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US4607025A
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Disaccharides having a glucosamine and uronic acid structure, and biological applications thereof
Assignee: Choay SA
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Filing: 1982-12-20
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Granted: 1986-08-19
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Expires: 2002-12-20
Abstract
Abstract 1,4 α disaccharides of formula: ##STR1## with Z representing a nitrogenous functional group, M hydrogen or a sulphate or acetyl group, R an alkyl radical of 1 to 4 carbon atoms and A a functional group such as an acid group, or a derivative.
Inventors
- 👤 Maurice Petitou
- 👤 Pierre Sinay
- 👤 Jean Choay
- 👤 Jean-Claude Lormeau
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 04:55
CPC Classifications
C; C07; C07H; C07H3/00; C07H3/04; A; A61; A61P; A61P7/00; A61P7/02
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
30 words
A disaccharide of the formula ##STR8## wherein M is hydrogen, --SO 3 Na or acetyl; Z is --SO 3 Na or acetyl and R 1 is hydrogen, methyl or sodium.
Claim 2
Dependent Claim
30 words
A disaccharide of the formula ##STR8## wherein M is hydrogen, --SO 3 Na or acetyl; Z is --SO 3 Na or acetyl and R 1 is hydrogen, methyl or sodium.
Claim 3
Dependent Claim
16 words
The disaccharide of claim 1 wherein M is --SO 3 Na and R 1 is sodium.
Claim 4
Dependent Claim
21 words
The disaccharide of claim 1 wherein Z is --SO 3 Na, M is --SO 3 Na and R 1 is Na.
Claim 5
Dependent Claim
85 words
A disaccharide of the formula ##STR9## wherein Z is --N 3 , --NH 2 , --NHCOCH 3 or --NHSO 3 M 2 ; R is alkyl from 1 to 4 carbons or aryl from 6 to 7 carbons; R 1 is hydrogen, alkyl from 1 to 4 carbons or a metal; R 2 is hydrogen or benzyl; M is hydrogen, acetyl or --SO 3 M 1 ; and M 1 and M 2 may be the same or different and are an alkali metal cation.
Claim 6
Dependent Claim
85 words
A disaccharide of the formula ##STR9## wherein Z is --N 3 , --NH 2 , --NHCOCH 3 or --NHSO 3 M 2 ; R is alkyl from 1 to 4 carbons or aryl from 6 to 7 carbons; R 1 is hydrogen, alkyl from 1 to 4 carbons or a metal; R 2 is hydrogen or benzyl; M is hydrogen, acetyl or --SO 3 M 1 ; and M 1 and M 2 may be the same or different and are an alkali metal cation.
Claim 7
Dependent Claim
30 words
The compound of claim 4 wherein M is hydrogen, --SO 3 Na, or acetyl, Z is --N 3 , R 2 is benzyl, and R and R 1 are methyl.
Claim 8
Dependent Claim
27 words
The compound of claim 4 wherein M is --SO 3 Na, Z is --NH 2 , R 2 is hydrogen and R and R 1 are methyl.
Claim 9
Dependent Claim
33 words
The compound of claim 4 wherein M is --SO 3 Na, Z is --NHCOCH 3 or --NHSO 3 Na, R is methyl, R 1 is methyl or sodium and R 2 is hydrogen.
Claim 10
Dependent Claim
15 words
The compound of claim 7 wherein Z is --NHCOCH 3 and R 1 is methyl.
Claim 11
Dependent Claim
15 words
The compound of claim 7 wherein Z is --NHCOCH 3 and R 1 is sodium.
Claim 12
Dependent Claim
16 words
The compound of claim 7 wherein Z is --NHSO 3 Na and R 1 is methyl.
Claim 13
Dependent Claim
29 words
A biological composition which comprises a biologically acceptable carrier and in a therapeutically effective amount, a disaccharide of claims 1, 2, 4, 5, 6, 7, 8, 9 or 10.
Claim 14
Dependent Claim
25 words
A therapeutic method for controlling thrombosis in a patient which comprises administering to said patient the therapeutic composition of claim 11 and thereby controlling thrombosis.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-08-18 | 1990-02-17 | 1990-08-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-08-18 | 1994-02-17 | 1994-08-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-08-18 | 1998-02-17 | 1998-08-19 | $7700.00 | Window Closed / Lapsed |