Liquid polymer composition, and method of use

Claim 2

A sustained-released liquid polymer composition which consists essentially of: (a) one or more sustained release acrylic polymers; (b) a pharmacological agent; (c) a release adjusting agent selected from the group consisting of a cross-linking agent, a polysaccharide, a lipid, a protein, a sodium citrate, sodium docusate, an amino acid and sodium polyphosphate; and (d) a pharmaceutically acceptable vehicle selected from the group consisting of water; ethyl alcohol; and ethyl alcohol and water, wherein said sustained release acrylic polymers are selected from the group consisting of: (1) a methacrylic acid type A copolymer, an anionic copolymer based on methacrylic acid and methylmethacrylate wherein the ratio of free carboxyl groups to the ester groups is approximately 1:1; (2) a methacrylic acid type B compolymer, an anionic copolymer based on methacrylic acid and methylmethacrylate wherein the ratio of free carboxyl groups to the ester groups is approximately 1:2, (3) a dimethylaminoethylacrylate/ethylmethacrylate copolymer, a copolymer based on acrylic and methacrylic acid esters with a low content of quaternary ammonium groups wherein the molar ratio of the ammonium groups to the remaining neutral (meth)acrylic acid esters is 1:20; and (4) an ethyl methacrylate/chlorotrimethylammoniumethyl methacrylate copolymer, a copolymer based on acrylic and methacrylic acid esters with a low content of quaternary ammonium groups wherein the molar ratio of the ammonium groups to the remaining neutral (meth)acrylic acid esters is 1:40.

Claim 3

The liquid polymer composition of claim 1, wherein said amino acid is selected from the group consisting of: arginine, lysine, aspartic acid, and glutaric acid.

Claim 4

The liquid polymer composition of claim 1, wherein said pharmacological agent is selected from the group consisting of: an antibiotic, an antiseptic, an anti-fungal agent, an anti-viral agent, and a hypersensitivity agent.

Claim 5

The liquid polymer composition of claim 1, wherein said pharmacological agent is a bacteriocidal quaternary ammonium salt.

Claim 6

The liquid polymer composition of claim 4 wherein said bacteriocidal quaternary ammonium salt is selected from the group consisting of cetylpyridinium chloride and benzalkonium chloride.

Claim 7

The liquid polymer composition of claim 5, wherein said bacteriocidal quaternary ammonium salt is cetylpyridinium chloride.

Claim 8

The liquid polymer composition of claim 5, wherein said bacteriocidal quaternary ammonium salt is benzalkonium chloride.

Claim 9

The liquid polymer composition of claim 3, wherein said pharmacological agent is a hypersensitivity agent.

Claim 10

The liquid polymer composition of claim 8, wherein said hypersensitivity agent is selected from the group consisting of a strontium salt, a potassium salt, a fluoride and an oxylate.

Claim 11

The liquid polymer composition of claim 9, wherein said strontium salt is selected from the group consisting of strontium chloride and strontium citrate.

Claim 12

The liquid polymer composition of claim 9, wherein said potassium salt is selected from the group consisting of potassium chloride, potassium hydrogen tartrate and potassium nitrate.

Claim 13

The liquid polymer composition of claim 9, wherein said fluoride is stannous fluoride.

Claim 14

The liquid polymer composition of claim 9, wherein said oxylate is potassium hydrogen oxylate.

Claim 15

A sustained-released liquid polymer composition which consists essentially of: (a) one or more sustained release acrylic polymers; (b) a pharmacological agent; (c) a release adjusting agent selected from the group consisting of a cross-linking agent, a polysaccharide, a lipid, a protein, a sodium citrate, sodium docusate, an amino acid and sodium polyphosphate; (d) a pharmaceutically acceptable vehicle selected from the group consisting of water; ethyl alcohol; and ethyl alcohol and water; and (e) a plasticizer; wherein said sustained release acrylic polymers are selected from the group consisting of: (1) a methacrylic acid type A copolymer, an anionic copolymer based on methacrylic acid and methylmethacrylate wherein the ratio of free carboxyl groups to the ester groups is approximately 1:1; (2) a methacrylic acid type B copolymer, an anionic copolymer based on methacrylic acid and methylmethacrylate wherein the ratio of free carboxyl groups to the ester groups is approximately 1:2; (3) a dimethylaminoethylacrylate/ethylmethacrylatecopolymer, a copolymer based on acrylic and methacrylic acid esters with a low content of quaternary ammonium groups wherein the molar ratio of the ammonium groups to the remaining neutral (meth)acrylic acid esters is 1:20; and (4) an ethyl methacrylate/chlorotrimethylammoniumethyl methacrylate copolymer, a copolymer based on acrylic and methacrylic acid esters with a low content of quaternary ammonium groups wherein the molar ratio of the ammonium groups to the remaining neutral (meth)acrylic acid esters is 1:40.

Claim 16

A sustained-released liquid polymer composition which consists essentially of: (a) one or more sustained release acrylic polymers; (b) a pharmacological agent; (c) a release adjusting agent selected from the group consisting of a cross-linking agent, a polysaccharide, a lipid, a protein, a sodium citrate, sodium docusate, an amino acid and sodium polyphosphate; (d) a pharmaceutically acceptable vehicle selected from the group consisting of water; ethyl alcohol; and ethyl alcohol and water; and (e) a plasticizer; wherein said sustained release acrylic polymers are selected from the group consisting of: (1) a methacrylic acid type A copolymer, an anionic copolymer based on methacrylic acid and methylmethacrylate wherein the ratio of free carboxyl groups to the ester groups is approximately 1:1; (2) a methacrylic acid type B copolymer, an anionic copolymer based on methacrylic acid and methylmethacrylate wherein the ratio of free carboxyl groups to the ester groups is approximately 1:2; (3) a dimethylaminoethylacrylate/ethylmethacrylatecopolymer, a copolymer based on acrylic and methacrylic acid esters with a low content of quaternary ammonium groups wherein the molar ratio of the ammonium groups to the remaining neutral (meth)acrylic acid esters is 1:20; and (4) an ethyl methacrylate/chlorotrimethylammoniumethyl methacrylate copolymer, a copolymer based on acrylic and methacrylic acid esters with a low content of quaternary ammonium groups wherein the molar ratio of the ammonium groups to the remaining neutral (meth)acrylic acid esters is 1:40.

Claim 17

The liquid polymer composition of claim 14, wherein said plasticizer is selected from the group consisting of: polyethylene glycol and dibutyl phthalate.

Claim 18

The liquid polymer composition of claim 1, wherein said cross-linking agent is selected from the group consisting of glutaraldehyde, citric acid, lysine, aspartic acid, and glutaric acid.

Claim 19

The liquid polymer composition of claim 1, wherein said polysaccharide is dextran.

Claim 20

The liquid polymer composition of claim 1, wherein said lipid is sodium docusate.