US4320121A
Expired / Lapsed
US
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Method of emulsifying cholesterol, cholesterol esters and triglyceride compounds
Assignee: LIPID SPECIALTIES Inc A CORP OF
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Filing: 1979-11-05
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Granted: 1982-03-16
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Expires: 1999-11-05
Abstract
Abstract A method of emulsifying water insoluble compounds particularly cholesterol, cholesterol esters and triglycerides in the blood which method comprises emulsifying the water insoluble compound with a novel synthetic phosphatidyl quaternary ammonium, sulfonium and phosphonium hydroxide compounds or emulsifying agents which compounds have a hydrophobic/hydrophilic balance different from the natural phosphatidylcholine, by changes in the polar group.
Inventors
- 👤 Barry D. Sears
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:25
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/66; A61K31/683; A61K31/685; A61K47/00; A61K47/06; A61K47/24; A61K9/00; A61K9/0012; A61K9/0019; B; B82; B82Y; B82Y5/00; C; C07; C07F; C07F9/00; C07F9/02; C07F9/06; C07F9/08; C07F9/09; C07F9/10; C07F9/28; C07F9/54; C07F9/5407; Y; Y10; Y10T; Y10T428/00; Y10T428/29; Y10T428/2982; Y10T428/2984
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
86 words
A method of emulsifying a water-insoluble compound to form a mixed micelle product, which method comprises: admixing a water-insoluble compound, selected from the group consisting of water-insoluble compounds of cholesterol, cholesterol esters and triglycerides, with a synthetic quaternary-ammonium phosphatidyl compound having the general structural formula: ##STR4## wherein ##STR5## is a long-chain fatty-acid radical; R 1 , R 2 and R 3 are alkyl radicals, which alkyl radicals have in total four or more carbon atoms; and R 4 is a C 1 -C 10 polymethylene radical.
Claim 2
Independent Claim
86 words
A method of emulsifying a water-insoluble compound to form a mixed micelle product, which method comprises: admixing a water-insoluble compound, selected from the group consisting of water-insoluble compounds of cholesterol, cholesterol esters and triglycerides, with a synthetic quaternary-ammonium phosphatidyl compound having the general structural formula: ##STR4## wherein ##STR5## is a long-chain fatty-acid radical; R 1 , R 2 and R 3 are alkyl radicals, which alkyl radicals have in total four or more carbon atoms; and R 4 is a C 1 -C 10 polymethylene radical.
Claim 3
Dependent Claim
56 words
The method of claim 1 which includes admixing the water-insoluble compound and the synthetic quaternary-ammonium phosphatidyl compound in the presence of a volatile organic solvent, evaporating the solvent to form a dried mixture, and, thereafter, adding water to the dried mixture, to form a mixed micelle composed of the synthetic phosphatidyl compound and the water-insoluble compound.
Claim 4
Dependent Claim
42 words
The method of claim 1 which includes the preparation of an organic solvent solution containing the water-insoluble compound and the phosphatidyl compound, and injecting the solvent solution into water to form a mixed micelle compound, and, thereafter, recovering the mixed micelle compound.
Claim 5
Dependent Claim
32 words
The method of claim 1 which includes adding the synthetic quaternary-ammonium phosphatidyl compound to an aqueous suspension of the water-insoluble compound, and, thereafter, homogenizing the mixture to form a mixed micelle compound.
Claim 6
Dependent Claim
21 words
The method of claim 3 wherein the organic solvent is selected from the group consisting of methanol, ethanol, dioxane and ether.
Claim 7
Dependent Claim
16 words
The method of claim 1 wherein the R is a C 14 -C 20 fatty-acid radical.
Claim 8
Dependent Claim
32 words
The method of claim 1 wherein R 4 is a C 2 -C 5 methylene chain, and R 1 , R 2 and R 3 are C 2 -C 4 alkyl radicals.
Claim 9
Dependent Claim
28 words
The method of claim 1 wherein the synthetic phosphatidyl is selected from the group of: dioleoyl phosphatidyl-(methylethylene-N-triethyl) ammonium; dipalmitoyl phosphatidyl-(ethylene-N-dimethylethyl) ammonium; distearoyl phosphatidyl-(ethylene-N-dimethylethyl) ammonium; and oleoyl-palmitoyl phosphatidyl-(ethylene-N-dimethylethyl) ammonium.
Claim 10
Dependent Claim
11 words
The mixed micelle product produced by the method of claim 8.
Claim 11
Dependent Claim
11 words
The mixed micelle product produced by the method of claim 1.
Claim 12
Dependent Claim
42 words
The mixed micelle product produced by the method of claim 1, wherein ##STR6## is a C 14 -C 20 fatty-acid radical and R 4 is trimethylene, and R 1 and R 2 are methyl radicals and R 3 is an ethyl radical.
Claim 13
Dependent Claim
27 words
The method of claim 1 wherein ##STR7## is selected from the group of fatty-acid radicals of oleic, stearic, myristic, palmitic, egg yolk, soybean, linoleic and combinations thereof.
Claim 14
Dependent Claim
21 words
The method of claim 1 wherein R 1 and R 2 are methyl radicals and R 3 is an ethyl radical.
Claim 15
Dependent Claim
19 words
The method of claim 1 wherein R 1 , R 2 and R 3 are the same alkyl radicals.
Claim 16
Dependent Claim
16 words
The method of claim 1 wherein R 4 is a C 2 -C 5 methylene radical.
References Cited (Backward Citations)
US2853419A
Cited
US4159988A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-03-15 | 1985-09-14 | 1986-03-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-03-15 | 1989-09-14 | 1990-03-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-03-15 | 1993-09-14 | 1994-03-16 | $7700.00 | Window Closed / Lapsed |