Abstract Local anesthesia is induced using microdroplets of a general anesthetic in liquid form. As an example, microdroplets of the general anesthetic methoxyfluorane coated by a unimolecular layer of dimysistoyl phosphatidylcholine are prepared by sonication. The microdroplets so prepared remain stable in physiologically-compatible solution, and are suitable for injection, typically intradermally or intraveneously, into a patient for inducing local anesthesia. These methoxyflurane-containing microdroplets have been demonstrated to cause long-term local anesthesia when injected intradermally, giving duration of anesthesia 28 times longer than with other anesthetics, such as lidocaine and 11 times longer than with bupivacaine.
A method of inducing local anesthesia in a subject in need of same comprising administering intradermally or intramuscularly in the area of the subject in which local anesthesia is desired a local anesthesia-inducing amount of microdroplets of a general anesthetic consisting of a fluoro-chloro-hydrocarbon in liquid form which is stabilized against coalescence and surrounded by a unimolecular phospholipid layer said microdroplets being from about 200 Angstroms up to 10,000 Angstroms in diameter.
Claim 2
Independent Claim
72 words
A method of inducing local anesthesia in a subject in need of same comprising administering intradermally or intramuscularly in the area of the subject in which local anesthesia is desired a local anesthesia-inducing amount of microdroplets of a general anesthetic consisting of a fluoro-chloro-hydrocarbon in liquid form which is stabilized against coalescence and surrounded by a unimolecular phospholipid layer said microdroplets being from about 200 Angstroms up to 10,000 Angstroms in diameter.
Claim 3
Dependent Claim
22 words
The method of claim 1 in which the general anesthetic is selected from the group consisting of halothane, isoflurane, enflurane, and methoxyflurane.
Claim 4
Dependent Claim
12 words
The method of claim 2 in which the general anesthetic is methoxyflurane.