US4308166A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Process for the extemporaneous preparation of liposomes
Assignee: Merck Serono SpA
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Filing: 1979-10-30
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Granted: 1981-12-29
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Expires: 1999-10-30
Abstract
Abstract The extemperaneous preparation of liposomes incorporating englobed therapeutically active substances is effected by introducing an aspirated phopholipid emulsion into a container containing the active substance as a dry powder or lyophilate.
Inventors
- 👤 Enzo Marchetti
- 👤 Umberto Bucciarelli
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 14:15
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/10; A61K9/127; A61K9/1277; Y; Y10; Y10T; Y10T428/00; Y10T428/29; Y10T428/2982; Y10T428/2984
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
40 words
A process for the extemporaneous preparation of liposomes incorporating englobulated therapeutically active substances characterized in that an aspirated phospholipid emulsion in water or physiologic solution is introduced into a container containing the active substance as a dry powder or lyophilate.
Claim 2
Dependent Claim
40 words
A process for the extemporaneous preparation of liposomes incorporating englobulated therapeutically active substances characterized in that an aspirated phospholipid emulsion in water or physiologic solution is introduced into a container containing the active substance as a dry powder or lyophilate.
Claim 3
Dependent Claim
27 words
A process according to claim 1 characterized in that as a phospholipid emulsion there is used a phospholipid emulsion prepared from the yolk of a hen's egg.
Claim 4
Dependent Claim
25 words
A process according to claim 1 for the preparation of liposomes incorporating therapeutically active substances characterized in that the active substance is an adrenocortical extract.
Claim 5
Dependent Claim
24 words
A process according to claim 1 characterized in that the emulsion, after introduction to the container, is agitated, aspirated and introduced into a container.
Claim 6
Dependent Claim
19 words
A process according to claim 4 characterized in that the aspiration and introduction steps are effected with a syringe.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-12-28 | 1985-06-29 | 1985-12-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-12-28 | 1989-06-29 | 1989-12-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-12-28 | 1993-06-29 | 1993-12-29 | $7700.00 | Window Closed / Lapsed |