US4159988A
Expired / Lapsed
US
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Synthetic phospholipids, a process for their manufacture and their use
Assignee: Max-Planck-Gesellschaft zur Förderung der Wissenschaften eV
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Filing: 1978-01-18
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Granted: 1979-07-03
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Expires: 1998-01-18
Abstract
Abstract Synthetic phospholipids having a varying phosphorus-nitrogen distance and a process for their manufacture are disclosed.
Inventors
- 👤 Hansjorg Eibl
- 👤 Walter Diembeck
- 👤 Stephen Kovatchev
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 16:51
CPC Classifications
C; C07; C07F; C07F9/00; C07F9/02; C07F9/06; C07F9/08; C07F9/09; C07F9/10; A; A61; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/55; A61K8/553; A61Q; A61Q19/00
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
84 words
A synthetic phospholipid prepared by reacting an aliphatic or cycloaliphatic polyhydroxy compound having one free hydroxy group, the remaining hydroxy groups being protected, with an ω-haloalkylphosphoric acid dichloride of the formula ##STR10## wherein X is fluorine, chlorine, bromine, or iodine, and then reacting the resulting reaction product with an amine of the formula ##STR11## wherein R 1 , R 2 , and R 3 are each hydrogen or methyl, the improvement wherein Alk is alkyl or cycloalkyl having from 6 to 16 carbon atoms.
Claim 2
Dependent Claim
84 words
A synthetic phospholipid prepared by reacting an aliphatic or cycloaliphatic polyhydroxy compound having one free hydroxy group, the remaining hydroxy groups being protected, with an ω-haloalkylphosphoric acid dichloride of the formula ##STR10## wherein X is fluorine, chlorine, bromine, or iodine, and then reacting the resulting reaction product with an amine of the formula ##STR11## wherein R 1 , R 2 , and R 3 are each hydrogen or methyl, the improvement wherein Alk is alkyl or cycloalkyl having from 6 to 16 carbon atoms.
Claim 3
Dependent Claim
2 words
SN-1,2-dipalmitoylglycerol-3-phosphoric acid-5-trimethylaminopentylester.
Claim 4
Dependent Claim
2 words
SN-1,2-dipalmitoylglycerol-3-phosphoric acid-5-trimethylaminopentylester.
Claim 5
Dependent Claim
2 words
SN-1-palmitoylglycerol-3-phosphoric acid-5-trimethylaminopentylester.
Claim 6
Dependent Claim
2 words
SN-1-palmitoylglycerol-3-phosphoric acid-5-trimethylaminopentylester.
Claim 7
Dependent Claim
2 words
1,2,3,4,5-pentamyristoyl-D-mannitol-6-phosphoric acid-7-trimethylaminoheptylester.
Claim 8
Dependent Claim
2 words
1,2,3,4,5-pentamyristoyl-D-mannitol-6-phosphoric acid-7-trimethylaminoheptylester.
Claim 9
Dependent Claim
2 words
1-pelmitoyl-2-hexadecyletherglycerol-3-phosphoric acid-9-trimethylaminononylester.
Claim 10
Dependent Claim
2 words
1-pelmitoyl-2-hexadecyletherglycerol-3-phosphoric acid-9-trimethylaminononylester.
Claim 11
Dependent Claim
2 words
1,3-diectyletherglycerol-2-phosphoric acid-6-trimethylaminohexylester.
Claim 12
Dependent Claim
2 words
1,3-diectyletherglycerol-2-phosphoric acid-6-trimethylaminohexylester.
Claim 13
Dependent Claim
2 words
1,2-dipentadecylketoneglycerol-3-phosphoric acid-6-trimethylaminohexylester.
Claim 14
Dependent Claim
2 words
1,2-dipentadecylketoneglycerol-3-phosphoric acid-6-trimethylaminohexylester.
Claim 15
Dependent Claim
2 words
1-myristoyl-propanediol-3-phosphoric acid-4-trimethylaminobutylester.
Claim 16
Dependent Claim
2 words
1-myristoyl-propanediol-3-phosphoric acid-4-trimethylaminobutylester.
Claim 17
Dependent Claim
2 words
1-tetradecyletherpropanediol-3-phosphoric acid-4-trimethylaminobutylester.
Claim 18
Dependent Claim
2 words
1-tetradecyletherpropanediol-3-phosphoric acid-4-trimethylaminobutylester.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-07-02 | 1983-01-01 | 1983-07-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-07-02 | 1987-01-01 | 1987-07-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-07-02 | 1991-01-01 | 1991-07-03 | $7700.00 | Window Closed / Lapsed |