Disaccharides formed by patterns having a glucosamine and uronic acid structure, preparation thereof and biological applications

Claim 1

A process for synthesizing a heparinic disaccharide which process comprises the steps of condensing I with II ##STR8## wherein Y groups Y 1 , Y 2 , Y 3 , Y 4 , and Y 5 are selected from the group consisting of a precursor to an SO 3 group, and a precursor to an OH group, wherein at least one Y group is a precursor to an SO 3 group and at least one Y group is a precursor to an OH group, wherein the precursor to an OH group is stable and does not migrate to other carbon positions during removal of the Y groups which are the precursor to an SO 3 group and during the introduction of SO 3 groups to replace the Y groups which are the precursor to an SO 3 group, further wherein R 1 is a protecting group which forms an ester at the carboxyl group, which protecting group is removable following removal of Y groups which are the precusor to an OH group, further wherein R is an inert protecting group, which protecting group is stable during removal of the other protecting groups, further wherein R 2 is a reactive group, which reactive group allows the formation of a 1-4 alpha type linkage during the condensation, further wherein R 3 is an OH group, further wherein D is a nitrogen containing group, which nitrogen containing group is a precursor to an amine, wherein the process further comprises the steps of removing the Y groups which are the precursor to an SO 3 group, substituting SO 3 groups at the carbon positions left free thereby, removing the Y groups which are the precursor to an OH group and converting the nitrogen containing group into an amine.