Patent US2599586A successfully refreshed from Google Patents.
US4876092A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Sheet-shaped adhesive preparation applicable to oral cavity
Assignee: Teikoku Seiyaku Co Ltd
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Filing: 1987-01-30
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Granted: 1989-10-24
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Expires: 2007-01-30
Abstract
Abstract A sheet-shaped adhesive preparation comprising an adhesive layer containing as essential components a carboxyvinyl polymer, a water-insoluble methacrylic copolymer, a polyhydric alcohol and a pharmaceutically active agent, and a water-impermeable and water-insoluble carrier layer containing as essential components a pharmaceutically acceptable water-insoluble, film-forming high molecular weight compound and a plasticizer, which can adhere within the oral cavity for a longer period of time and can release the active agent and hence is useful as a sustained release preparation for the oral cavity.
Inventors
- 👤 Tadafumi Mizobuchi
- 👤 Akihito Ohji
- 👤 Seiichi Sakoh
- 👤 Yasuyoshi Muguruma
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 14:01
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/70; A61K9/0012; A61K9/0053; A61K9/006; Y; Y10; Y10T; Y10T428/00; Y10T428/24; Y10T428/24942; Y10T428/2495; Y10T428/24967; Y10T428/24975; Y10T428/25; Y10T428/31504; Y10T428/31971
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
92 words
A sheet-shaped adhesive pharmaceutical preparation capable of adhering within the oral cavity which comprises an adhesive layer containing as essential components a carboxyvinyl polymer, a water-soluble methacrylic copolymer, a polyhydric alcohol and a pharmaceutically active agent, and a water-impermeable and water-insoluble carrier layer containing as essential components a pharmaceutically acceptable water-insoluble, film-forming high molecular weight compound and a plasticizer, wherein the ingredients of the adhesive layer are substantially released from one side of the sheet-shaped preparation whereby the ingredients are absorbed through the mucous membrane, or teethridge to which it is adhered.
Claim 2
Dependent Claim
92 words
A sheet-shaped adhesive pharmaceutical preparation capable of adhering within the oral cavity which comprises an adhesive layer containing as essential components a carboxyvinyl polymer, a water-soluble methacrylic copolymer, a polyhydric alcohol and a pharmaceutically active agent, and a water-impermeable and water-insoluble carrier layer containing as essential components a pharmaceutically acceptable water-insoluble, film-forming high molecular weight compound and a plasticizer, wherein the ingredients of the adhesive layer are substantially released from one side of the sheet-shaped preparation whereby the ingredients are absorbed through the mucous membrane, or teethridge to which it is adhered.
Claim 3
Dependent Claim
21 words
The sheet-shaped adhesive preparation according to claim 1, wherein the water-insoluble, film-forming high molecular weight compound is a water-insoluble cellulose derivative.
Claim 4
Dependent Claim
28 words
The sheet-shaped adhesive preparation according to claim 1, wherein the carboxyvinyl polymer and the waterinsoluble methacrylic copolymer are incorporated in a ratio of 5:1 to 200:1 by weight.
Claim 5
Dependent Claim
48 words
The sheet-shaped adhesive preparation according to claim 1, wherein the adhesive layer has a thickness of 10 to 480 μm and the carrier layer has a thickness of 10 to 200 μm, and the total thickness of the preparation is in the range of 20 to 500 μm.
Claim 6
Dependent Claim
38 words
The adhesive pharmaceutical preparation of claim 1 wherein the water-insoluble methacrylic copolymer used for the adhesive layer is selected from the group consisting of ethyl acrylate-methyl methacrylate-trimethyl-ammonium-ethyl methacrylate chloride polymer, dimethylaminoethyl methacrylate, methyl methacrylate copolymer and mixtures thereof.
Claim 7
Dependent Claim
20 words
The adhesive pharmaceutical preparation of claim 1 wherein the carboxyvinyl polymer is polyacrylic acid or a partially crosslinked product thereof.
Claim 8
Dependent Claim
30 words
The adhesive pharmaceutical preparation of claim 1 wherein the polyhydric alcohol is a member selected from the group consisting of glycerin, propylene glycol, polyethylene glycol, 1,3-butane-diol, sorbitol and mixtures thereof.
Claim 9
Dependent Claim
55 words
The adhesive pharmaceutical preparation of claim 1 wherein the water-insoluble, film-forming high molecular weight compound used for the carrier layer is a member selected from the group consisting of a water-insoluble cellulose derivative having 1.5 or more of degree of substitution of the ethoxy group, cellulose acetate phthalate, hydroxpropyl methyl cellulose pathalate, and mixtures thereof.
Claim 10
Dependent Claim
15 words
The adhesive pharmaceutical preparation of claim 8 wherein the water-insoluble cellulose derivative is ethyl cellulose.
Claim 11
Dependent Claim
32 words
The adhesive pharmaceutical preparation of claim 1 wherein the plasticizer is a member selected from the group consisting of castor oil, triacetin, glycerin, propylene glycol, polyethylene glycol, 1,3-butane-diol, sorbitol and mixtures thereof.
Claim 12
Dependent Claim
27 words
The adhesive pharmaceutical preparation of claim 1 wherein the pharmaceutically active agent is a medicament which can be absorbed from the mucous membrane in the oral cavity.
Claim 13
Dependent Claim
60 words
The adhesive pharmaceutical preparation of claim 11 wherein the medicament is selected from the group consisting of benzodiazepin analogs, psychotropic agents, antispasmodics, antihistamines, steroidal and non-steroidal antiinflammatory agents, cardiotonics, antiarrhythmic agents, diuretics, antihypertensives, vasoconstrictors, vasodilators, nitrate agents, calcium antagonists, antiallergic agents, agents for oral diseases, agents for dental diseases, hormones, vitamins, agents for quitting smoking, antitumor agents, antibiotics, and chemotherapeutics.
Claim 14
Dependent Claim
40 words
The adhesive pharmaceutical preparation of claim 3 wherein the weight of both the carboxyvinyl polymer and the methacrylic copolymer is in the range of 60 to 95 w/w% based on the total weight of all components in the adhesive layer.
Claim 15
Dependent Claim
33 words
The adhesive pharmaceutical preparation of claim 1 wherein the polyhydric alcohol is present in an amount of 5 to 20 w/w% based on the total weight of all components in the adhesive layer.
Claim 16
Dependent Claim
31 words
The adhesive pharmaceutical preparation of claim 1 wherein the pharmaceutically active agent is present in an amount of 1 to 30 w/w% based on the total weight of the adhesive layer.
Claim 17
Dependent Claim
35 words
The adhesive pharmaceutical preparation of claim 1 wherein the water-insoluble, film-forming high molecular weight compound and the plasticizer in the water-inpermeable and water-insoluble carrier layer are incorporated in a weight ratio of 10:1 to 3:2.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-10-23 | 1993-04-24 | 1993-10-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-10-23 | 1997-04-24 | 1997-10-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-10-23 | 2001-04-24 | 2001-10-24 | $7700.00 | Window Closed / Lapsed |