Patent US7736219B2 successfully refreshed from Google Patents.
US6579256B2
Expired / Lapsed
US
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Instrument for subretinal implantation
Assignee: Photogenesis Inc
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Filing: 1999-10-04
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Granted: 2003-06-17
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Expires: 2019-10-04
Abstract
Abstract An instrument for subretinal implantation comprising an elongate tube having a distal end and a proximal end, the tube having a lumen passing from the proximal end to the distal end, the distal end having a distal tip, wherein the lumen forms an opening in the tip, the instrument further including a plunger, the plunger being capable of sliding motion within and with respect to the tube, wherein the outer diameter of the distal end of the elongate tube is sufficiently small to be inserted through the pars plana area of an eye and the length of the distal end of the elongate tube is sufficient long to permit the opening in said tip to thereafter be inserted beneath the retina through an opening therein, wherein the plunger can express material within the lumen therefrom through the opening in the tip into the subretinal space of an eye into which the tip is inserted.
Inventors
- 👤 Stephen E. Hughes
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 20:50
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/3683; A61B; A61B90/00; A61F; A61F2/00; A61F2/02; A61F2/14; A61F9/00; A61F9/0008; A61F9/0017; A61F9/007; A61K; A61K35/00; A61K35/12; A61K35/44; A61L27/3604; A61L27/3641; A61L27/38; A61L27/3804; A61L27/3813; A61L27/383; A61L27/3839; A61L27/3886; A61L27/3891; A61B17/00; A61B2017/00969; A61L2430/00; A61L2430/16; A61M; A61M25/00; A61M25/0021; A61M2025/0042
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
253 words
An instrument for subretinal implantation of a solid or semi-solid implant into a mammalian eye, comprising: an elongate tube having a distal end and a proximal end, said tube having a lumen passing from said proximal end to said distal end, said distal end having a distal tip end of a curved shape, wherein at least a portion of said tip end has a width greater than its height, said tube having dimensions that permit subretinal implantation of a solid or semi-solid implant, wherein said lumen forms an opening in said tip end, said instrument further comprising a plunger at least partially disposed within said tube, said plunger and said tube being capable of relative sliding motion with respect to each other, wherein said distal end of said elongate tube has a diameter sufficiently small to be inserted through the pars plana area of an eye and said distal end of said elongate tube has a length sufficient to permit said opening in said tip to be inserted beneath the retina through an opening therein while said plunger extends at least to said opening in said retina and said proximal end is exterior of the eye, wherein sliding motion of said tube relative to said plunger can express material within said lumen from said lumen through said opening in said tip into the subretinal space of an eye into which said tip is inserted, wherein said instrument is for implanting into the subretinal space of a host eye a solid or semi-solid implant.
Claim 2
Dependent Claim
253 words
An instrument for subretinal implantation of a solid or semi-solid implant into a mammalian eye, comprising: an elongate tube having a distal end and a proximal end, said tube having a lumen passing from said proximal end to said distal end, said distal end having a distal tip end of a curved shape, wherein at least a portion of said tip end has a width greater than its height, said tube having dimensions that permit subretinal implantation of a solid or semi-solid implant, wherein said lumen forms an opening in said tip end, said instrument further comprising a plunger at least partially disposed within said tube, said plunger and said tube being capable of relative sliding motion with respect to each other, wherein said distal end of said elongate tube has a diameter sufficiently small to be inserted through the pars plana area of an eye and said distal end of said elongate tube has a length sufficient to permit said opening in said tip to be inserted beneath the retina through an opening therein while said plunger extends at least to said opening in said retina and said proximal end is exterior of the eye, wherein sliding motion of said tube relative to said plunger can express material within said lumen from said lumen through said opening in said tip into the subretinal space of an eye into which said tip is inserted, wherein said instrument is for implanting into the subretinal space of a host eye a solid or semi-solid implant.
Claim 3
Dependent Claim
43 words
The instrument of claim 1 , wherein expression of an implant contained within said instrument from said opening in said tip when inserted beneath a retina through an opening in the retina is achieved by retracting said tube with respect to said plunger.
Claim 4
Dependent Claim
27 words
The instrument of claim 1 , wherein said tube can move linearly with respect to said plunger when said plunger is held in a fixed linear position.
Claim 5
Dependent Claim
33 words
The instrument of claim 3 , wherein at least said distal end of said elongate tube has an interior width of about 2.5 mm and an interior height of about about 0.5 mm.
Claim 6
Dependent Claim
24 words
The instrument of claim 1 , wherein at least said distal end of said tube has a width of at least about 2.5 mm.
Claim 7
Dependent Claim
36 words
The instrument of claim 1 , wherein at least said distal end of said elongate tube has a width of at least about 2 . 5 mm and a height of at least about 0.5 mm.
Claim 8
Dependent Claim
25 words
The instrument of claim 1 , wherein said distal end is curved along its longitudinal axis to facilitate insertion beneath the retina of an eye.
Claim 9
Dependent Claim
120 words
A combination comprising an instrument such as that recited in claim 1 , and a subretinal implant, wherein said implant can be placed in said distal end of said lumen and is capable of implantation beneath the retina of an eye via insertion of said distal end of said tube into the eye, insertion of said tip beneath the retina, and expression of said implant from said opening in said tip beneath the retina, wherein said implant comprises at least one of the group consisting of a solid or semi-solid carrier, a pharmacologic agent, and a layer of retinal cells from a donor eye in which the cells have the same cell to cell organization as in the donor eye.
Claim 10
Dependent Claim
16 words
The combination of claim 2 , wherein said implant comprises a carrier and a pharmacologic agent.
Claim 11
Dependent Claim
11 words
The combination of claim 2 , wherein said implant is flexible.
Claim 12
Dependent Claim
11 words
The combination of claim 2 , wherein said carrier comprises gelatin.
Claim 13
Dependent Claim
36 words
The combination of claim 2 , wherein said implant comprises a layer of retinal cells from a donor eye, said cells in said layer having the same cell to cell organization as in the donor eye.
Claim 14
Dependent Claim
19 words
The combination of claim 2 , wherein said implant comprises a layer of photoreceptor cells from a donor eye.
Claim 15
Dependent Claim
16 words
The combination of claim 2 , wherein said implant comprises a confluent population of retinal cells.
Claim 16
Dependent Claim
23 words
The combination of claim 2 , wherein at least a portion of said implant dissolves or degrades upon implantation into a host eye.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2006-06-16 | 2006-12-16 | 2007-06-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2010-06-16 | 2010-12-16 | 2011-06-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2014-06-16 | 2014-12-16 | 2015-06-17 | $7700.00 | Window Closed / Lapsed |