US3993754A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Liposome-encapsulated actinomycin for cancer chemotherapy
Assignee: Energy Research and Development Administration ERDA
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Filing: 1974-10-09
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Granted: 1976-11-23
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Expires: 1994-10-09
Abstract
Abstract An improved method is provided for chemotherapy of malignant tumors by injection of antitumor drugs. The antitumor drug is encapsulated within liposomes and the liposomes containing the encapsulated drug are injected into the body. The encapsulated drug penetrates into the tumor cells where the drug is slowly released and induces degeneration and death of the tumor cells, while any toxicity to the host body is reduced. Liposome encapsulation of actinomycin D has been found to be particularly effective in treating cancerous abdominal tumors, while drastically reducing the toxicity of actinomycin D to the host.
Inventors
- 👤 Yueh-Erh Rahman
- 👤 Elizabeth A. Cerny
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:18
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/04; A61K9/00; A61K9/10; A61K9/127
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
37 words
A method of reducing the toxicity of actinomycin D when employed as an antineoplastic agent in an animal or man which comprises administering to said animal or man an effective antineoplastic amount of liposome encapsulated actinomycin D.
Claim 2
Independent Claim
37 words
A method of reducing the toxicity of actinomycin D when employed as an antineoplastic agent in an animal or man which comprises administering to said animal or man an effective antineoplastic amount of liposome encapsulated actinomycin D.
Claim 3
Dependent Claim
21 words
The method of claim 1 wherein said liposome encapsulated actinomycin D is contained within aqueous solution layers entrapped between lipid bilayers.
Claim 4
Dependent Claim
62 words
The method in accordance with claim 1 wherein said actinomycin D is encapsulated within liposomes by: dissolving a mixture of lecithin and cholesterol in chloroform; dissolving the actinomycin D in CaC1 2 solution; forming a dried film of the lecithin-cholesterol mixture; and adding the actinomycin D-CaCl 2 solution to the dried film so as to form the liposomes encapsulating the actinomycin D.
Claim 5
Dependent Claim
18 words
The method of claim 1 wherein said liposome encapsulated actinomycin D is administered by intravenous or intraperitoneal injection.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-11-23 | 1980-05-24 | 1980-11-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-11-23 | 1984-05-24 | 1984-11-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-11-23 | 1988-05-24 | 1988-11-23 | $7700.00 | Window Closed / Lapsed |