US5344561A
Expired / Lapsed
US
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Device for depletion of the leucocyte content of blood and blood components
Assignee: Pall Corp
•
Filing: 1993-06-07
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Granted: 1994-09-06
•
Expires: 2013-06-07
Abstract
Abstract A high efficiency leucocyte-depletion filter for use with packed red cell concentrate derived from freshly drawn blood comprises a fibrous filter medium with a pore size of from about 0.5 to less than 3.6 μm and a CWST of from 53 to about 80. The filter is preferably used in conjunction with a gel prefilter and, optionally, a microaggregate filter so as to minimize clogging. In a preferred embodiment, the voids volume is about 60% to about 85%.
Inventors
- 👤 David B. Pall
- 👤 Thomas C. Gsell
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 03:58
CPC Classifications
B; B01; B01D; B01D39/00; B01D39/14; A; A61; A61M; A61M1/00; A61M1/36; A61M1/3621; A61M1/3627; A61M1/3633; A61M1/3679; B01D39/16; B01D39/1607; B01D39/1623; A61M2202/00; A61M2202/04; A61M2202/0413; A61M2202/0439
Claims Analysis
Total Claims: 29
Claim 1
Independent Claim
49 words
A device for the depletion of the leukocyte content of a blood product comprising a fibrous leukocyte adsorption/filtration filter having a negative zeta potential and a pore diameter of from about 0.5 to less than about 2 μm and having a CWST of from 53 to about 80 dynes/cm.
Claim 2
Independent Claim
49 words
A device for the depletion of the leukocyte content of a blood product comprising a fibrous leukocyte adsorption/filtration filter having a negative zeta potential and a pore diameter of from about 0.5 to less than about 2 μm and having a CWST of from 53 to about 80 dynes/cm.
Claim 3
Dependent Claim
18 words
The device of claim 1 further comprising at least one of a gel prefilter and a microaggregate filter.
Claim 4
Dependent Claim
14 words
The device of claim 1 further comprising a gel prefilter and a microaggregate filter.
Claim 5
Dependent Claim
68 words
The device of claim 1 further comprising a housing including an inlet and an outlet and defining a blood product flow path between the inlet and the outlet, said fibrous leukocyte absorption/filtration filter disposed within the housing across the blood product flow path, wherein the fibrous leukocyte absorption/filtration filter is arranged to deplete the leukocyte content of the blood product by a factor of at least about 30,000.
Claim 6
Dependent Claim
81 words
The device of claim 1 further comprising a microaggregate filter element and a housing including an inlet and an outlet and defining a blood product flow path between the inlet and the outlet, said microaggregate filter and said fibrous leukocyte absorption/filtration filter disposed within the housing across the blood product flow path, wherein the microaggregate filter and the fibrous leukocyte absorption/filtration filter are arranged to deplete the leukocyte content of the blood product by a factor of at least about 30,000.
Claim 7
Dependent Claim
83 words
The device of claim 3 further comprising a housing including an inlet and an outlet and defining a blood product flow path between the inlet and the outlet, said gel prefilter, said microaggregate filter, and said fibrous leukocyte absorption/filtration filter disposed within the housing across the blood product flow path, wherein the gel prefilter, the microaggregate filter, and the fibrous leukocyte absorption/filtration filter are arranged to deplete the leukocyte content of the blood product by an average log reduction of about log 6.
Claim 8
Dependent Claim
19 words
The device of claim 1 wherein the fibrous leukocyte absorption/filtration filter is preformed to controlled density and pore diameter.
Claim 9
Dependent Claim
61 words
The device of claim 1 further comprising a housing including an inlet and an outlet and defining a blood product flow path between the inlet and the outlet, said fibrous leukocyte absorption/filtration filter disposed within the housing across the blood product flow path, wherein the fibrous leukocyte absorption/filtration filter is arranged to deplete the leukocyte content of a fresh blood product.
Claim 10
Dependent Claim
59 words
The device of claim 1 further comprising a housing including an inlet and an outlet and defining a blood product flow path between the inlet and the outlet, said fibrous leukocyte absorption/filtration filter disposed within the housing across the blood product flow path, wherein the fibrous leukocyte absorption/filtration filter is arranged to deplete the leukocyte content of whole blood.
Claim 11
Dependent Claim
21 words
The device of claim 1 wherein the fibrous leukocyte absorption/filtration filter has a CWST of about 60 to about 70 dynes/cm.
Claim 12
Dependent Claim
24 words
The device of claim 1 wherein the fibrous leukocyte absorption/filtration filter is compressed to an average voids volume of about 60% to about 85%.
Claim 13
Dependent Claim
24 words
The device of claim 11 wherein the fibrous leukocyte absorption/filtration filter is compressed to an average voids volume of about 65% to about 74%.
Claim 14
Dependent Claim
22 words
The device of claim 1 wherein the fibrous leukocyte absorption/filtration filter includes fibers having an average diameter of less than 3 μm.
Claim 15
Dependent Claim
14 words
The device of claim 1 wherein the fibrous leukocyte absorption/filtration filter includes synthetic fibers.
Claim 16
Dependent Claim
24 words
The device of claim 1 wherein the leucocyte adsorption/filtration filter includes fibers which have been radiation grafted with a monomer comprising a hydrophilic group.
Claim 17
Dependent Claim
27 words
The device of claim 1 wherein the leucocyte adsorption/filtration filter includes fibers modified with a mixture of monomers comprising hydroxyethyl methacrylate and methyl acrylate or methyl methacrylate.
Claim 18
Dependent Claim
13 words
The device of claim 1 wherein the leucocyte adsorption/filtration filter includes multiple layers.
Claim 19
Independent Claim
56 words
A device for the depletion of the leukocyte content of a fresh blood product comprising a fibrous leukocyte adsorption/filtration filter having a negative zeta potential, a pore diameter of from about 0.5 to about 2 μm, a voids volume of about 65% to about 84% and having a CWST of from 53 to about 80 dynes/cm.
Claim 20
Independent Claim
56 words
A device for the depletion of the leukocyte content of a fresh blood product comprising a fibrous leukocyte adsorption/filtration filter having a negative zeta potential, a pore diameter of from about 0.5 to about 2 μm, a voids volume of about 65% to about 84% and having a CWST of from 53 to about 80 dynes/cm.
Claim 21
Independent Claim
47 words
A device for the depletion of the leukocyte content of a fresh blood product comprising a fibrous leukocyte adsorption/filtration filter having a negative zeta potential, a pore diameter of from about 0.5 to about 2 μm, and a CWST of from about 62 to about 68 dynes/cm.
Claim 22
Independent Claim
47 words
A device for the depletion of the leukocyte content of a fresh blood product comprising a fibrous leukocyte adsorption/filtration filter having a negative zeta potential, a pore diameter of from about 0.5 to about 2 μm, and a CWST of from about 62 to about 68 dynes/cm.
Claim 23
Independent Claim
62 words
A device for the depletion of the leukocyte content of a blood product comprising a fibrous leukocyte adsorption/filtration filter including multilayers, said filter having a negative zeta potential, a pore diameter of from about 0.5 to about 2 μm, a CWST of from about 62 to about 68 dynes/cm, and including synthetic fibers having an average diameter of less than 3 μm.
Claim 24
Independent Claim
62 words
A device for the depletion of the leukocyte content of a blood product comprising a fibrous leukocyte adsorption/filtration filter including multilayers, said filter having a negative zeta potential, a pore diameter of from about 0.5 to about 2 μm, a CWST of from about 62 to about 68 dynes/cm, and including synthetic fibers having an average diameter of less than 3 μm.
Claim 25
Dependent Claim
16 words
The device of claim 20 wherein the fibrous leukocyte adsorption/filtration filter includes nine or more layers.
Claim 26
Dependent Claim
16 words
The device of claim 20 wherein the fibrous leukocyte adsorption/filtration filter includes two sets of multilayers.
Claim 27
Independent Claim
107 words
A system for the depletion of the leukocyte content of a blood product comprising a device including a housing having an inlet and an outlet and defining a blood product flow path between the inlet and the outlet, and a fibrous leukocyte absorption/filtration filter disposed within the housing across the blood product flow path, the filter having a negative zeta potential and a pore diameter of from about 0.5 to less than about 2 μm and having a CWST of from about 55 to about 80 dynes/cm; at least one container in fluid communication with the device; and, a conduit interposed between the container and the device.
Claim 28
Independent Claim
107 words
A system for the depletion of the leukocyte content of a blood product comprising a device including a housing having an inlet and an outlet and defining a blood product flow path between the inlet and the outlet, and a fibrous leukocyte absorption/filtration filter disposed within the housing across the blood product flow path, the filter having a negative zeta potential and a pore diameter of from about 0.5 to less than about 2 μm and having a CWST of from about 55 to about 80 dynes/cm; at least one container in fluid communication with the device; and, a conduit interposed between the container and the device.
Claim 29
Dependent Claim
29 words
The system of claim 23 further comprising at least an additional container in fluid communication with the device, and a conduit interposed between the additional container and the device.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-09-05 | 1998-03-07 | 1998-09-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-09-05 | 2002-03-07 | 2002-09-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-09-05 | 2006-03-07 | 2006-09-06 | $7700.00 | Window Closed / Lapsed |