US4539199A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Sustained release pharmaceutical compositions
Assignee: Egyt Gyogyszervegyeszeti Gyar
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Filing: 1982-06-01
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Granted: 1985-09-03
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Expires: 2002-06-01
Abstract
Abstract Pharmaceutical compositions for sustained release of pharmaceutical compounds comprising a reaction product of a water soluble salt of a pharmaceutically active compound containing a primary, secondary or tertiary amino group, and an alkali or ammonium salt of a synthetic copolymer containing an acid group, and selected from the group consisting of methacrylic acid/methacrylic acid methyl ester, methacrylic acid/acrylic acid methyl ester and methacrylic acid/acrylic acid methyl ester/methacrylic acid methyl ester copolymers and a pharmaceutically acceptable excipient. The water soluble salt of a pharmaceutically active compound containing a primary, secondary or tertiary amino group is reacted in aqueous medium with an alkali or ammonium salt of a copolymer selected from the group consisting of the above mentioned copolymers, and the resulting product is converted into a pharmaceutical composition.
Inventors
- 👤 Erno Orban
- 👤 Janos Borvendeg
- 👤 Laszlo Nagy
- 👤 Marta Sotinee Tolvay
- 👤 Erzsebet Bander
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 14:23
CPC Classifications
A; A61; A61K; A61K47/00; A61K47/50; A61K47/51; A61K47/56; A61K47/58
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
81 words
A stable solid pharmaceutical product for the sustained release of a pharmaceutical compound, which is the reaction product of a water soluble salt of a pharmaceutically active compound containing a secondary or tertiary amino group and an alkali or ammonium salt of an acid-group-containing synthetic copolymer selected from the group consisting of 1:1 mole ratio methacrylic acid/methacrylic acid methyl ester, 1:1 mole ratio methacrylic acid/acrylic acid methyl ester and 1:1:1 mole ratio methacrylic acid/acrylic acid methyl ester/methacrylic acid methyl ester copolymers.
Claim 2
Dependent Claim
81 words
A stable solid pharmaceutical product for the sustained release of a pharmaceutical compound, which is the reaction product of a water soluble salt of a pharmaceutically active compound containing a secondary or tertiary amino group and an alkali or ammonium salt of an acid-group-containing synthetic copolymer selected from the group consisting of 1:1 mole ratio methacrylic acid/methacrylic acid methyl ester, 1:1 mole ratio methacrylic acid/acrylic acid methyl ester and 1:1:1 mole ratio methacrylic acid/acrylic acid methyl ester/methacrylic acid methyl ester copolymers.
Claim 3
Dependent Claim
91 words
A stable solid pharmaceutical product for the sustained release of a pharmaceutically active compound, which is a reaction product of a pharmaceutically active compound selected from the group consisting of beta-phenyl-propanol-methylamine hydrochloride, 11(3-dimethylamine-propylidane)-6,11-dihydro-dibenzo[b,e]oxepine hydrochloride, 10-(3'-methylamino-propyl)-2-chloro-phanothiazine hydrochloride, 5-(3-dimethylamino-2-methyl-propyl)-10,11-dihydro-benz[b,f]azepine hydrogenmaleate, 6-methoxy-α-(5-vinyl-2-quinuclidinyl)-4-quinolinemethanole-bisulfate, 1-benzyl-1-(3-dimethylaminopropoxy)cycloheptane hydrogenfumarate, 1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride, 1-(2,5-dichlorophenoxy)-2-hydroxy-3-t-butylaminopropane hydrochloride and an alkali or ammonium salt of an acid-group-containing synthetic copolymer selected from the group consisting of 1:1 mole ratio methacrylic acid/methacrylic acid methyl ester, 1:1 mole ratio methacrylic acid/acrylic acid methyl ester and 1:1:1 mole ratio methacrylic acid/acrylic acid methyl ester/methacrylic acid methyl ester copolymers.
Claim 4
Dependent Claim
91 words
A stable solid pharmaceutical product for the sustained release of a pharmaceutically active compound, which is a reaction product of a pharmaceutically active compound selected from the group consisting of beta-phenyl-propanol-methylamine hydrochloride, 11(3-dimethylamine-propylidane)-6,11-dihydro-dibenzo[b,e]oxepine hydrochloride, 10-(3'-methylamino-propyl)-2-chloro-phanothiazine hydrochloride, 5-(3-dimethylamino-2-methyl-propyl)-10,11-dihydro-benz[b,f]azepine hydrogenmaleate, 6-methoxy-α-(5-vinyl-2-quinuclidinyl)-4-quinolinemethanole-bisulfate, 1-benzyl-1-(3-dimethylaminopropoxy)cycloheptane hydrogenfumarate, 1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride, 1-(2,5-dichlorophenoxy)-2-hydroxy-3-t-butylaminopropane hydrochloride and an alkali or ammonium salt of an acid-group-containing synthetic copolymer selected from the group consisting of 1:1 mole ratio methacrylic acid/methacrylic acid methyl ester, 1:1 mole ratio methacrylic acid/acrylic acid methyl ester and 1:1:1 mole ratio methacrylic acid/acrylic acid methyl ester/methacrylic acid methyl ester copolymers.
Claim 5
Dependent Claim
27 words
A sustained release pharmaceutical product, which is the reaction product of 11-(3-dimethylamino-propylidene)-6,11-dihydro-dibenzo(b,e)oxepine hydrochloride and the sodium salt of 1:1 mole ratio methacrylic acid/methacrylic acid methyl ester copolymer.
Claim 6
Dependent Claim
27 words
A sustained release pharmaceutical product, which is the reaction product of 11-(3-dimethylamino-propylidene)-6,11-dihydro-dibenzo(b,e)oxepine hydrochloride and the sodium salt of 1:1 mole ratio methacrylic acid/methacrylic acid methyl ester copolymer.
Claim 7
Dependent Claim
31 words
A sustained release pharmaceutical product, which is the reaction product of 5-(3-dimethylamino-2-methyl-propyl)-10,11-dihydro-benz(b,f)azepine hydrogen maleate and the potassium salt of 1:1:1 mole ratio methacrylic acid/acrylic acid methyl ester/methacrylic acid methyl ester copolymer.
Claim 8
Dependent Claim
31 words
A sustained release pharmaceutical product, which is the reaction product of 5-(3-dimethylamino-2-methyl-propyl)-10,11-dihydro-benz(b,f)azepine hydrogen maleate and the potassium salt of 1:1:1 mole ratio methacrylic acid/acrylic acid methyl ester/methacrylic acid methyl ester copolymer.
Claim 9
Dependent Claim
27 words
A sustained release pharmaceutical product, which is the reaction product of 6-methoxy-α-(5-vinyl-2-quinuclidinyl)-4-quinoline-methanol bisulfate and the sodium salt of 1:1 mole ratio methacrylic acid/methacrylic acid methyl ester copolymer.
Claim 10
Dependent Claim
27 words
A sustained release pharmaceutical product, which is the reaction product of 6-methoxy-α-(5-vinyl-2-quinuclidinyl)-4-quinoline-methanol bisulfate and the sodium salt of 1:1 mole ratio methacrylic acid/methacrylic acid methyl ester copolymer.
Claim 11
Dependent Claim
27 words
A sustained release pharmaceutical product, which is the reaction product of 1-benzyl-1-(3-dimethylamino-propoxy)-cycloheptane hydrogenfumarate and the sodium salt of 1:1 mole ratio methacrylic acid/methacrylic acid methyl ester copolymer.
Claim 12
Dependent Claim
27 words
A sustained release pharmaceutical product, which is the reaction product of 1-benzyl-1-(3-dimethylamino-propoxy)-cycloheptane hydrogenfumarate and the sodium salt of 1:1 mole ratio methacrylic acid/methacrylic acid methyl ester copolymer.
Claim 13
Dependent Claim
27 words
A sustained release pharmaceutical product which is the reaction product of 1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride and the sodium salt of 1:1 mole ratio methacrylic acid/methacrylic acid methyl ester copolymer.
Claim 14
Dependent Claim
27 words
A sustained release pharmaceutical product which is the reaction product of 1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride and the sodium salt of 1:1 mole ratio methacrylic acid/methacrylic acid methyl ester copolymer.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-09-02 | 1989-03-04 | 1989-09-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-09-02 | 1993-03-04 | 1993-09-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-09-02 | 1997-03-04 | 1997-09-03 | $7700.00 | Window Closed / Lapsed |