EP0184389A2
Expired / Lapsed
EP
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Composition stably containing minocycline for treating periodontal diseases
Assignee: Sunstar Inc
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Filing: 1985-11-28
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Granted: —
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Expires: 2005-11-28
Abstract
Abstract A pharmaceutical composition stably containing minocycline for treating periodontal diseases which comprises minocycline or a pharmaceutically acceptable salt thereof and a base composed of a polyhydric alcohol containing a magnesium compound. Optionally, the base can further contain a water soluble high molecular weight compound, ethyl methacrylate/chlrortrimethylammnonium- ethyl methacrylate copolymer and its solubilizer. A method for treating periodontal diseases comprising topically applying the composition to the oral cavity is also disclosed.
Inventors
- 👤 Kenji Hasegawa
- 👤 Koichi Nakashima
- 👤 Tohru Eguchi
- 👤 Masako Ota
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-26 07:35
CPC Classifications
A; A61; A61Q; A61Q11/00; A61K; A61K31/00; A61K31/65; A61K47/00; A61K47/02; A61K47/06; A61K47/08; A61K47/10; A61K8/00; A61K8/18; A61K8/30; A61K8/40; A61K8/42; A61K9/00; A61K9/0012; A61K9/0053; A61K9/0063
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
31 words
A pharmaceutical composition stably containing minocycline for treating periodontal diseases which comprises minocycline or a pharmaceutically acceptable salt thereof and a base composed of a polyhydric alcohol containing a magnesium compound.
Claim 2
Dependent Claim
31 words
A pharmaceutical composition stably containing minocycline for treating periodontal diseases which comprises minocycline or a pharmaceutically acceptable salt thereof and a base composed of a polyhydric alcohol containing a magnesium compound.
Claim 3
Dependent Claim
28 words
A pharmaceutical composition according to claim 1 wherein the composition contains 0.5 to 10% by weight of the magnesium compound based on the total weight of the composition.
Claim 4
Dependent Claim
34 words
A pharmaceutical composition according to claim 1 or claim 2, wherein the magnesium compound is at least one selected from magnesium chloride, magnesium acetate, magnesium sulfate, magnesium carbonate, magnesium gluconate and a hydrate thereof.
Claim 5
Dependent Claim
36 words
A pharmaceutical composition according to any one of the preceding claims, wherein the polyhydric alcohol is at least one selected from glycerin, ethylene glycol, diethylene glycol, propylene glycol, dipropylene glycol, hexylene glycol, 1,5-pentanediol and 1,3-butylene glycol.
Claim 6
Dependent Claim
39 words
A pharmaceutical composition according to any one of the preceding claims, wherein the base composed of the polyhydric alcohol containing a magnesium compound further includes a water soluble high molecular weight compound, ethyl methacrylate/chlorotrimethylammoniumethyl methacrylate copolymer and a solubiliser.
Claim 7
Dependent Claim
32 words
A pharmaceutical composition according to claim 5, wherein the composition contains 0.2 to 10% by weight of the water soluble high molecular weight compound based on the total weight of the composition.
Claim 8
Dependent Claim
32 words
A pharmaceutical composition according to claim 5 or claim 6, wherein the composition contains 0.5 to 10% by weight of ethyl methacrylate/chlorotrimethylammoniumethyl methacrylate copolymer based on the total weight of the composition.
Claim 9
Dependent Claim
32 words
A pharmaceutical composition according to any one of claims 5 to 7, wherein the composition contains 5 to 25% by weight of the solubiliser based on the total weight of the composition.
Claim 10
Dependent Claim
53 words
A pharmaceutical composition according to any one of claims 5 to 8, wherein the solubiliser is at least one selected from esters of lower polyhydric alcohols and lower fatty acids, esters of lower alcohols and dicarboxylic acids, triacetin, tributyrin, ethylene glycol diacetate, diethyl sebacate, diethyl phthalate, dibutyl phthalate, diisopropyl adipate and dibutyl succinate
Claim 11
Dependent Claim
35 words
A pharmaceutical composition according to any one of claims 5 to 9, wherein the weight ratio of the methacrylate copolymer : the solubiliser is in the range of 1 : 2 to 1 : 25.
Claim 12
Dependent Claim
24 words
A pharmaceutical composition according to any one of claims 1 to 4 wherein the base further includes a water soluble high molecular weight compound.
Claim 13
Dependent Claim
32 words
A pharmaceutical composition according to claim 11, wherein the composition contains 0.2 to 3% by weight of the water soluble high molecular weight compound based on the weight of the polyhydric alcohol.
Claim 14
Dependent Claim
50 words
A pharmaceutical composition according to any one of claims 5 to 12, wherein the water soluble high molecular weight compound is at least one member selected from the group consisting of polyvinyl alcohol, polyvinyl pyrrolidone, carrageenan, locust bean gum, guar gum, hydroxyethyl cellulose, xanthan gum, tragacanth gum, starches and succinoglucan.
Claim 15
Dependent Claim
22 words
A pharmaceutical composition according to any one of the preceding claims, wherein the composition is in the form of a non-aqueous system.
Claim 16
Dependent Claim
30 words
A pharmaceutical composition according to any one of the preceding claims, wherein the composition contains 0.1 to 15% by weight of minocycline based on the total weight of the composition.
Claim 17
Dependent Claim
57 words
A pharmaceutical composition according to claim 1 wherein minocycline, preferably in an amount of 0.1 to 5% by weight based on the total weight of the composition is incorporated into a said base composed of glycerin contaning magnesium chloride, preferably in an amount of 1 to 5% by weight based on the total weight of the composition.
Claim 18
Dependent Claim
11 words
A pharmaceutical composition according to claim 2, wherein the composition comprises:
Claim 21
Independent Claim
38 words
A method of making a pharmaceutical composition, comprising mixing minocycline or a pharmaceutically acceptable salt thereof with at least a polyhydric alcohol and a magnesium compound, to make a composition according to any one of the preceding claims.
Claim 22
Dependent Claim
46 words
A method of making a composition according to claim 5, wherein minocycline or a pharmaceutically acceptable salt thereof is incorporated in to a mixture of the polyhydric alcohol, the magnesium compound, the water soluble high molecular weight compound, ethyl methacrylate/ chlorotrimethylammoniumethyl methacrylate copolymer and a solubiliser.
Claim 23
Dependent Claim
46 words
A method according to claim 19, wherein the minocycline or a pharmaceutically acceptable salt is mixed with a base composed of the polyhydric alcohol, the magnesium compound and the water soluble high molecular weight compound, and a solution of ethyl methacrylate/chlorotrimethylammoniumethyl methacrylate copolymer in the solubiliser.
Claim 24
Dependent Claim
15 words
Use in medicine of a composition according to any one of claims 1 to 17.
Claim 25
Dependent Claim
19 words
Use of a composition according to any one of claims 1 to 17 for the treatment of periodontal disease.
References Cited (Backward Citations)
No citation records indexed.
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