US4554156A
Expired / Lapsed
US
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Wound treating agent
Assignee: Max-Planck-Gesellschaft zur Förderung der Wissenschaften eV
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Filing: 1984-11-26
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Granted: 1985-11-19
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Expires: 2004-11-26
Abstract
Abstract The present invention provides a wound treating agent in powder form based on a swellable organic polymer, which comprises a cross-linked polymer of a hydrophilic acrylic or methacrylic acid derivative, which polymer is permeated by a gellable polysaccharide and/or protein or polypeptide, the agent being obtainable by polymerizing a hydrophilic acrylic or methacrylic acid derivative in the presence of a dissolved, gellable polysaccharide and/or protein or polypeptide and of a cross-linking agent. The present invention also provides a process for the production of this wound treating agent, wherein a hydrophilic acrylic or methacrylic acid derivative is polymerized in an aqueous solution of a gellable polysaccharide and/or protein or polypeptide in the presence of a cross-linking agent and of a conventional polymerization initiator, to give a transparent gel which is dried and pulverized.
Inventors
- 👤 Herbert Fischer
- 👤 Botho Kickhofen
- 👤 Ekkehard Vaubel
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 04:58
CPC Classifications
A; A61; A61L; A61L26/00; A61L26/0061; A61L26/008; A61K; A61K31/00; A61K31/74; A61K31/765; A61K31/78; A61L26/0009; A61L26/0052; A61P; A61P17/00
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
91 words
Wound treating agent in powder form, comprising (a) 50 to 90 percent by weight of a cross-linked polymer of a hydrophilic acrylic or methacrylic acid derivative, and (b) 10 to 50 percent by weight of at least one gellable material selected from the group consisting of polysaccharides, proteins and polypeptides, wherein said polymer is obtained by polymerizing said hydrophilic acrylic or methacrylic acid derivative in the presence of an aqueous solution of component (b) and about 0.5 to about 5 mol percent of a cross-linking agent per mole of monomer employed.
Claim 2
Dependent Claim
91 words
Wound treating agent in powder form, comprising (a) 50 to 90 percent by weight of a cross-linked polymer of a hydrophilic acrylic or methacrylic acid derivative, and (b) 10 to 50 percent by weight of at least one gellable material selected from the group consisting of polysaccharides, proteins and polypeptides, wherein said polymer is obtained by polymerizing said hydrophilic acrylic or methacrylic acid derivative in the presence of an aqueous solution of component (b) and about 0.5 to about 5 mol percent of a cross-linking agent per mole of monomer employed.
Claim 3
Dependent Claim
29 words
Wound treating agent as claimed in claim 1, obtained by polymerizing acrylamide or methacrylamide in the presence of dissolved agar-agar, agarose or gelatine and as a cross-linking agent, N-N'methylene-bisacrylamide.
Claim 4
Dependent Claim
26 words
Wound treating agent as claimed in claim 1 wherein the polysaccharide is agar-agar or agarose and the acrylic or methacrylic acid derivative is acrylamide or methacrylamide.
Claim 5
Dependent Claim
13 words
Wound treating agent as claimed in claim 1 wherein the protein is gelatin.
Claim 6
Dependent Claim
13 words
Wound treating agent as claimed in claim 1 enveloped in a semi-permeable membrane.
Claim 7
Dependent Claim
29 words
Wound treating agent as claimed in claim 1, wherein the agent is in the form of particles the particle size of which is from 0.50 mm. to 0.05 mm.
Claim 8
Dependent Claim
37 words
Wound treating agent as claimed in claim 1 wherein said agent contains 50 to 70% by weight of a polymerized acrylic or methacrylic acid derivative and 50 to 30% by weight of a polysaccharide, protein or polypeptide.
Claim 9
Dependent Claim
19 words
Wound treating agent as claimed in claim 1 wherein the acrylic or methacrylic acid derivative used is an amide.
Claim 10
Dependent Claim
15 words
Wound treating agent as claimed in claim 8 wherein said acrylic acid derivative is acrylamide.
Claim 11
Dependent Claim
15 words
Wound treating agent as claimed in claim 8 wherein said methacrylic acid derivative is methacrylamide.
Claim 12
Dependent Claim
16 words
Wound treating agent as claimed in claim 1 wherein said agent is in a swollen state.
Claim 13
Dependent Claim
20 words
Wound treating agent as claimed in claim 1 further containing medicaments, nutrients, disinfection agents, growth materials, salts and buffer substances.
Claim 14
Dependent Claim
63 words
Process for the production of wound treating agent claimed in claim 1, which comprises polymerizing a hydrophilic acrylic or methacrylic acid derivative in an aqueous solution of a gelable member of the group consisting of polysaccharides, proteins and polypeptides, in the presence of a cross-linking agent and of a polymerization initiator, to give a transparent gel, and drying and pulverizing the transparent gel.
Claim 15
Dependent Claim
13 words
Process as claimed in claim 13, wherein agarose is used as the polysaccharide.
Claim 16
Dependent Claim
12 words
Process according to claim 13, wherein gelatine is used as the protein.
Claim 17
Dependent Claim
19 words
Process according to claim 15, wherein the gel is dried at a temperature of from 30° to 90° C.
Claim 18
Dependent Claim
19 words
Process according to claim 14, wherein the gel is dried at a temperature of from 40° to 80° C.
Claim 19
Dependent Claim
21 words
Process according to claim 17, wherein the gel is dried to a residual water content of less than 10% by weight.
Claim 20
Dependent Claim
15 words
Process according to claim 13, wherein the acrylic or methacrylic acid derivative is an amide.
Claim 21
Dependent Claim
12 words
Process according to claim 19, wherein the acrylic acid derivative is acrylamide.
Claim 22
Dependent Claim
12 words
Process according to claim 19, wherein the methacrylic acid derivative is methacrylamide.
References Cited (Backward Citations)
US3618213A
Cited
DE2725261A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-11-18 | 1989-05-20 | 1989-11-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-11-18 | 1993-05-20 | 1993-11-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-11-18 | 1997-05-20 | 1997-11-19 | $7700.00 | Window Closed / Lapsed |