US4880548A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Device and method for separating leucocytes from platelet concentrate
Assignee: Pall Corp
•
Filing: 1988-04-25
•
Granted: 1989-11-14
•
Expires: 2008-04-25
Abstract
Abstract A device for the depletion of the leucocyte content in a platelet concentrate, preferably comprising a modified porous, fibrous medium with a critical wetting surface tension of at least about 90 dynes/cm and a method for the depletion of the leucocyte content and platelet concentrate comprising passing the platelet concentrate through the porous medium.
Inventors
- 👤 David B. Pall
- 👤 Thomas C. Gsell
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 23:01
CPC Classifications
B; B01; B01D; B01D39/00; B01D39/14; B01D39/16; B01D39/1607; B01D39/1623; A; A61; A61M; A61M1/00; A61M1/36; A61M1/3621; A61M1/3627; A61M1/3633; A61M2202/00; A61M2202/04; A61M2202/0413; A61M2202/0427; A61M2202/0439
Claims Analysis
Total Claims: 99
Claim 1
Independent Claim
27 words
A device for the depletion of the leucocyte content of a platelet concentrate comprising a porous, fibrous medium having a CWST of at least about 90 dynes/cm.
Claim 2
Independent Claim
27 words
A device for the depletion of the leucocyte content of a platelet concentrate comprising a porous, fibrous medium having a CWST of at least about 90 dynes/cm.
Claim 3
Dependent Claim
18 words
The device of claim 1 in which said medium has a CWST of at least about 95 dynes/cm.
Claim 4
Dependent Claim
27 words
The device of claim 1 in which the fibers of the medium have been modified so as to present hydroxyl groups when immersed in an aqueous fluid.
Claim 5
Dependent Claim
32 words
The device of claim 3 in which the fibers have been modified by exposure to an energy source while in contact with a monomer comprising a polymerizable group and a hydroxyl-containing group.
Claim 6
Dependent Claim
16 words
The device of claim 4 in which the polymerizable group comprises an acrylic or methacrylic moeity.
Claim 7
Dependent Claim
12 words
The device of claim 4 in which the hydroxyl-containing group is hydroxyethyl.
Claim 8
Dependent Claim
12 words
The device of claim 4 in which said monomer is hydroxyethyl methacrylate.
Claim 9
Dependent Claim
29 words
The device of claim 1 in which the fibers of the medium have been modified to present hydroxyl groups together with a lesser number of a second anionic group.
Claim 10
Dependent Claim
13 words
The device of claim 8 in which the second anionic group is carboxyl.
Claim 11
Dependent Claim
28 words
The device of claim 8 in which the fibers of the medium have been modified by exposure to a monomer containing a polymerizable group and a carboxyl-containing group.
Claim 12
Dependent Claim
16 words
The device of claim 10 in which the polymerizable group comprises an acrylic or methacrylic moiety.
Claim 13
Dependent Claim
19 words
The device of claim 11 in which the polymerizable group and the carboxyl-containing group comprise the monomer, methacrylic acid.
Claim 14
Dependent Claim
26 words
The device of claim 12 in which the fibers of the medium have been modified with a mixture of monomers comprising methacrylic acid and hydroxyethyl methacrylate.
Claim 15
Dependent Claim
21 words
The device of claim 13 in which the acid/acrylate monomer weight ratio in the modifying mixture is between 0.01:1 to 0.5:1.
Claim 16
Dependent Claim
18 words
The device of claim 14 in which the concentration of hydroxyethyl methacrylate in the modifying mixture exceeds 0.1%.
Claim 17
Dependent Claim
18 words
The device of claim 15 in which the concentration of hydroxyethyl methacrylate in the modifying mixture exceeds 0.2%.
Claim 18
Dependent Claim
18 words
The device of claim 16 in which the concentration of hydroxyethyl methacrylate in the modifying mixture exceeds 0.4%.
Claim 19
Dependent Claim
27 words
The device of claim 17 in which the concentration of hydroxyethyl methacrylate in the modifying mixture is in the range of from about 0.2 to about 0.7%.
Claim 20
Dependent Claim
17 words
The device of claim 13 in which the acid monomer weight ratio is between 0.5:1 to 0.35:1.
Claim 21
Dependent Claim
25 words
The device of claim 12 in which the modification has been carried out using a grafting solution containing 2 to 10% of tertiary butyl alcohol.
Claim 22
Dependent Claim
19 words
The device of claim 20 in which the grafting solution contains about 4 to 5% of tertiary butyl alcohol.
Claim 23
Dependent Claim
35 words
The device of claim 12 in which the modification has been carried out using a grafting solution containing sufficient water soluble alcohol, or alcohol-ether to reduce its surface tension to less than about 40 dynes/cm.
Claim 24
Dependent Claim
19 words
The device of claim 22 in which the alcohol-ether is diethylene glycol monobutyl ether or ethylene glycol monobutyl ether.
Claim 25
Dependent Claim
24 words
The device of claim 1 in which at least one element of the porous medium has been preformed prior to assembly into a housing.
Claim 26
Dependent Claim
20 words
The device of claim 24 in which the preformed element comprises organic fibers less than about 30 micrometers in diameter.
Claim 27
Dependent Claim
14 words
The device of claim 1 in which the pore diameter exceeds about 3 micrometers.
Claim 28
Dependent Claim
14 words
The device of claim 1 in which the pore diameter exceeds about 3.4 micrometers.
Claim 29
Dependent Claim
14 words
The device of claim 1 in which the pore diameter exceeds about 3.8 micrometers.
Claim 30
Dependent Claim
22 words
The device of claim 1 in which the pore diameter is in the range of from about 3.8 to about 6 micrometers.
Claim 31
Dependent Claim
18 words
The device of claim 29 in which the bulk density of the medium is less than 0.36 grams/cc.
Claim 32
Dependent Claim
41 words
The device in accordance with claim 1 for use with a pooled lot of six to ten units of platelet concentrate each of about 50 to 70 ml in volume and in which the effective flow area exceeds 40 square centimeters.
Claim 33
Dependent Claim
15 words
The device of claim 31 in which the effective flow area exceeds 50 square centimeters.
Claim 34
Dependent Claim
15 words
The device of claim 32 in which the effective flow area exceeds 60 square centimeters.
Claim 35
Dependent Claim
32 words
A device in accordance with claim 1 for use with a single unit of 50 to 70 ml of platelet concentrate, in which the effective flow area exceeds about 6 square centimeters.
Claim 36
Dependent Claim
45 words
The device of claim 1 in which said medium is an element and said device further comprises a housing designed to accept the element and in which the external dimensions of the element are larger in lateral dimension than the matching housing internal lateral dimensions.
Claim 37
Dependent Claim
17 words
The device of claim 35 in which the element has the form of a right circular disc.
Claim 38
Dependent Claim
28 words
The device of claim 1 in which the porous medium has been preformed to form a preformed element of controlled pore diameter prior to assembly into a housing.
Claim 39
Dependent Claim
21 words
The device of claim 37 in which the preformed element has been shaped or sized by compression in a softened state.
Claim 40
Dependent Claim
25 words
The device of claim 1 in which a span between the upper and lower values used to define CWST is about 5 or fewer dynes/cm.
Claim 41
Dependent Claim
20 words
The device of claim 1 in which the FSA of the fibrous medium is at least 2.5 M 2 .
Claim 42
Dependent Claim
20 words
The device of claim 1 in which the FSA of the fibrous medium is greater than 3.0 M 2 .
Claim 43
Dependent Claim
20 words
The device of claim 1 in which the FSA of the fibrous medium is greater than 3.8 M 2 .
Claim 44
Dependent Claim
23 words
The device of claim 1 in which the FSA of the fibrous medium is from about 2.5 to about 4.0 M 2 .
Claim 45
Dependent Claim
23 words
The device of claim 1 in which the FSA of the fibrous medium is from about 3.3 to about 4.0 M 2 .
Claim 46
Independent Claim
40 words
A device for the depletion of the leucocyte content of a platelet concentrate comprising a porous medium having a CWST of at least about 90 dynes/cm and pore diameters in the range of from about 3.8 to about 6 micrometers.
Claim 47
Independent Claim
40 words
A device for the depletion of the leucocyte content of a platelet concentrate comprising a porous medium having a CWST of at least about 90 dynes/cm and pore diameters in the range of from about 3.8 to about 6 micrometers.
Claim 48
Independent Claim
112 words
A device for the depletion of the leucocyte content of platelet concentrate comprising a modified, porous, fibrous medium having a CWST of at least about 95 dynes/cm, a pore diameter in the range of from about 3.8 to about 6 micrometers, and a bulk density of less than 0.36 grams/cc, the fibers of said medium comprising polybutylene terephthalate and having diameters of less than 30 micrometers, the medium having an effective flow rate in excess of 40 square centimeters and the modification of the medium having been effected by the use of a mixture of methacrylic acid and hydroxyethyl methacrylate in which the acid/acrylate monomer weight ratio is between 0.05:1 to 0.35:1.
Claim 49
Independent Claim
112 words
A device for the depletion of the leucocyte content of platelet concentrate comprising a modified, porous, fibrous medium having a CWST of at least about 95 dynes/cm, a pore diameter in the range of from about 3.8 to about 6 micrometers, and a bulk density of less than 0.36 grams/cc, the fibers of said medium comprising polybutylene terephthalate and having diameters of less than 30 micrometers, the medium having an effective flow rate in excess of 40 square centimeters and the modification of the medium having been effected by the use of a mixture of methacrylic acid and hydroxyethyl methacrylate in which the acid/acrylate monomer weight ratio is between 0.05:1 to 0.35:1.
Claim 50
Dependent Claim
23 words
A method for the depletion of the leucocyte content of platelet concentrate comprising passing the platelet concentrate through the device in claim 1.
Claim 51
Dependent Claim
23 words
A method for the depletion of the leucocyte content of platelet concentrate comprising passing the platelet concentrate through the device of claim 2.
Claim 52
Dependent Claim
23 words
A method for the depletion of the leucocyte content of platelet concentrate comprising passing the platelet concentrate through the device of claim 3.
Claim 53
Dependent Claim
23 words
A method for the depletion of the leucocyte content of platelet concentrate comprising passing the platelet concentrate through the device of claim 4.
Claim 54
Dependent Claim
23 words
A method for the depletion of the leucocyte content of platelet concentrate comprising passing the platelet concentrate through the device of claim 5.
Claim 55
Dependent Claim
23 words
A method for the depletion of the leucocyte content of platelet concentrate comprising passing the platelet concentrate through the device of claim 6.
Claim 56
Dependent Claim
23 words
A method for the depletion of the leucoctye content of platelet concentrate comprising passing the platelet concentrate through the device of claim 7.
Claim 57
Dependent Claim
23 words
A method for the depletion of the leucocyte content of platelet concentrate comprising passing the platelet concentrate through the device of claim 8.
Claim 58
Dependent Claim
23 words
A method for the depletion of the leucocyte content of platelet concentrate comprising passing the platelet concentrate through the device of claim 9.
Claim 59
Dependent Claim
23 words
A method for the depletion of the leucocyte content of platelet concentrate comprising passing the platelet concentrate through the device of claim 10.
Claim 60
Dependent Claim
23 words
A method for the depletion of the leucocyte content of platelet concentrate comprising passing the platelet concentrate through the device of claim 11.
Claim 61
Dependent Claim
23 words
A method for the depletion of the leucocyte content of platelet concentrate comprising passing the platelet concentrate through the device of claim 12.
Claim 62
Dependent Claim
23 words
A method for the depletion of the leucocyte content of platelet concentrate comprising passing the platelet conentrate through the device of claim 13.
Claim 63
Dependent Claim
23 words
A method for the depletion of the leucocyte content of platelet concentrate comprising passing the platelet concentrate through the device of claim 14.
Claim 64
Dependent Claim
23 words
A method for the depletion of the leucocyte content of platelet concentrate comprising passing the platelet concentrate through the device of claim 15.
Claim 65
Dependent Claim
23 words
A method for the depletion of the leucoctye content of platelet concentrate comprising passing the platelet concentrate through the device of claim 16.
Claim 66
Dependent Claim
23 words
A method for the depletion of the leucocyte content of platelet concentrate comprising passing the platelet concentrate through the device of claim 17.
Claim 67
Dependent Claim
23 words
A method for the depletion of the leucocyte content of platelet concentrate comprising passing the platelet concentrate through the device of claim 18.
Claim 68
Dependent Claim
23 words
A method for the depletion of the leucocyte content of platelet concentrate comprising passing the platelet concentrate through the device of claim 19.
Claim 69
Dependent Claim
23 words
A method for the depletion of the leucocyte content of platelet concentrate comprising passing the platelet concentrate through the device of claim 20.
Claim 70
Dependent Claim
23 words
A method for the depletion of the leucocyte content of platelet concentrate comprising passing the platelet concentrate through the device of claim 21.
Claim 71
Dependent Claim
23 words
A method for the depletion of the leucocyte content of platelet concentrate comprising passing the platelet concentrate through the device of claim 22.
Claim 72
Dependent Claim
23 words
A method for the depletion of the leucocyte content of platelet concentrate comprising passing the platelet concentrate through the device of claim 23.
Claim 73
Dependent Claim
23 words
A method for the depletion of the leucocyte content of platelet concentrate comprising passing the platelet concentrate through the device of claim 24.
Claim 74
Dependent Claim
23 words
A method for the depletion of the leucocyte content of platelet concentrate comprising passing the platelet concentrate through the device of claim 25.
Claim 75
Dependent Claim
23 words
A method for the depletion of the leucocyte content of platelet concentrate comprising passing the platelet concentrate through the device of claim 26.
Claim 76
Dependent Claim
23 words
A method for the depletion of the leucocyte content of platelet concentrate comprising passing the platelet concentrate through the device of claim 27.
Claim 77
Dependent Claim
23 words
A method for the depletion of the leucocyte content of platelet concentrate comprising passing the platelet concentrate through the device of claim 28.
Claim 78
Dependent Claim
23 words
A method for the depletion of the leucocyte content of platelet concentrate comprising passing the platelet concentrate through the device of claim 29.
Claim 79
Dependent Claim
23 words
A method for the depletion of the leucocyte content of platelet concentrate comprising passing the platelet concentrate through the device of claim 30.
Claim 80
Dependent Claim
23 words
A method for the depletion of the leucocyte content of platelet concentrate comprising passing the platelet concentrate through the device of claim 31.
Claim 81
Dependent Claim
23 words
A method for the depletion of the leucocyte content of platelet concentrate comprising passing the platelet concentrate through the device of claim 32.
Claim 82
Dependent Claim
23 words
A method for the depletion of the leucocyte content of platelet concentrate comprising passing the platelet concentrate through the device of claim 33.
Claim 83
Dependent Claim
23 words
A method for the depletion of the leucocyte content of platelet concentrate comprising passing the platelet concentrate through the device of claim 34.
Claim 84
Dependent Claim
23 words
A method for the depletion of the leucocyte content of platelet concentrate comprising passing the platelet concentrate through the device of claim 35.
Claim 85
Dependent Claim
23 words
A method for the depletion of the leucocyte content of platelet concentrate comprising passing the platelet concentrate through the device of claim 36.
Claim 86
Dependent Claim
23 words
A method for the depletion of the leucocyte content of platelet concentrate comprising passing the platelet concentrate through the device of claim 37.
Claim 87
Dependent Claim
23 words
A method for the depletion of the leucocyte content of platelet concentrate comprising passing the platelet concentrate through the device of claim 38.
Claim 88
Dependent Claim
23 words
A method for the depletion of the leucocyte content of platelet concentrate comprising passing the platelet concentrate through the device of claim 39.
Claim 89
Dependent Claim
23 words
A method for the depletion of the leucocyte content of platelet concentrate comprising passing the platelet concentrate through the device of claim 40.
Claim 90
Dependent Claim
23 words
A method for the depletion of the leucocyte content of platelet concentrate comprising passing the platelet concentrate through the device of claim 41.
Claim 91
Dependent Claim
23 words
A method for the depletion of the leucocyte content of platelet concentrate comprising passing the platelet concentrate through the device of claim 42.
Claim 92
Dependent Claim
23 words
A method for the depletion of the leucocyte content of platelet concentrate comprising passing the platelet concentrate through the device of claim 43.
Claim 93
Dependent Claim
23 words
A method for the depletion of the leucoctye content of platelet concentrate comprising passing the platelet concentrate through the device of claim 44.
Claim 94
Dependent Claim
23 words
A method for the depletion of the leucocyte content of platelet concentrate comprising passing the platelet concentrate through the device of claim 45.
Claim 95
Dependent Claim
23 words
A method for the depletion of the leucocyte content of platelet concentrate comprising passing the platelet concentrate through the device of claim 46.
Claim 96
Independent Claim
29 words
A method for the depletion of the leucocyte content of platelet concentrate comprising passing the platelet concentrate through a porous medium having a CWST of at least 90 dynes/cm.
Claim 97
Independent Claim
29 words
A method for the depletion of the leucocyte content of platelet concentrate comprising passing the platelet concentrate through a porous medium having a CWST of at least 90 dynes/cm.
Claim 98
Independent Claim
119 words
A method for the depletion of the leucocyte content of platelet concentrate comprising passing the platelet concentrate through a device comprising a modified, porous, fibrous medium having a CWST of at least about 95 dynes/cm, a pore diameter in the range of from 3.8 to about 6 micrometers, and a bulk density of less than 0.36 grams/cc, the fibers of said medium comprsising polybutylene terephthalate and having diameters of less than 30 micrometers, the medium having an effective flow area in excess of 40 square centimeters and the modification of the medium having been effected by the use of a mixture of methacrylic acid and hydroxyethyl methacrylate in which the acid/acrylate monomer weight ratio is between 0.05:1 to 0.35:1.
Claim 99
Independent Claim
119 words
A method for the depletion of the leucocyte content of platelet concentrate comprising passing the platelet concentrate through a device comprising a modified, porous, fibrous medium having a CWST of at least about 95 dynes/cm, a pore diameter in the range of from 3.8 to about 6 micrometers, and a bulk density of less than 0.36 grams/cc, the fibers of said medium comprsising polybutylene terephthalate and having diameters of less than 30 micrometers, the medium having an effective flow area in excess of 40 square centimeters and the modification of the medium having been effected by the use of a mixture of methacrylic acid and hydroxyethyl methacrylate in which the acid/acrylate monomer weight ratio is between 0.05:1 to 0.35:1.
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1992-11-13 | 1993-05-15 | 1993-11-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-11-13 | 1997-05-15 | 1997-11-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-11-13 | 2001-05-15 | 2001-11-14 | $7700.00 | Window Closed / Lapsed |