US4923620A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Device for depletion of the leukocyte content of blood and blood components
Assignee: Pall Corp
•
Filing: 1988-10-20
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Granted: 1990-05-08
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Expires: 2008-10-20
Abstract
Abstract Devices for the depletion of leukocytes in blood products, preferably comprising an upstream porous element including means for removal of gels, at least one intermediate porous element including means for removal of microaggregates, and a downstream element including means for removal of leukocytes by both adsorption and filtration, preferably with at least one of the elements having been modified to a CWST in excess of 53 dynes/cm.
Inventors
- 👤 David B. Pall
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 13:03
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/36; A61M1/3621; A61M1/3627; A61M1/3633; B; B01; B01D; B01D39/00; B01D39/02; B01D39/04; B01D39/14; B01D39/16; B01D39/1607; B01D39/1623; A61M2202/00; A61M2202/04; A61M2202/0413; A61M2202/0439
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
132 words
A device for separating one or more substances from a fluid to be administered to a patient, the device comprising a housing including an inlet and an outlet and defining a fluid flow path between the inlet and the outlet and a separating element disposed within the housing across the fluid flow path and including a downstream surface, wherein the inlet communicates with the housing near the bottom of the housing and upstream from the separating element and wherein the housing includes a wall facing the downstream surface of the separating element and defining a plenum and a slot disposed in the wall and communicating between the plenum and the outlet for allowing air in the fluid to separate from the fluid, said outlet being located near the top of the housing.
Claim 2
Independent Claim
132 words
A device for separating one or more substances from a fluid to be administered to a patient, the device comprising a housing including an inlet and an outlet and defining a fluid flow path between the inlet and the outlet and a separating element disposed within the housing across the fluid flow path and including a downstream surface, wherein the inlet communicates with the housing near the bottom of the housing and upstream from the separating element and wherein the housing includes a wall facing the downstream surface of the separating element and defining a plenum and a slot disposed in the wall and communicating between the plenum and the outlet for allowing air in the fluid to separate from the fluid, said outlet being located near the top of the housing.
Claim 3
Dependent Claim
13 words
The device of claim 1 wherein the slot is deeper than the plenum.
Claim 4
Dependent Claim
20 words
The device of claim 2 wherein the wall includes a plurality of concentric circular grooves which communicate with the slot.
Claim 5
Dependent Claim
18 words
The device of claim 3 wherein the slot extends from the bottom to the top of the housing.
Claim 6
Dependent Claim
30 words
The device of claim 2 wherein the slot length is 50 to 80% of an inner diameter of the housing, and the slot extends to the top of the housing.
Claim 7
Dependent Claim
16 words
The device of claim 5 wherein the slot depth increases towards the top of the housing.
Claim 8
Dependent Claim
39 words
The device of claim 2 wherein the housing has a generally circular configuration and the slot extends from the top of the housing along at least a portion of the length of the vertical inner diameter of the housing.
Claim 9
Dependent Claim
18 words
The device of claim 1 wherein the slot extends from the bottom to the top of the housing.
Claim 10
Dependent Claim
23 words
A method for the depletion of the leukocyte content of blood product comprising passing the blood product through the device of claim 1.
Claim 11
Independent Claim
204 words
A device for separating one or more substances from a fluid to be administered to a patient, the device comprising a generally cylindrical housing including an inlet and an outlet and defining a fluid flow path between the inlet and the outlet and a disc shaped separation element disposed within the housing and having upstream and downstream surfaces, wherein the housing further includes an inlet section facing the upstream surface of the separating element and defining an inlet plenum, the inlet including a ridge extending vertically along the exterior of the inlet section and a first passageway which opens at the top of the inlet ridge, extends through the inlet ridge, and communicates with the inlet plenum at the bottom of the housing, and an outlet section facing the downstream surface of the separating element and defining an outlet plenum and including a slot which is deeper than the outlet plenum and which communicates between the outlet plenum and the outlet, the outlet including a ridge extending vertically along the exterior of the outlet section and a second passageway which opens at the bottom of the outlet ridge, extends through the outlet ridge, and communicates with the slot near the top of the housing.
Claim 12
Independent Claim
204 words
A device for separating one or more substances from a fluid to be administered to a patient, the device comprising a generally cylindrical housing including an inlet and an outlet and defining a fluid flow path between the inlet and the outlet and a disc shaped separation element disposed within the housing and having upstream and downstream surfaces, wherein the housing further includes an inlet section facing the upstream surface of the separating element and defining an inlet plenum, the inlet including a ridge extending vertically along the exterior of the inlet section and a first passageway which opens at the top of the inlet ridge, extends through the inlet ridge, and communicates with the inlet plenum at the bottom of the housing, and an outlet section facing the downstream surface of the separating element and defining an outlet plenum and including a slot which is deeper than the outlet plenum and which communicates between the outlet plenum and the outlet, the outlet including a ridge extending vertically along the exterior of the outlet section and a second passageway which opens at the bottom of the outlet ridge, extends through the outlet ridge, and communicates with the slot near the top of the housing.
Claim 13
Dependent Claim
59 words
The device of claim 10 wherein the inlet section includes a plurality of concentric circular grooves and an access extending between the inlet passageway and each circular groove, the circular grooves and the access collectively defining the inlet plenum and the inlet plenum having a depth which is greatest at the bottom of the housing near the inlet passageway.
Claim 14
Dependent Claim
54 words
The device of claim 10 wherein the outlet section includes a plurality of concentric circular grooves which communicate with the slot and wherein the slot extends from near the bottom of the housing to the top of the housing and has a greater depth at the top of the housing than at the bottom.
Claim 15
Dependent Claim
40 words
The device of claim 10 wherein the housing further includes a cylindrical collar disposed about the periphery of the disc shaped separation element, the disc shaped separation element being sealed to the cylindrical collar by an interference fit between them.
Claim 16
Dependent Claim
23 words
A method for the depletion of the leukocyte content of blood product comprising passing the blood product through the device of claim 10.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-05-07 | 1993-11-06 | 1994-05-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-05-07 | 1997-11-06 | 1998-05-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-05-07 | 2001-11-06 | 2002-05-08 | $7700.00 | Window Closed / Lapsed |