US4331654A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Magnetically-localizable, biodegradable lipid microspheres
Assignee: Eli Lilly and Co
•
Filing: 1980-06-13
•
Granted: 1982-05-25
•
Expires: 2000-06-13
Abstract
Abstract Drug carrier formulation consisting of magnetically-localizable, biodegradable lipid microspheres.
Inventors
- 👤 Robert M. Morris
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 14:53
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/48; A61K9/50; A61K9/5094; G; G01; G01N; G01N2446/00; G01N2446/20; G01N2446/80
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
28 words
A magnetically-localizable, biodegradable, substantially water-free drug carrier formulation consisting essentially of lipid microspheres containing a magnetically-responsive substance, one or more biodegradable lipids and one or more non-toxic surfactants.
Claim 2
Dependent Claim
28 words
A magnetically-localizable, biodegradable, substantially water-free drug carrier formulation consisting essentially of lipid microspheres containing a magnetically-responsive substance, one or more biodegradable lipids and one or more non-toxic surfactants.
Claim 3
Dependent Claim
14 words
Microspheres according to claim 1 in which the magnetically-responsive substance is finely divided magnetite.
Claim 4
Dependent Claim
18 words
Microspheres according to claim 2 in which the magnetite particles have an average size less than 1000 A.
Claim 5
Dependent Claim
22 words
Microspheres according to claim 1 in which one of the lipids is a fatty acid having an even number of carbon atoms.
Claim 6
Dependent Claim
11 words
Microspheres according to claim 1 melting in the range 30°-100° C.
Claim 7
Dependent Claim
14 words
Microspheres according to claim 1 in which one or more non-ionic surfactants is employed.
Claim 8
Dependent Claim
15 words
Microspheres according to claim 1 in which the average particle size is less than 4μ.
Claim 9
Dependent Claim
11 words
Microspheres according to claim 1 of less than 5μ in diameter.
Claim 10
Dependent Claim
32 words
Microspheres according to claim 1 comprising palmitic acid, magnetite particles of average size less than 1000 A, lecithin and polyoxy ethylene sorbitan mono-oleate having an average size of less than about 4μ.
Claim 11
Dependent Claim
41 words
A magnetically-localizable, biodegradable drug carrier formulation consisting of a lipid soluble drug dispersed in lipid microspheres, substantially free of water, said lipid microspheres being composed of one or more biodegradable lipids, a magnetically responsive substance and one or more non-toxic surfactants.
Claim 12
Dependent Claim
41 words
A magnetically-localizable, biodegradable drug carrier formulation consisting of a lipid soluble drug dispersed in lipid microspheres, substantially free of water, said lipid microspheres being composed of one or more biodegradable lipids, a magnetically responsive substance and one or more non-toxic surfactants.
Claim 13
Dependent Claim
16 words
A drug carrier formulation according to claim 10 in which the drug is an oncolytic agent.
References Cited (Backward Citations)
US2671451A
Cited
US2971916A
Cited
US3057344A
Cited
US3042616A
Cited
US3190837A
Cited
US3137631A
Cited
US3159545A
Cited
US3474777A
Cited
US3937668A
Cited
US3725113A
Cited
US3960757A
Cited
US4147767A
Cited
US4115534A
Cited
DE2656317A1
Cited
US4247406A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-05-24 | 1985-11-23 | 1986-05-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-05-24 | 1989-11-23 | 1990-05-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-05-24 | 1993-11-23 | 1994-05-25 | $7700.00 | Window Closed / Lapsed |