Patent US5501795A successfully refreshed from Google Patents.
US5501795A
Expired / Lapsed
US
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Device for depletion of the leucocyte content of blood and blood components
Assignee: Pall Corp
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Filing: 1994-07-18
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Granted: 1996-03-26
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Expires: 2014-07-18
Abstract
Abstract A high efficiency leucocyte-depletion filter for use with packed red cell concentrate derived from freshly drawn blood comprises a fibrous filter medium with a pore size of from about 0.5 to less than 3.6 μm and a CWST of from 53 to about 80. The filter is preferably used in conjunction with a gel prefilter and, optionally, a microaggregate filter so as to minimize clogging. In a preferred embodiment, the voids volume is about 60% to about 85%.
Inventors
- 👤 David B. Pall
- 👤 Thomas C. Gsell
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 07:20
CPC Classifications
B; B01; B01D; B01D39/00; B01D39/14; A; A61; A61M; A61M1/00; A61M1/36; A61M1/3621; A61M1/3627; A61M1/3633; A61M1/3679; B01D39/16; B01D39/1607; B01D39/1623; A61M2202/00; A61M2202/04; A61M2202/0413; A61M2202/0439
Claims Analysis
Total Claims: 33
Claim 1
Independent Claim
46 words
A device for the depletion of the leukocyte content of a blood product comprising a fibrous leukocyte adsorption/filtration filter having a pore diameter of from about 0.5 to about 2 μm, a negative zeta potential, and a CWST of from about 60 to about 70 dynes/cm.
Claim 2
Independent Claim
46 words
A device for the depletion of the leukocyte content of a blood product comprising a fibrous leukocyte adsorption/filtration filter having a pore diameter of from about 0.5 to about 2 μm, a negative zeta potential, and a CWST of from about 60 to about 70 dynes/cm.
Claim 3
Dependent Claim
19 words
A device according to claim 1 which further comprises a microaggregate filter upstream from the fibrous leukocyte adsorption/filtration filter.
Claim 4
Dependent Claim
66 words
A device according to claim 1 in which the fibrous leukocyte adsorption/filtration filter is disposed in a housing having an inlet and an outlet and defining a blood product flow path between the inlet and the outlet, wherein said filter is disposed within the housing across the blood product flow path, and wherein the device has a total voids volume of less than about 30 cc.
Claim 5
Dependent Claim
27 words
A device according to claim 1 in which the fibers of the fibrous leukocyte adsorption/filtration filter have been radiation grafted with a monomer containing a hydrophilic group.
Claim 6
Dependent Claim
19 words
The device of claim 1 wherein the fibrous leukocyte absorption/filtration filter is preformed to controlled density and pore diameter.
Claim 7
Dependent Claim
19 words
The device of claim 1 wherein the filter has a CWST of from about 62 to about 68 dynes/cm.
Claim 8
Dependent Claim
21 words
The device of claim 1 wherein the filter further comprises at least one of a gel prefilter and a microaggregate filter.
Claim 9
Dependent Claim
21 words
The device of claim 1 wherein the filter has a voids volume in the range of about 65% to about 84%.
Claim 10
Dependent Claim
16 words
The device of claim 1 wherein the filter has a pore diameter of about 2 μm.
Claim 11
Dependent Claim
16 words
The device of claim 1 further comprising a fibrous gel prefilter and a fibrous microaggregate filter.
Claim 12
Dependent Claim
23 words
The device of claim 10 wherein the fibrous microaggregate filter is interposed between the fibrous gel prefilter and the fibrous leukocyte adsorption/filtration filter.
Claim 13
Dependent Claim
23 words
The device of claim 1 wherein the fibrous leukocyte adsorption/filtration filter includes fibers having an average diameter of about 3 μm or less.
Claim 14
Dependent Claim
24 words
The device of claim 1 wherein the fibrous leukocyte adsorption/filtration filter has fibers that have been radiation grafted with at least one acrylic monomer;
Claim 15
Dependent Claim
24 words
The device of claim 13 wherein the fibrous leukocyte adsorption/filtration filter has fibers that have been radiation grafted with first and second acrylic monomers.
Claim 16
Dependent Claim
16 words
The device of claim 14 wherein the first acrylic monomer is methyl acrylate or methyl methacrylate.
Claim 17
Independent Claim
50 words
A device for the depletion of the leukocyte content of a blood product comprising: a fibrous microaggregate filter; and a leukocyte adsorption/filtration filter having a pore diameter of from about 0.5 to about 2 μm, a negative zeta potential, and a CWST of from about 55 to about 80 dynes/cm.
Claim 18
Independent Claim
50 words
A device for the depletion of the leukocyte content of a blood product comprising: a fibrous microaggregate filter; and a leukocyte adsorption/filtration filter having a pore diameter of from about 0.5 to about 2 μm, a negative zeta potential, and a CWST of from about 55 to about 80 dynes/cm.
Claim 19
Dependent Claim
23 words
The device of claim 16 wherein the leukocyte absorption/filtration filter is compressed to an average voids volume of about 60% to about 85%.
Claim 20
Dependent Claim
23 words
The device of claim 17 wherein the leukocyte absorption/filtration filter is compressed to an average voids volume of about 65% to about 74%.
Claim 21
Dependent Claim
25 words
A device according to claim 16 in which the leukocyte adsorption/filtration filter is hot compressed to an average voids volume of about 65% to 84%.
Claim 22
Dependent Claim
28 words
A device according to claim 16 in which the fibrous microaggregate filter comprises a fibrous web compressed to an average voids volume of about 74% to about 84%.
Claim 23
Dependent Claim
18 words
The device of claim 16 wherein the leukocyte adsorption/filtration filter has a pore diameter of about 2 μm.
Claim 24
Dependent Claim
18 words
The device of claim 16 wherein the fibrous microaggregate filter and the leukocyte adsorption/filtration filter each include multilayers.
Claim 25
Dependent Claim
15 words
The device of claim 22 wherein the leukocyte adsorption/filtration filter includes nine or more layers.
Claim 26
Dependent Claim
15 words
The device of claim 22 wherein the leukocyte adsorption/filtration filter includes two sets of multilayers.
Claim 27
Dependent Claim
21 words
The device of claim 22 wherein the fibrous microaggregate filter has a CWST of from about 55 to about 80 dynes/cm.
Claim 28
Dependent Claim
21 words
The device of claim 25 wherein the leukocyte adsorption/filtration filter has a CWST of from about 60 to about 70 dynes/cm.
Claim 29
Dependent Claim
21 words
The device of claim 26 wherein the leukocyte adsorption/filtration filter has a CWST of from about 62 to about 68 dynes/cm.
Claim 30
Dependent Claim
20 words
The device of claim 16 wherein the leukocyte adsorption/filtration filter is capable of depleting the leukocyte content of whole blood.
Claim 31
Dependent Claim
21 words
The device of claim 16 wherein the leukocyte adsorption/filtration filter is capable of depleting the leukocyte content of fresh whole blood.
Claim 32
Dependent Claim
76 words
The device of claim 16 further comprising a housing including an inlet and an outlet and defining a blood product flow path between the inlet and the outlet, said fibrous microaggregate filter and said leukocyte absorption/filtration filter disposed within the housing across the blood product flow path, wherein the fibrous microaggregate filter and the leukocyte absorption/filtration filter are arranged to deplete the leukocyte content of the blood product by a factor of at least about 30,000.
Claim 33
Dependent Claim
24 words
The device of claim 16 wherein the leukocyte adsorption/filtration filter has fibers that have been radiation grafted with a monomer containing a hydrophilic group.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-03-26 | 1999-09-25 | 2000-03-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-03-26 | 2003-09-25 | 2004-03-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-03-26 | 2007-09-25 | 2008-03-26 | $7700.00 | Window Closed / Lapsed |