US5217627A
Expired / Lapsed
US
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System and method for processing biological fluid
Assignee: Pall Corp
•
Filing: 1991-11-06
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Granted: 1993-06-08
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Expires: 2011-11-06
Abstract
Abstract A system for collecting and processing donated blood comprises a first porous medium interposed between a blood collection bag and a satellite bag and a second porous medium interposed between the blood collection bag and another satellite bag. The porous media are leucocyte depletion media. The system may also include one or more of the following: a red cell barrier medium, a separation medium, a gas inlet, and a gas outlet. The system can be used to centrifuge whole blood into one or more components, and includes a means for protecting the system during centrifugation.
Inventors
- 👤 David B. Pall
- 👤 Thomas C. Gsell
- 👤 Vlado I. Matkovich
- 👤 Thomas Bormann
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 19:11
CPC Classifications
B; B01; B01D; B01D63/00; B01D63/08; B01D63/087; A; A61; A61J; A61J1/00; A61J1/05; A61M; A61M1/00; A61M1/02; A61M1/0209; A61M1/0218; A61M1/0227; A61M1/0231; A61M1/025; A61M1/029; A61M1/34; A61M1/3472; A61M1/36; A61M1/3621; A61M1/3627; A61M1/3633; A61M1/3643; A61M1/3644; A61M1/3646; A61M1/3652; B01D61/00; B01D61/14; B01D61/145; B01D61/147; B01D61/16; B01D61/20; B01D61/22; B01D65/00; B01D65/08; A61J1/10; A61M1/3693; A61M2202/00; A61M2202/04; A61M2202/0413; A61M2202/0415; A61M2202/0427; A61M2202/0429; A61M2202/0439; A61M2206/00; A61M2206/10; A61M2206/12; A61M5/00; A61M5/14; A61M5/142; A61M5/145; A61M5/148; A61M5/1483; A61M5/1486; B01D2321/00; B01D2321/20; B01D2321/2083
Claims Analysis
Total Claims: 43
Claim 1
Independent Claim
41 words
A method for processing a biological fluid comprising: expressing a biological fluid from a first container to a first porous medium comprising a red cell barrier medium; and expressing a biological fluid from the first container to a second porous medium.
Claim 2
Independent Claim
41 words
A method for processing a biological fluid comprising: expressing a biological fluid from a first container to a first porous medium comprising a red cell barrier medium; and expressing a biological fluid from the first container to a second porous medium.
Claim 3
Dependent Claim
50 words
The method of claim 1 further comprising expressing the biological fluid in the first container to the first porous medium until the red cell barrier medium is blocked, and expressing the biological fluid in the first container to the second porous medium after the red cell barrier medium is blocked.
Claim 4
Dependent Claim
35 words
The method of claim 1 further comprising expressing the biological fluid from the first container to the first porous medium and expressing the biological fluid from the first container to a second porous medium concurrently.
Claim 5
Dependent Claim
35 words
The method of claim 1 further comprising expressing the biological fluid from the first container to the first porous medium and expressing the biological fluid from the first container to a second porous medium sequentially.
Claim 6
Dependent Claim
24 words
The method of claim 1 further comprising passing the biological fluid through a red cell barrier medium and then through a leucocyte depletion medium.
Claim 7
Dependent Claim
20 words
The method of claim 1 further comprising introducing gas through a gas inlet and expelling gas through a gas outlet.
Claim 8
Dependent Claim
17 words
The method of claim 1 further comprising processing the biological fluid within about 8 hours of collection.
Claim 9
Dependent Claim
16 words
The method of claim 1 further comprising processing the biological fluid in a closed sterile system.
Claim 10
Dependent Claim
51 words
The method of claim 1 wherein expressing the biological fluid from the first container to the first porous medium comprises expressing a supernatant layer of the biological fluid; and expressing the biological fluid from the first container to the second porous medium comprises expressing a sediment layer of the biological fluid.
Claim 11
Dependent Claim
50 words
The method of claim 9 further comprising expressing the supernatant layer of the biological fluid to the first porous medium until the red cell barrier medium is blocked, and expressing the sediment layer of the biological fluid to the second porous medium after the red cell barrier medium is blocked.
Claim 12
Independent Claim
48 words
A method for processing whole blood comprising: centrifuging whole blood; expressing a supernatant layer of the centrifuged blood through a first porous medium comprising a red cell barrier medium; and expressing a sediment layer of the centrifuged blood through a second porous medium comprising a leucocyte depletion medium.
Claim 13
Independent Claim
48 words
A method for processing whole blood comprising: centrifuging whole blood; expressing a supernatant layer of the centrifuged blood through a first porous medium comprising a red cell barrier medium; and expressing a sediment layer of the centrifuged blood through a second porous medium comprising a leucocyte depletion medium.
Claim 14
Dependent Claim
50 words
The method of claim 11 further comprising expressing the supernatant layer of the centrifuged blood through the first porous medium until the red cell barrier medium is blocked, and expressing the sediment layer of the centrifuged blood through the second porous medium after the red cell barrier medium is blocked.
Claim 15
Dependent Claim
35 words
The method of claim 11 further comprising expressing the supernatant layer of the centrifuged blood through the first porous medium and expressing the sediment layer of the centrifuged blood through the second porous medium concurrently.
Claim 16
Dependent Claim
35 words
The method of claim 11 further comprising expressing the supernatant layer of the centrifuged blood through the first porous medium and expressing the sediment layer of the centrifuged blood through the second porous medium simultaneously.
Claim 17
Dependent Claim
22 words
The method of claim 11 further comprising passing the supernatant layer through a leucocyte depletion medium downstream of the first porous medium.
Claim 18
Dependent Claim
21 words
The method of claim 15 further comprising passing the supernatant layer through a separation medium downstream of the leucocyte depletion medium.
Claim 19
Independent Claim
53 words
A method for processing whole blood comprising: centrifuging whole blood; expressing a supernatant layer of the centrifuged blood through a first porous medium comprising a red cell barrier medium and a leucocyte depletion medium; and expressing a sediment layer of the centrifuged blood through a second porous medium comprising a leucocyte depletion medium.
Claim 20
Independent Claim
53 words
A method for processing whole blood comprising: centrifuging whole blood; expressing a supernatant layer of the centrifuged blood through a first porous medium comprising a red cell barrier medium and a leucocyte depletion medium; and expressing a sediment layer of the centrifuged blood through a second porous medium comprising a leucocyte depletion medium.
Claim 21
Independent Claim
47 words
A method for processing whole blood comprising: centrifuging whole blood; expressing a supernatant layer of the centrifuged blood through a first porous medium comprising a red cell barrier medium until the red cell barrier medium is blocked; and then, passing the supernatant layer through a separation medium.
Claim 22
Independent Claim
47 words
A method for processing whole blood comprising: centrifuging whole blood; expressing a supernatant layer of the centrifuged blood through a first porous medium comprising a red cell barrier medium until the red cell barrier medium is blocked; and then, passing the supernatant layer through a separation medium.
Claim 23
Dependent Claim
24 words
The method of claim 21 wherein passing the supernatant layer through a separation medium comprises separating the supernatant layer into one or more components.
Claim 24
Dependent Claim
22 words
The method of claim 22 further comprising collecting the one or more components of the supernatant layer in at least one container.
Claim 25
Dependent Claim
51 words
A biological fluid processing system comprising: a first container; a first porous medium comprising a red cell barrier medium communicating with the first container, and defining a first flow path; and a second porous medium comprising a leucocyte depletion medium communicating with the first container, and defining a second flow path.
Claim 26
Dependent Claim
51 words
A biological fluid processing system comprising: a first container; a first porous medium comprising a red cell barrier medium communicating with the first container, and defining a first flow path; and a second porous medium comprising a leucocyte depletion medium communicating with the first container, and defining a second flow path.
Claim 27
Dependent Claim
19 words
The biological fluid processing system of claim 21 further comprising a second container communicating with the second porous medium.
Claim 28
Dependent Claim
20 words
The biological fluid processing system of claim 21 further comprising a leucocyte depletion medium downstream of the first porous medium.
Claim 29
Dependent Claim
21 words
The biological fluid processing system of claim 21 further comprising at least one gas inlet and at least one gas outlet.
Claim 30
Dependent Claim
16 words
The biological fluid processing system of claim 14 wherein the system comprises a closed sterile system.
Claim 31
Dependent Claim
47 words
A biological fluid processing system comprising: a first container; a first porous medium comprising a red cell barrier medium communicating with the first container and defining a first flow path; a second container downstream of, and communicating with, the first container and defining a second flow path.
Claim 32
Dependent Claim
47 words
A biological fluid processing system comprising: a first container; a first porous medium comprising a red cell barrier medium communicating with the first container and defining a first flow path; a second container downstream of, and communicating with, the first container and defining a second flow path.
Claim 33
Dependent Claim
45 words
A biological fluid processing system comprising: a first container; a first porous medium comprising a red cell barrier medium communicating with the first container; and a second porous medium comprising a leucocyte depletion medium communicating with the first container independently of the first porous medium.
Claim 34
Dependent Claim
45 words
A biological fluid processing system comprising: a first container; a first porous medium comprising a red cell barrier medium communicating with the first container; and a second porous medium comprising a leucocyte depletion medium communicating with the first container independently of the first porous medium.
Claim 35
Dependent Claim
23 words
The system of claim 27, wherein the first porous medium and the second porous medium independently communicate with the first container by conduits.
Claim 36
Dependent Claim
59 words
A biological fluid processing system comprising: a first container; a first porous medium comprising a porous red cell barrier medium having a CWST of greater than about 70 dynes/cm communicating with the first container; and a second porous medium comprising a porous leucocyte depletion medium having a CWST of greater than about 53 dynes/cm communicating with the first container.
Claim 37
Dependent Claim
59 words
A biological fluid processing system comprising: a first container; a first porous medium comprising a porous red cell barrier medium having a CWST of greater than about 70 dynes/cm communicating with the first container; and a second porous medium comprising a porous leucocyte depletion medium having a CWST of greater than about 53 dynes/cm communicating with the first container.
Claim 38
Dependent Claim
56 words
A biological fluid processing system comprising: a first container; a first porous medium comprising a red cell barrier medium and a leucocyte depletion medium communicating with the first container, and defining a first flow path; and a second porous medium comprising a leucocyte depletion medium communicating with the first container, and defining a second flow path.
Claim 39
Dependent Claim
56 words
A biological fluid processing system comprising: a first container; a first porous medium comprising a red cell barrier medium and a leucocyte depletion medium communicating with the first container, and defining a first flow path; and a second porous medium comprising a leucocyte depletion medium communicating with the first container, and defining a second flow path.
Claim 40
Dependent Claim
37 words
A biological fluid processing system comprising: a first container; a first porous medium comprising a red cell barrier medium communicating with the first container; and a separation medium downstream of, and communicating with, the first porous medium.
Claim 41
Dependent Claim
37 words
A biological fluid processing system comprising: a first container; a first porous medium comprising a red cell barrier medium communicating with the first container; and a separation medium downstream of, and communicating with, the first porous medium.
Claim 42
Dependent Claim
71 words
A biological fluid processing system comprising: a first container; a first porous medium comprising a red cell barrier medium communicating with the first container; a second porous medium comprising a leucocyte depletion medium communicating with the first container independently of the first porous medium; a third container communicating with the second porous medium; a second container communicating with the first porous medium; and, a fourth container communicating with the second container.
Claim 43
Dependent Claim
71 words
A biological fluid processing system comprising: a first container; a first porous medium comprising a red cell barrier medium communicating with the first container; a second porous medium comprising a leucocyte depletion medium communicating with the first container independently of the first porous medium; a third container communicating with the second porous medium; a second container communicating with the first porous medium; and, a fourth container communicating with the second container.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-06-07 | 1996-12-07 | 1997-06-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-06-07 | 2000-12-07 | 2001-06-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-06-07 | 2004-12-07 | 2005-06-08 | $7700.00 | Window Closed / Lapsed |