US4294852A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Skin treating compositions
Assignee: Johnson and Johnson
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Filing: 1975-08-21
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Granted: 1981-10-13
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Expires: 1995-08-21
Abstract
Abstract The invention relates to a composition for treatment and control of excessively thickened, inflexible and scaly stratum corneum which often fissures into the dermis resulting in foci of bleeding and inflammation which are symptomatic of numerous altered skin conditions. More specifically, this invention relates to a composition comprising an aqueous phase comprising water in which are dissolved one or more aliphatic alcohols selected from the group consisting of n-propanol and the monohydric aliphatic alcohols having from 4 to about 8 carbon atoms, preferably n-butanol, n-pentanol and n-hexanol, in combination with one or more organic acids selected from the group consisting of the saturated aliphatic, mono, di-and tri-carboxylic acids having from 2 to about 10 carbon atoms, including those acids which are substituted at either or both of the alpha and beta carbons with a hydroxyl or keto functionality. The composition is also an excellent vehicle for topically active drugs or other skin treating agents. Optionally, the composition of the invention may include a minor amount of a lipid phase.
Inventors
- 👤 Richard H. Wildnauer
- 👤 William T. Humphries
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 21:02
CPC Classifications
A; A61; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/33; A61K8/36; A61K8/365; A61K47/00; A61K47/06; A61K47/08; A61K47/10; A61K47/12; A61K8/34; A61K8/362; A61K9/00; A61K9/0012; A61K9/0014; A61Q; A61Q19/00; A61Q19/007
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
142 words
A skin treating composition comprising (a) a major amount of an aqueous phase comprising water having dissolved therein from about 0.1 to about 35% by weight of said composition of an alcohol selected from the group consisting of n-propanol and the monohydric aliphatic alcohols having from 4 to 6 carbon atoms, and an effective amount, sufficient to adjust the pH of said composition to a pH within the range of about 2 to about 6.5, of an organic acid having from 2 to about 10 carbon atoms selected from the group consisting of the aliphatic mono-, di- and tri-carboxylic acids and the derivatives of said acids which are substituted at one or both of the alpha and beta carbons with a hydroxyl or keto group; and (b) no more than about 15% by weight of the total composition of a lipid phase.
Claim 2
Dependent Claim
142 words
A skin treating composition comprising (a) a major amount of an aqueous phase comprising water having dissolved therein from about 0.1 to about 35% by weight of said composition of an alcohol selected from the group consisting of n-propanol and the monohydric aliphatic alcohols having from 4 to 6 carbon atoms, and an effective amount, sufficient to adjust the pH of said composition to a pH within the range of about 2 to about 6.5, of an organic acid having from 2 to about 10 carbon atoms selected from the group consisting of the aliphatic mono-, di- and tri-carboxylic acids and the derivatives of said acids which are substituted at one or both of the alpha and beta carbons with a hydroxyl or keto group; and (b) no more than about 15% by weight of the total composition of a lipid phase.
Claim 3
Dependent Claim
32 words
The composition of claim 1, wherein said lipid phase comprises a saponifiable or non-saponifiable lipid selected from the group consisting of wool fat, paraffin oil, petrolatum and other pharmaceutically acceptable lipid materials.
Claim 4
Dependent Claim
19 words
The composition of claim 2, where the lipid phase does not exceed 10% by weight of the total composition.
Claim 5
Dependent Claim
19 words
The composition of claim 2, where the lipid phase does not exceed 5% by weight of the total composition.
Claim 6
Dependent Claim
16 words
The composition of claim 1, further comprising an effective amount of a topically active pharmaceutical compound.
Claim 7
Dependent Claim
45 words
The composition of claim 5, wherein said pharmaceutical compound is selected from the group consisting of retinoic acid, the anti-inflammatory corticosteroids, the topically active non-steroidal anti-inflammatory agents, antifungal agents and antimitotics, and the topically effective quaternary ammonium compounds, bisdiguanidines, carbanilides, salicylanilides, hydroxydiphenyls and organometallic antiseptics.
Claim 8
Dependent Claim
101 words
The composition of claim 5, wherein said pharmaceutical compound is selected from the group consisting of retinoic acid, urea, ascorbic acid, propylene glycol, selenium sulfide, salicylic acid, pyrrolidone 5 carboxylic acid, hydrocortisone, betamethasone benzoate, desfluorotriamcinolone, triamcinolone acetonide, dexamethasone, dexamethasone acetate, flumethasone pivalate, flumethasone valerate, deprodone propionate, bufexemac, suprofen, tetracycline, oxytetracycline, chlorotetracycline, neomycin, erythromycin, bacitracin, streptomycin, chloromycetin, griseofulvin, mycostatin, miconazole, miconazole nitrate, metholtrexate, chlorhexidine, domiphen bromide, benzalkonium chloride, cetyl pyridinium chloride, dequalinium chloride, cetyl trimethyl ammonium bromide, benzethonium chloride, methylbenzethonium chloride, 3,4,4'-trichlorocarbanilide, 3,4,5-tribromosalicylanilide, dichlorophene, tetrachlorophene, hexachlorophene, 2,4,4'-trichloro-2'-hydroxydiphenylether, zinc pyrithione, iodine and the iodophores derived from non-ionic surface active agents and from polyvinylpyrrolidone.
Claim 9
Dependent Claim
12 words
The composition of claim 5, wherein said pharmaceutical compound is retinoic acid.
Claim 10
Dependent Claim
22 words
The composition of claim 5, wherein said pharmaceutical compound is selected from the group consisting of the antibiotics and the halogen antiseptics.
Claim 11
Dependent Claim
27 words
A method for alleviating or preventing symptomatic scaling and cracking of the skin, comprising applying to the skin an effective amount of the composition of claim 1.
Claim 12
Dependent Claim
21 words
The method of claim 10, wherein said composition is applied at regular intervals from about 7 to about 21 times weekly.
Claim 13
Dependent Claim
35 words
The method of claim 11, wherein said composition contains from about 0.1% to about 5% based on the weight of the composition of an alcohol selected from the group consisting of n-butanol, n-pentanol and n-hexanol.
Claim 14
Dependent Claim
51 words
The method of claim 12, wherein said composition contains from about 0.1% to about 5% based on the weight of the composition of an acid selected from the group consisting of propionic, valeric, caproic, oxalic, malonic, succinic, adipic, pimelic, malic, lactic, alpha-hydroxy-butyric, pyruvic, betahydroxy-butyric, acetoacetic, glyceric, glycolic, citric and tartaric acids.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-10-12 | 1985-04-13 | 1985-10-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-10-12 | 1989-04-13 | 1989-10-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-10-12 | 1993-04-13 | 1993-10-13 | $7700.00 | Window Closed / Lapsed |