US4489065A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Chondroitin drug Complexes
Assignee: Future Labs Inc
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Filing: 1982-06-30
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Granted: 1984-12-18
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Expires: 2002-06-30
Abstract
Abstract A chondroitin or a chondroitin sulfate covalently or ionically bonded to a drug substance of the group consisting of chloramphenicol, methotrexate, adriamycin, vinblastine, vincristine, vindesine, 6-mercaptopurine, 5-fluorouracil, the penicillin antibiotics, the cephalosporin antibiotics, and the 1-oxacephalosporin antibiotics to form a prodrug which, when injected into animal tissue, undergoes natural conversion in the physiological environment to provide controlled release of the drug or an active drug complex.
Inventors
- 👤 Alan G. Walton
- 👤 Randall V. Sparer
- 👤 Nnochiro Ekwuribe
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 20:24
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61K31/715; A61K47/00; A61K47/50; A61K47/51; A61K47/56; A61K47/61; C; C08; C08B; C08B37/00; C08B37/006; C08B37/0063; C08B37/0069
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
71 words
A prodrug consisting essentially of chondroitin-4-sulfate or chondroitin-6-sulfate covalently or ionically bonded to a pharmaceutically active substance of the group consisting of chloramphenicol, methotrexate, adriamycin, vinblastine, vincristine, vindesine, 6-mercaptopurine, 5-fluorouracil, the penicillin antibiotics, the cephalosporin antibiotics, and the 1-oxacephalosporin antitiotics and having the property, when injected into animal tissue, of undergoing natural conversion in the physiological environment to provide controlled release of the pharmaceutically active substance or an active complex thereof.
Claim 2
Dependent Claim
71 words
A prodrug consisting essentially of chondroitin-4-sulfate or chondroitin-6-sulfate covalently or ionically bonded to a pharmaceutically active substance of the group consisting of chloramphenicol, methotrexate, adriamycin, vinblastine, vincristine, vindesine, 6-mercaptopurine, 5-fluorouracil, the penicillin antibiotics, the cephalosporin antibiotics, and the 1-oxacephalosporin antitiotics and having the property, when injected into animal tissue, of undergoing natural conversion in the physiological environment to provide controlled release of the pharmaceutically active substance or an active complex thereof.
Claim 3
Dependent Claim
13 words
A prodrug as in claim 1 wherein said pharmaceutically active substance is chloramphenicol.
Claim 4
Dependent Claim
15 words
A prodrug as in claim 1 wherein said pharmaceutically active substance is a penicillin antibiotic.
Claim 5
Dependent Claim
15 words
A prodrug as in claim 1 wherein said pharmaceutically active substance is a cephalosporin antibiotic.
Claim 6
Dependent Claim
13 words
A prodrug as in claim 1 wherein said pharmaceutically active substance is adriamycin.
Claim 7
Dependent Claim
13 words
A prodrug as in claim 1 wherein said pharmaceutically active substance is methotrexate.
Claim 8
Dependent Claim
13 words
A prodrug as in claim 1 wherein said pharmaceutically active substance is vinblastine.
Claim 9
Dependent Claim
13 words
A prodrug as in claim 1 wherein said pharmaceutically active substance is vincristine.
Claim 10
Dependent Claim
13 words
A prodrug as in claim 1 wherein said pharmaceutically active substance is vindesine.
Claim 11
Dependent Claim
13 words
A prodrug as in claim 1 wherein said pharmaceutically active substance is 6-mercaptopurine.
Claim 12
Dependent Claim
12 words
A prodrug as in claim 2, said prodrug being chondroitin-4-sulfate chloramphenicol ester.
Claim 13
Dependent Claim
12 words
A prodrug as in claim 2, said prodrug being chrondroitin-6-sulfate chloramphenicol ester.
Claim 14
Dependent Claim
12 words
A prodrug as in claim 6, said prodrug being chondroitin-4-sulfate methotrexate amide.
Claim 15
Dependent Claim
12 words
A prodrug as in claim 6, said prodrug being chondroitin-6-sulfate methotrexate amide.
Claim 16
Dependent Claim
14 words
A prodrug as in claim 6, said prodrug being chondroitin-4-sulfate ionically bonded to methotrexate.
Claim 17
Dependent Claim
14 words
A prodrug as in claim 6, said prodrug being chondroitin-6-sulfate ionically bonded to methotrexate.
Claim 18
Dependent Claim
12 words
A prodrug as in claim 5, said prodrug being chondroitin-4-sulfate adriamycin amide.
Claim 19
Dependent Claim
12 words
A prodrug as in claim 5, said prodrug being chondroitin-6-sulfate adriamycin amide.
Claim 20
Dependent Claim
13 words
A prodrug as in claim 3, said prodrug being chondroitin-4-sulfate penicillin V ester.
Claim 21
Dependent Claim
13 words
A prodrug as in claim 5, said prodrug being chondroitin-4-sulfate adriamycin ionic complex.
Claim 22
Dependent Claim
13 words
A prodrug as in claim 1 wherein said pharmaceutically active substance is 5-fluorouracil.
References Cited (Backward Citations)
GB1305807A
Cited
US4105760A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-12-18 | 1988-06-18 | 1988-12-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-12-18 | 1992-06-18 | 1992-12-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-12-18 | 1996-06-18 | 1996-12-18 | $7700.00 | Window Closed / Lapsed |