US4713373A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Xylan sulfates of low molecular weight, process for their preparation and medicaments containing them
Assignee: Sanofi SA
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Filing: 1985-10-31
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Granted: 1987-12-15
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Expires: 2005-10-31
Abstract
Abstract The present invention relates to novel xylan sulfates of average molecular weight comprised between 2000 and 5000 Daltons. The invention also relates to their process of preparation by fractionation and their use in therapeutics as orally active antithrombotic and hypolipaemic agents.
Inventors
- 👤 Alain Bayol
- 👤 Francis Blanc
- 👤 Jacqueline Lansen
- 👤 Jean-Pierre Maffrand
- 👤 Jean-Marie Pereillo
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 21:21
CPC Classifications
C; C08; C08B; C08B37/00; C08B37/0006; C08B37/0057; A; A61; A61P; A61P3/00; A61P3/06; A61P7/00; A61P7/02
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
37 words
Xylan sulfates having an average degree of sulfation of from 1.5 to 2, from 0 to 10 percent uronic acid, from 30 to 40 percent pentroses and an average molecular weight of from 2000 to 5000 daltons.
Claim 2
Dependent Claim
37 words
Xylan sulfates having an average degree of sulfation of from 1.5 to 2, from 0 to 10 percent uronic acid, from 30 to 40 percent pentroses and an average molecular weight of from 2000 to 5000 daltons.
Claim 3
Dependent Claim
27 words
The xylan sulfates of claim 1 having a 1.88 degree of sulfation, 6 percent uronic acid, 31.4 percent pentoses and an average molecular weight of 3346 daltons.
Claim 4
Dependent Claim
23 words
The xylan sulfates of claim 1 having a 1.8 degree of sulfation, 4.3 percent pentoses and an average molecular weight of 3518 daltons.
Claim 5
Dependent Claim
27 words
The xylan sulfates of claim 1 having a 1.93 degree of sulfation, 4.9 percent uronic acid, 38 percent pentoses and an average molecular weight of 3889 daltons.
Claim 6
Dependent Claim
26 words
The xylan sulfates of claim 1 having 1.85 degree of sulfation, 5.1 percent uronic acid, 34.3 percent pentoses and an average molecular weight of 3939 daltons.
Claim 7
Dependent Claim
26 words
The xylan sulfates of claim 1 having 1.82 degree of sulfation, 4.3 percent uronic acid, 34.5 percent pentoses and an average molecular weight of 4066 daltons.
Claim 8
Dependent Claim
26 words
The xylan sulfates of claim 1 having 1.90 degree of sulfation, 4.7 percent uronic acid, 35.8 percent pentoses and an average molecular weight of 4407 daltons.
Claim 9
Dependent Claim
26 words
The xylan sulfates of claim 1 having 1.80 degree of sulfation, 5.3 percent uronic acid, 35.2 percent pentoses and an average molecular weight of 4674 daltons.
Claim 10
Dependent Claim
26 words
The xylan sulfates of claim 1 having 1.98 degree of sulfation, 4.6 percent uronic acid, 30.8 percent pentoses and an average molecular weight of 4903 daltons.
Claim 11
Dependent Claim
26 words
The xylan sulfates of claim 1 having 2.0 degree of sulfation, 5.7 percent uronic acid, 34.7 percent pentoses and an average molecular weight of 4921 daltons.
Claim 12
Dependent Claim
25 words
A therapeutic composition with antithrombotic and hypolipemic activity which comprises a therapeutically acceptable carrier and an effective amount of the xylan sulfates of claim 1.
Claim 13
Dependent Claim
12 words
The therapeutic composition of claim 11 which is suitable for oral administration.
Claim 14
Dependent Claim
12 words
The therapeutic composition of claim 11 which is suitable for parenteral administration.
Claim 15
Dependent Claim
12 words
The therapeutic composition of claim 11 which is suitable for rectal administration.
Claim 16
Dependent Claim
12 words
The therapeutic composition of claim 11 which is suitable for local administration.
Claim 17
Dependent Claim
26 words
The therapeutic composition of claim 11 which is in the form of a unit dose containing from 0.030 g to 1.00 g of a active principle.
Claim 18
Dependent Claim
103 words
A process for the preparation of xylan sulfates having a degree of sulfation from 1.5 to 2, from 10 percent uronic acid, from 30 to 40 percent pentoses and an average molecular weight of from 2000 to 5000 daltons which process comprises mixing xylan sulfates having a molecular weight in the range of 1,000 to 40,000 daltons in a liquid medium, separating the liquid medium which contains the xylan sulfates having a molecular weight of greater than about 2,000 daltons and less than about 5,000 daltons, removing the liquid medium, and obtaining xylan sulfates having molecular weight of from 2,000 to 5,000 daltons.
Claim 19
Dependent Claim
103 words
A process for the preparation of xylan sulfates having a degree of sulfation from 1.5 to 2, from 10 percent uronic acid, from 30 to 40 percent pentoses and an average molecular weight of from 2000 to 5000 daltons which process comprises mixing xylan sulfates having a molecular weight in the range of 1,000 to 40,000 daltons in a liquid medium, separating the liquid medium which contains the xylan sulfates having a molecular weight of greater than about 2,000 daltons and less than about 5,000 daltons, removing the liquid medium, and obtaining xylan sulfates having molecular weight of from 2,000 to 5,000 daltons.
Claim 20
Dependent Claim
65 words
The process of claim 17 wherein the liquid medium containing xylan sulfates having a molecular weight greater than about 2,000 daltons and less than about 5,000 daltons is separated by the ultrafiltration steps of (1 ) passing the liquid medium through a membrane having a cutoff threshold of 5,000 and (2) passing the liquid medium through a membrane having a cutoff threshold of 2,000 daltons.
References Cited (Backward Citations)
US4524066A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-12-14 | 1991-06-15 | 1991-12-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-12-14 | 1995-06-15 | 1995-12-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-12-14 | 1999-06-15 | 1999-12-15 | $7700.00 | Window Closed / Lapsed |