Patent US4960134A successfully refreshed from Google Patents.
US4133874A
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Lipid encapsulated hemoglobin cells
Assignee: University of Illinois Foundation
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Filing: 1978-02-10
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Granted: 1979-01-09
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Expires: 1998-02-10
Abstract
Abstract Synthetic erythrocytes. Hemoglobin is encapsulated in lipid materials to form cells which are typically 0.1 to 10 microns in their greatest dimension. Preferably cholesterol and one or more phospholipids are included in the cell membrane. The lipid membrane is of such character and thinness that O2-CO2 transfer thereacross is readily accomplished. The preferred encapsulation process utilizes ultrasonic energy.
Inventors
- 👤 Irving F. Miller
- 👤 Ljubomir Djordjevich
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 18:17
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/10; A61K9/127; A61K38/00; A61K38/16; A61K38/41; A61K38/42; Y; Y10; Y10T; Y10T428/00; Y10T428/29; Y10T428/2982; Y10T428/2984
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
34 words
A synthetic cell for use in oxygen and carbon dioxide transport as an in vivo substitute for naturally-ocurring erythrocytes, said cell comprising a synthetic cell membrane of lipid material having stromafree hemoglobin encapsulated therein.
Claim 2
Dependent Claim
34 words
A synthetic cell for use in oxygen and carbon dioxide transport as an in vivo substitute for naturally-ocurring erythrocytes, said cell comprising a synthetic cell membrane of lipid material having stromafree hemoglobin encapsulated therein.
Claim 3
Dependent Claim
12 words
The cell of claim 1 wherein said lipid material includes a sterol.
Claim 4
Dependent Claim
12 words
The cell of claim 1 wherein said lipid material includes a phospholipid.
Claim 5
Dependent Claim
31 words
The cell of claim 3 wherein said phospholipid is selected from the group consisting of lecithin, cephalin, sphingomyelin, phosphatidic acid, phosphatidyl serine, phosphatidyl inositol, phosphatidyl choline, phosphatidyl ethanolamine, and mixtures thereof.
Claim 6
Dependent Claim
23 words
The cell of claim 3 wherein said cell is substantially spherical and has a diameter of from about 0.1 to about 10 microns.
Claim 7
Dependent Claim
38 words
The cell of claim 1 wherein said lipid material includes, in combination, cholesterol, lecithin and phosphatidic acid in a ratio of approximately one part by weight cholesterol to two parts by weight of combined lecithin and phosphatidic acid.
Claim 8
Dependent Claim
38 words
The cell of claim 1 wherein said lipid material includes, in combination, cholesterol, lecithin and phosphatidic acid in a ratio of approximately one part by weight cholesterol to three parts by weight of combined lecithin and phosphatidic acid.
Claim 9
Dependent Claim
26 words
A composition comprising the cell of claim 1 in combination with a liquid carrier physiologically compatible with a host animal to whom the composition is administered.
Claim 10
Dependent Claim
21 words
The composition of claim 8 wherein said liquid carrier is selected from the group consisting of normal saline and Krebs-Ringers solutions.
Claim 11
Dependent Claim
25 words
The composition of claim 8 wherein said liquid carrier is a synthetic plasma selected from the group consisting of dextran, hydroxyethyl starch and albumin solutions.
References Cited (Backward Citations)
DE2236909A1
Cited
US3887698A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-01-08 | 1982-07-10 | 1983-01-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-01-08 | 1986-07-10 | 1987-01-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-01-08 | 1990-07-10 | 1991-01-09 | $7700.00 | Window Closed / Lapsed |