Patent US5141928A successfully refreshed from Google Patents.
US5141928A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Ophthalmic medication
Assignee: BRUJO Inc
•
Filing: 1989-12-20
•
Granted: 1992-08-25
•
Expires: 2009-12-20
Abstract
Abstract Glycosaminoglycan polysulfates (GAGPS) have been found to be useful in ophthalmic medications in the prevention and treatment of eye injuries. Particularly useful are GAGPS having a molecular weight in the range of 5,000-20,000 daltons. GAGPS-containing ophthalmic medications are usefully combined with an antibiotic in the treatment of ocular fungal or bacterial infections or with an antibiotic in the treatment of fungal or bacteria infections or with an anti-glaucoma agent, such as pilocarpine or epinephrine, in the treatment of glaucoma. Also, of particular usefulness are GAGPS solutions or dispersions used to enhance healing after corneal abrasion or surgical insult.
Inventors
- 👤 Lawrence Goldman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 16:51
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61K31/715; A61K9/00; A61K9/0012; A61K9/0048; A61L; A61L12/00; A61L12/08; A61L12/14; A61L26/00; A61L26/0009; A61L26/0023; A61P; A61P27/00; A61P27/02
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
20 words
A method of treating eye infections which comprises applying to the eye an effective amount of a glycosaminoglycan polysulfate (GAGPS).
Claim 2
Independent Claim
20 words
A method of treating eye infections which comprises applying to the eye an effective amount of a glycosaminoglycan polysulfate (GAGPS).
Claim 3
Dependent Claim
24 words
A method in accordance with claim 1 wherein said GAGPS has a molecular weight in the range from about 5,000 to about 20,000 daltons.
Claim 4
Independent Claim
38 words
A method of treating eye infections which comprises applying to the eye an effective amount of a composition comprising glycosaminoglycan polysulfate (GAGPS) and a medication selected from the group consisting of anti-glaucoma agents and antimicrobial or antibiotic agents.
Claim 5
Independent Claim
38 words
A method of treating eye infections which comprises applying to the eye an effective amount of a composition comprising glycosaminoglycan polysulfate (GAGPS) and a medication selected from the group consisting of anti-glaucoma agents and antimicrobial or antibiotic agents.
Claim 6
Independent Claim
35 words
A method of treating or storing an eye contact lens which comprises immersing said lens or placing said lens in contact with a liquid aqueous solution containing a minor amount of a glycosaminoglycan polysulfate (GAGPS).
Claim 7
Independent Claim
35 words
A method of treating or storing an eye contact lens which comprises immersing said lens or placing said lens in contact with a liquid aqueous solution containing a minor amount of a glycosaminoglycan polysulfate (GAGPS).
Claim 8
Dependent Claim
15 words
A method in accordance with claim 4 wherein said aqueous solution additionally contains a preservative.
Claim 9
Independent Claim
29 words
A method of inhibiting proteolytic enzyme activity in the eye which comprises applying to or contacting the eye with an effective proteolytic enzyme inhibiting amount of glycosaminoglycan polysulfate (GAGPS).
Claim 10
Independent Claim
29 words
A method of inhibiting proteolytic enzyme activity in the eye which comprises applying to or contacting the eye with an effective proteolytic enzyme inhibiting amount of glycosaminoglycan polysulfate (GAGPS).
Claim 11
Dependent Claim
24 words
A method in accordance with claim 6 wherein said GAGPS has a molecular weight in the range from about 5,000 to about 20,000 daltons.
Claim 12
Independent Claim
27 words
A method of treating the eye to promote corneal wound healing which comprises applying to or contacting the eye with an effective amount of a glycosaminoglycan polysulfate
Claim 13
Independent Claim
27 words
A method of treating the eye to promote corneal wound healing which comprises applying to or contacting the eye with an effective amount of a glycosaminoglycan polysulfate
Claim 14
Independent Claim
21 words
A method of healing a damaged cornea which comprises applying to the eye an effective amount of a glycosaminoglycan polysulfate (GAGPS).
Claim 15
Independent Claim
21 words
A method of healing a damaged cornea which comprises applying to the eye an effective amount of a glycosaminoglycan polysulfate (GAGPS).
Claim 16
Independent Claim
38 words
A method of treating a person after cataract surgery involving the removal of a cataract so as to speed corneal healing which comprises administering to the eye after cataract removal an effective amount of a glycosaminoglycan polysulfate (GAGPS).
Claim 17
Independent Claim
38 words
A method of treating a person after cataract surgery involving the removal of a cataract so as to speed corneal healing which comprises administering to the eye after cataract removal an effective amount of a glycosaminoglycan polysulfate (GAGPS).
Claim 18
Independent Claim
28 words
A method of speeding up corneal healing or preventing corneal injury or restoring corneal integrity which comprises applying to the eye an effective amount of glycosaminoglycan polysulfate (GAGPS).
Claim 19
Independent Claim
28 words
A method of speeding up corneal healing or preventing corneal injury or restoring corneal integrity which comprises applying to the eye an effective amount of glycosaminoglycan polysulfate (GAGPS).
Claim 20
Independent Claim
41 words
A method of treating eye infections or ocular diseases which comprises directly apply to the eye a sterile dispersion or solution of glycosaminoglycan polysulfate (GAGPS), said GAGPS having a molecular weight in the range from about 5,000 to about 20,000 daltons.
Claim 21
Independent Claim
41 words
A method of treating eye infections or ocular diseases which comprises directly apply to the eye a sterile dispersion or solution of glycosaminoglycan polysulfate (GAGPS), said GAGPS having a molecular weight in the range from about 5,000 to about 20,000 daltons.
References Cited (Backward Citations)
US3710796A
Cited
US4500519A
Cited
US4692435A
Cited
US4774231A
Cited
US4524066A
Cited
US4489065A
Cited
US4699900A
Cited
US4908354A
Cited
US4710493A
Cited
US4812448A
Cited
US4713373A
Cited
US4818690A
Cited
US4931279A
Cited
US4861760A
Cited
US4870166A
Cited
US4840941A
Cited
US4820693A
Cited
US4826826A
Cited
US4814437A
Cited
US4885361A
Cited
US4966894A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-08-25 | 1996-02-24 | 1996-08-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-08-25 | 2000-02-24 | 2000-08-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-08-25 | 2004-02-24 | 2004-08-25 | $7700.00 | Window Closed / Lapsed |