EP0140766A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Intra pocket drug delivery devices for treatment of periondontal diseases
Assignee: ADA Forsyth Institute Inc
•
Filing: 1984-10-04
•
Granted: —
•
Expires: 2004-10-04
Abstract
Abstract Therapeutic agent delivery devices (1) and methods for using them in treatment of dental disease are disclosed. In the treatment of periodontal disease, a therapeutic agent such as tetracycline mixed in a polymeric matrix (1) such as ethylene vinyl acetate copolymer is packed into the area to be treated and kept in place for a suitable time, during which the therapeutic agent diffuses out of the polymeric matrix, providing continuous therapy for the treatment site.
Inventors
- 👤 Max J. Goodson
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 23:49
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0053; A61K9/0063; A61K6/00; A61K6/30; A61C; A61C19/00; A61C19/06; A61C19/063
Claims Analysis
Total Claims: 31
Claim 1
Independent Claim
57 words
A therapeutic agent delivery device suitable for use in the oral cavity, comprising: (a) therapeutic material; and (b) biocompatible polymeric material, said polymeric material containing said therapeutic material and being semipermeable to said therapeutic material, the combination of said therapeutic material and said polymeric material being formable and flexible to conform to the site to be treated.
Claim 2
Dependent Claim
57 words
A therapeutic agent delivery device suitable for use in the oral cavity, comprising: (a) therapeutic material; and (b) biocompatible polymeric material, said polymeric material containing said therapeutic material and being semipermeable to said therapeutic material, the combination of said therapeutic material and said polymeric material being formable and flexible to conform to the site to be treated.
Claim 3
Dependent Claim
78 words
The device of claim 1, wherein the therapeutic material is a therapeutic agent selected from the group of therapeutic agents consisting of antibacterials, antibiotics, antiinflammatory agents, immune-suppressive agents, immune-stimulatory agents, dentinal desensitizers, odor masking agents, immune reagents, anaesthetics, nutritional agents, antioxidants, lipopolysaccharide complexing agents, and peroxides; and the polymeric material is a polymer selected from the group of polymers consisting of collagen, cellulosic polymers, glycolic acid polymers, methacrylates, ethylene vinyl acetate copolymers, ethylene vinyl alcohol copolymers and polycaprolactone.
Claim 4
Dependent Claim
28 words
The device of claim 1, wherein the therapeutic material is tetracycline or a pharmaceutically acceptable acid addition salt thereof; and the polymeric material is an ethylenevinyl acetate copolymer.
Claim 5
Dependent Claim
29 words
The device of claim 2, wherein the therapeutic material is tetracycline or a pharmaceutically acceptable acid addition salt thereof; and the polymeric material is an ethylene vinyl acetate copolymer.
Claim 6
Dependent Claim
29 words
The device of claim 1, wherein the device is a fiber having a diameter of 0.1 to 1 mm, containing 10 to 50 percent by weight of therapeutic material.
Claim 7
Dependent Claim
29 words
The device of claim 2, wherein the device is a fiber having a diameter of 0.1 to 1 mm, containing 10 to 50 percent by weight of therapeutic material.
Claim 8
Dependent Claim
29 words
The device of claim 3, wherein the device is a fiber having a diameter of 0.1 to 1 mm, containing 10 to 50 percent by weight of therapeutic material.
Claim 9
Dependent Claim
50 words
A therapeutic agent delivery device suitable for use in the oral cavity, comprising : an ethylene vinyl acetate copolymer fiber having a diameter of 0.1 to 1 mm, and tetracycline or a pharmaceutically acceptable acid addition salt thereof mixed into said fiber at a levelof 10 to 50% by weight.
Claim 10
Dependent Claim
50 words
A therapeutic agent delivery device suitable for use in the oral cavity, comprising : an ethylene vinyl acetate copolymer fiber having a diameter of 0.1 to 1 mm, and tetracycline or a pharmaceutically acceptable acid addition salt thereof mixed into said fiber at a levelof 10 to 50% by weight.
Claim 11
Independent Claim
75 words
A method for treatment of dental disease comprising the steps of : (a) placing a therapeutic agent delivery device (1), composed of therapeutic material in a biocompatible semipermeable polymeric matrix, at least partially within the site to be treated so that said therapeutic material can diffuse out of said delivery device and provide continuous therapy to the area to be treated; and (b) removing said therapeutic agent delivery device after a suitable time of treatment.
Claim 12
Independent Claim
75 words
A method for treatment of dental disease comprising the steps of : (a) placing a therapeutic agent delivery device (1), composed of therapeutic material in a biocompatible semipermeable polymeric matrix, at least partially within the site to be treated so that said therapeutic material can diffuse out of said delivery device and provide continuous therapy to the area to be treated; and (b) removing said therapeutic agent delivery device after a suitable time of treatment.
Claim 13
Independent Claim
95 words
A method for treatment of dental disease comprising the steps of : (a) placing a therapeutic agent delivery device, composed of an antibiotic in a biocompatible semipermeable polymeric matrix, at least partially within the site to be treated so that said antibiotic can diffuse out of said delivery device and inhibit the growth of all microorganisms in the area to be treated; (b) removing said therapeutic agent delivery device after a suitable time of treatment, so that the treated area will be repopulated subsequently with less pathogenic or nonpathogenic microorganisms from the adjacent oral environment.
Claim 14
Independent Claim
95 words
A method for treatment of dental disease comprising the steps of : (a) placing a therapeutic agent delivery device, composed of an antibiotic in a biocompatible semipermeable polymeric matrix, at least partially within the site to be treated so that said antibiotic can diffuse out of said delivery device and inhibit the growth of all microorganisms in the area to be treated; (b) removing said therapeutic agent delivery device after a suitable time of treatment, so that the treated area will be repopulated subsequently with less pathogenic or nonpathogenic microorganisms from the adjacent oral environment.
Claim 15
Dependent Claim
33 words
The method of claim 10, wherein the dental disease is periodontitis, the antibiotic is tetracycline or a pharmacologically acceptable acid addition salt thereof, and the polymeric matrix is an ethylene vinyl acetate copolymer.
Claim 16
Dependent Claim
27 words
The method of claim 9, further comprising maintaining the therapeutic agent delivery device in position by means of a retaining device covering said therapeutic agent delivery device.
Claim 17
Dependent Claim
27 words
The method of claim 10, further comprising maintaining the therapeutic agent delivery device in position by means of a retaining device covering said therapeutic agent delivery device.
Claim 18
Dependent Claim
27 words
The method of claim 11, further comprising maintaining the therapeutic agent delivery device in position by means of a retaining device covering said therapeutic agent delivery device.
Claim 19
Dependent Claim
14 words
The method of claim 12, wherein the retaining device comprises an inert periodontal dressing.
Claim 20
Dependent Claim
14 words
The method of claim 12, wherein the retaining device comprises a biocompatible polymeric material.
Claim 21
Dependent Claim
13 words
The method of claim 12, wherein the retaining device comprises a metal cap.
Claim 22
Dependent Claim
13 words
The method of claim 12, wherein the retaining device comprises an elastic band.
Claim 23
Dependent Claim
43 words
The method of claim 12, wherein the retaining device comprises biocompatible semipermeable polymeric material and therapeutic material mixed therein, the composition being shaped to perform its retaining function with respect to the primary delivery device, but serving as a secondary delivery device itself.
Claim 24
Dependent Claim
21 words
The method of claim 9, further comprising maintaining the therapeutic agent delivery device in position by means of its intrinsic properties.
Claim 25
Dependent Claim
44 words
The method of claim 10, further comprising maintaining the therapeutic agent delivery device in position by means of its intrinsic properties. 22 . The method of claim 11, further comprising maintaining the therapeutic agent delivery device in position by means of its intrinsic properties.
Claim 26
Dependent Claim
28 words
The method of claim 9, further comprising reducing loss of therapeutic agent from the area being treated, by means of a diffusional barrier covering said area of treatment.
Claim 27
Dependent Claim
28 words
The method of claim 10, further comprising reducing loss of therapeutic agent from the area being treated, by means of a diffusional barrier covering said area of treatment.
Claim 28
Dependent Claim
28 words
The method of claim 11, further comprising reducing loss of therapeutic agent from the area being treated, by means of a diffusional barrier covering said area of treatment.
Claim 29
Dependent Claim
45 words
The method of claim 9, further comprising reducing loss of therapeutic agent from the area being treated, by means of a diffusional barrier intrinsic to the therapeutic agent delivery device and located at the boundary between said therapeutic agent delivery device and the oral environment.
Claim 30
Dependent Claim
45 words
The method of claim 10, further comprising reducing loss of therapeutic agent from the area being treated, by means of a diffusional barrier intrinsic to the therapeutic agent delivery device and located at the boundary between said therapeutic agent delivery device and the oral environment.
Claim 31
Dependent Claim
45 words
The method of claim 11, further comprising reducing loss of therapeutic agent from the area being treated, by means of a diffusional barrier intrinsic to the therapeutic agent delivery device and located at the boundary between said therapeutic agent delivery device and the oral environment.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
Maintenance schedule is calculated for granted US utility patents.