosmetic composition
Assignee: Chesebrough Ponds USA Inc
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Filing: 1991-05-01
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Granted: 1993-05-04
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Expires: 2011-05-01
Abstract
Abstract Novel amide derivatives have the following structure (1): ##STR1## where Y is hydrogen or an unsaturated fatty acid residue, A is an hydroxyalkyl group, B is a sugar or phosphate residue, and (C a H b ) is a hydrocarbon residue with from 7 to 49 carbon atoms. The amide derivative can be employed in compositions, together with a suitable carrier, for topical application, particularly to improve damaged human skin or hair.
Inventors
- 👤 Ian R. Scott
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 12:24
CPC Classifications
A; A61; A61K; A61K8/00; A61K8/02; A61K8/04; A61K8/06; C; C07; C07C; C07C233/00; C07C233/01; C07C233/45; A61K8/062; A61K8/064; A61K8/18; A61K8/30; A61K8/60; A61K8/68; A61Q; A61Q19/00; A61Q5/00; C07C235/00; C07C235/02; C07C235/04; C07C235/08; C07H; C07H15/00; C07H15/02; C07H15/04; C07H15/10; A61Q19/007
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
229 words
An amide derivative having the structure (1): ##STR12## where Y is H or a residue of an all cis n-6,9 fatty acid or a derivative thereof, having the structure (2): ##STR13## where Z is --OH or an epoxy oxygen x is an integer of from 16 to 20 y is an integer of from 24 to 36, and z is 0, or an integer of from 1 to 4; provided that: when z=0 then y is an integer from 26 to 36 or when z is an integer of from 1 to 4, then y is an integer of from 24 to 35; and where a is an integer of from 7 to 49 b is an integer of from I0 to 98 and where A is the group --(CH 2 ) c OH, where c is an integer of from 1 to 6 or ##STR14## where X 1 , X 2 , and X 3 are individually H, C 1-5 alkyl or hydroxyalkyl, and R 1 is H, a sugar residue or a phosphate residue, and where B is ##STR15## where R 2 is H, a sugar residue or phosphate residue; and R 3 is a C 8-28 aliphatic hydrocarbon or the group --CH(OH) R 3 with R 3 as defined above; and wherein at least one of R 1 and R 2 must be a phosphate residue.
Claim 2
Dependent Claim
229 words
An amide derivative having the structure (1): ##STR12## where Y is H or a residue of an all cis n-6,9 fatty acid or a derivative thereof, having the structure (2): ##STR13## where Z is --OH or an epoxy oxygen x is an integer of from 16 to 20 y is an integer of from 24 to 36, and z is 0, or an integer of from 1 to 4; provided that: when z=0 then y is an integer from 26 to 36 or when z is an integer of from 1 to 4, then y is an integer of from 24 to 35; and where a is an integer of from 7 to 49 b is an integer of from I0 to 98 and where A is the group --(CH 2 ) c OH, where c is an integer of from 1 to 6 or ##STR14## where X 1 , X 2 , and X 3 are individually H, C 1-5 alkyl or hydroxyalkyl, and R 1 is H, a sugar residue or a phosphate residue, and where B is ##STR15## where R 2 is H, a sugar residue or phosphate residue; and R 3 is a C 8-28 aliphatic hydrocarbon or the group --CH(OH) R 3 with R 3 as defined above; and wherein at least one of R 1 and R 2 must be a phosphate residue.
Claim 3
Dependent Claim
13 words
An amide derivative according to claim 1 wherein Y is a linoleoyl group.
Claim 4
Dependent Claim
13 words
An amide derivative according to claim 1 wherein Y is a linolenoyl group.
Claim 5
Dependent Claim
13 words
An amide derivative according to claim 1 wherein Y is a γ-linolenoyl group.
Claim 6
Dependent Claim
13 words
An amide derivative according to claim 1 wherein Y is a columbinoyl group.
Claim 7
Dependent Claim
13 words
An amide derivative according to claim 1 wherein Y is a arachidonoyl group.
Claim 8
Dependent Claim
75 words
A process for synthesising an amide derivative according to claim 1, which comprises the steps of: i. forming the acid chloride intermediate of a precursor having the structure (8): Y--O--(C.sub.a H.sub.b)--COOH; (8) ii. forming the silyl intermediate of an amine derivative having the structure (9): ##STR16## iii. condensing the intermediates having structures (8) and (9); and iv. deprotecting by removal of the silyl groups to form the corresponding amide derivative having the structure (1): ##STR17##
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1996-05-03 | 1996-11-02 | 1997-05-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-05-03 | 2000-11-02 | 2001-05-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-05-03 | 2004-11-02 | 2005-05-04 | $7700.00 | Window Closed / Lapsed |