US4147767A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Albumin medicament carrier system
Assignee: 3M Co
•
Filing: 1977-09-30
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Granted: 1979-04-03
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Expires: 1997-09-30
Abstract
Abstract Solid serum albumin spherules having 5 to 30 percent by weight of an organic medicament homogeneously entrapped therein are disclosed. These spherules are especially suited for intravascular injection into the body wherein the drug is released from the spherule in a biphasic manner having an initial fast release phase followed by a slow release phase.
Inventors
- 👤 Anthony F. Yapel, Jr.
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 15:07
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/14; A61K9/16; A61K9/1605; A61K9/1629; A61K9/1658; A61P; A61P35/00; Y; Y10; Y10T; Y10T428/00; Y10T428/29; Y10T428/2982; Y10T428/2989
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
128 words
A therapeutic composition for controlling the release of drugs comprising solid spherules of serum albumin having homogeneously entrapped therein from 5 to 30 percent by weight of the spherule of an organic medicament which is at least 0.01 percent water soluble at 37° C., which spherules have been crosslinked by a process selected from the group consisting of: (a) heating at 110° to 180° C. for at least twenty minutes and (b) exposing to at least one chemical crosslinking agent which does not substantially affect the activity of said medicament for sufficient time to crosslink the albumin to a degree equivalent to heating at 110° to 180° C. for at least twenty minutes, and when placed in an aqueous medium, said medicament is released in a biphasic manner.
Claim 2
Dependent Claim
128 words
A therapeutic composition for controlling the release of drugs comprising solid spherules of serum albumin having homogeneously entrapped therein from 5 to 30 percent by weight of the spherule of an organic medicament which is at least 0.01 percent water soluble at 37° C., which spherules have been crosslinked by a process selected from the group consisting of: (a) heating at 110° to 180° C. for at least twenty minutes and (b) exposing to at least one chemical crosslinking agent which does not substantially affect the activity of said medicament for sufficient time to crosslink the albumin to a degree equivalent to heating at 110° to 180° C. for at least twenty minutes, and when placed in an aqueous medium, said medicament is released in a biphasic manner.
Claim 3
Dependent Claim
13 words
A composition according to claim 1 wherein the medicament is an antitumor agent.
Claim 4
Dependent Claim
11 words
A composition according to claim 2 wherein the medicament is 6-mercaptopurine.
Claim 5
Dependent Claim
11 words
A composition according to claim 2 wherein the medicament is 5-fluorouracil.
Claim 6
Dependent Claim
11 words
A composition according to claim 2 wherein the medicament is 6-thioguanine.
Claim 7
Dependent Claim
11 words
A composition according to claim 2 wherein the medicament is hydroxyurea.
Claim 8
Dependent Claim
11 words
A composition according to claim 2 wherein the medicament is colchicine.
Claim 9
Dependent Claim
11 words
A composition according to claim 2 wherein the medicament is chlorambucil.
Claim 10
Dependent Claim
11 words
A composition according to claim 2 wherein the medicament is busulfan.
Claim 11
Dependent Claim
12 words
A composition according to claim 1 wherein the medicament is a bronchodilator.
Claim 12
Dependent Claim
11 words
A composition according to claim 10 wherein the medicament is epinephrine.
Claim 13
Dependent Claim
11 words
A composition according to claim 10 wherein the medicament is salbutamol.
Claim 14
Dependent Claim
11 words
A composition according to claim 10 wherein the medicament is terbutaline.
Claim 15
Dependent Claim
16 words
A composition according to claim 1 dispersed in pharmaceutically acceptable extending medium suitable for intravascular injection.
Claim 16
Dependent Claim
21 words
A method of treating a disease state in an animal by intravascular injection of a therapeutic composition according to claim 1.
Claim 17
Dependent Claim
61 words
A process for preparing solid serum albumin spherules having a medicament homogeneously entrapped therein comprising injecting an aqueous solution of said albumin having said medicament dispersed therein into an agitated vegetable oil bath containing a lipophilic drying alcohol and a crosslinking agent which does not substantially affect the activity of said medicament selected from the group consisting of glutaraldehyde and formaldehyde.
Claim 18
Dependent Claim
61 words
A process for preparing solid serum albumin spherules having a medicament homogeneously entrapped therein comprising injecting an aqueous solution of said albumin having said medicament dispersed therein into an agitated vegetable oil bath containing a lipophilic drying alcohol and a crosslinking agent which does not substantially affect the activity of said medicament selected from the group consisting of glutaraldehyde and formaldehyde.
Claim 19
Dependent Claim
85 words
A therapeutic composition for controlling the release of drugs comprising solid spherules of serum albumin having homogeneously entrapped therein from 5 to 30 percent by weight of the spherule of an organic medicament which is at least 0.01 percent water soluble at 37° C., which spherules have been crosslinked by heating at 110° to 180° C. for at least twenty minutes during preparation to crosslink the albumin, and when placed in an aqueous medium, said medicament is released from said spherules in a biphasic manner.
Claim 20
Dependent Claim
85 words
A therapeutic composition for controlling the release of drugs comprising solid spherules of serum albumin having homogeneously entrapped therein from 5 to 30 percent by weight of the spherule of an organic medicament which is at least 0.01 percent water soluble at 37° C., which spherules have been crosslinked by heating at 110° to 180° C. for at least twenty minutes during preparation to crosslink the albumin, and when placed in an aqueous medium, said medicament is released from said spherules in a biphasic manner.
Claim 21
Dependent Claim
107 words
A therapeutic composition for controlling the release of drugs comprising solid spherules of serum albumin having homogeneously entrapped therein from 5 to 30 percent by weight of the spherule of an organic medicament which is at least 0.01 percent water soluble at 37° C., which spherules have been exposed to at least one chemical crosslinking agent which does not substantially affect the activity of the medicament to crosslink the albumin to a degree equivalent to that achieved by heating at 110° to 180° C. for at least twenty minutes, and when placed in an aqueous medium, said medicament is released from said spherules in a biphasic manner.
Claim 22
Dependent Claim
107 words
A therapeutic composition for controlling the release of drugs comprising solid spherules of serum albumin having homogeneously entrapped therein from 5 to 30 percent by weight of the spherule of an organic medicament which is at least 0.01 percent water soluble at 37° C., which spherules have been exposed to at least one chemical crosslinking agent which does not substantially affect the activity of the medicament to crosslink the albumin to a degree equivalent to that achieved by heating at 110° to 180° C. for at least twenty minutes, and when placed in an aqueous medium, said medicament is released from said spherules in a biphasic manner.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-04-02 | 1982-10-02 | 1983-04-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-04-02 | 1986-10-02 | 1987-04-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-04-02 | 1990-10-02 | 1991-04-03 | $7700.00 | Window Closed / Lapsed |