US5229012A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method for depletion of the leucocyte content of blood and blood components
Assignee: Pall Corp
•
Filing: 1991-06-24
•
Granted: 1993-07-20
•
Expires: 2011-06-24
Abstract
Abstract A high efficiency leucocyte-depletion filter for use with packed red cell concentrate derived from freshly drawn blood comprises a fibrous filter medium with a pore size of from about 0.5 to less than 3.6 μm and a CWST of from 53 to about 80. The filter is preferably used in conjunction with a gel prefilter and, optionally, a microaggregate filter so as to minimize clogging. In a preferred embodiment, the voids volume is about 60% to about 85%.
Inventors
- 👤 David B. Pall
- 👤 Thomas C. Gsell
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 14:53
CPC Classifications
B; B01; B01D; B01D39/00; B01D39/14; A; A61; A61M; A61M1/00; A61M1/36; A61M1/3621; A61M1/3627; A61M1/3633; A61M1/3679; B01D39/16; B01D39/1607; B01D39/1623; A61M2202/00; A61M2202/04; A61M2202/0413; A61M2202/0439
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
64 words
A method for depletion of the leucocyte content of a blood product comprising passing the blood product through a fibrous leucocyte adsorption/filtration filter having a pore diameter of from about 0.5 to less than 3.6 μm and having a CWST of from 53 to about 80 dynes/cm and depleting the leucocyte content of the blood product by a factor of at least about 30,000.
Claim 2
Independent Claim
64 words
A method for depletion of the leucocyte content of a blood product comprising passing the blood product through a fibrous leucocyte adsorption/filtration filter having a pore diameter of from about 0.5 to less than 3.6 μm and having a CWST of from 53 to about 80 dynes/cm and depleting the leucocyte content of the blood product by a factor of at least about 30,000.
Claim 3
Dependent Claim
28 words
The method of claim 1 comprising passing the blood product through the leucocyte adsorption/filtration filter further having a pore diameter of from about 0.5 to about 2 μm.
Claim 4
Dependent Claim
26 words
The method of claim 1 comprising passing the blood product through the leucocyte adsorption/filtration filter further having a CWST of about 60 to about 70 dynes/cm.
Claim 5
Dependent Claim
29 words
The method of claim 1 comprising passing the blood product through the leucocyte adsorption/filtration filter having fibers which have been radiation grafted with a monomer comprising a hydrophilic group.
Claim 6
Dependent Claim
20 words
The method of claim 1 comprising passing the blood product through a microaggregate filter upstream of the leucocyte adsorption/filtration filter.
Claim 7
Dependent Claim
22 words
The method of claim 1 comprising depleting the leucocyte content of the blood product by a factor of at least about 100,000.
Claim 8
Dependent Claim
18 words
The method of claim 1 comprising passing the blood product through the leucocyte adsorption/filtration filter which is preformed.
Claim 9
Dependent Claim
20 words
The method of claim 1 comprising passing the blood product through the leucocyte adsorption/filtration filter having a negative zeta potential.
Claim 10
Dependent Claim
32 words
The method of claim 1 comprising passing the blood product through the leucocyte adsorption/filtration filter having been modified with a mixture of monomers comprising hydroxyethyl methacrylate and methyl acrylate or methyl methacrylate.
Claim 11
Dependent Claim
22 words
The method of claim 1 comprising depleting the leucocyte content of the blood product by a factor of at least about 1,000,000.
Claim 12
Dependent Claim
30 words
The method of claim 1 comprising passing the blood product through the leucocyte adsorption/filtration filter having been compressed to an average voids volume of from about 60% to about 85%.
Claim 13
Dependent Claim
31 words
The method of claim 11 comprising passing the blood product through the leucocyte adsorption/filtration filter further having been compressed to an average voids volume of from about 65% to about 84.
Claim 14
Dependent Claim
20 words
The method of claim 1 comprising passing the blood product through a gel prefilter upstream of the leucocyte adsorption/filtration filter.
Claim 15
Dependent Claim
24 words
The method of claim 13 comprising passing the blood product through a microaggregate filter interposed between the gel prefilter and the leucocyte adsorption/filtration filter.
Claim 16
Dependent Claim
22 words
The method of claim 1 comprising passing the blood product from a container holding the blood product through the leucocyte adsorption/filtration filter.
Claim 17
Dependent Claim
26 words
The method of claim 15 further comprising passing the blood product through the leucocyte adsorption/filtration filter into an additional container for holding a leucocyte-depleted blood product.
Claim 18
Independent Claim
67 words
A method for depletion of the leucocyte content of a fresh blood product comprising passing the fresh blood product through a fibrous leucocyte adsorption/filtration filter having a pore diameter of from about 0.5 to less than 3.6 μm and having a CWST of from 53 to about 80 dynes/cm and depleting the leucocyte content of the fresh blood product by a factor of at least about 30,000.
Claim 19
Independent Claim
67 words
A method for depletion of the leucocyte content of a fresh blood product comprising passing the fresh blood product through a fibrous leucocyte adsorption/filtration filter having a pore diameter of from about 0.5 to less than 3.6 μm and having a CWST of from 53 to about 80 dynes/cm and depleting the leucocyte content of the fresh blood product by a factor of at least about 30,000.
Claim 20
Dependent Claim
29 words
The method of claim 17 comprising passing the fresh blood product through the leucocyte adsorption/filtration filter further having a pore diameter of from about 0.5 to about 2 μm.
Claim 21
Dependent Claim
27 words
The method of claim 17 comprising passing the fresh blood product through the leucocyte adsorption/filtration filter further having a CWST of about 60 to about 70 dynes/cm.
Claim 22
Dependent Claim
31 words
The method of claim 17 comprising passing the fresh blood product through the leucocyte adsorption/filtration filter having been compressed to an average voids volume of from about 60% to about 85%.
Claim 23
Dependent Claim
21 words
The method of claim 17 comprising passing the fresh blood product through the leucocyte adsorption/filtration filter having a negative zeta potential.
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| 3.5 Years (Year 4) | 1996-07-19 | 1997-01-18 | 1997-07-20 | $2000.00 | Window Closed / Lapsed |
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