Patent US2373358A successfully refreshed from Google Patents.
US4774091A
Expired / Lapsed
US
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Long-term sustained-release preparation
Assignee: Sumitomo Pharma Co Ltd
•
Filing: 1986-03-31
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Granted: 1988-09-27
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Expires: 2006-03-31
Abstract
Abstract A solid sustained-release preparation in the form of a needle-like or bar-like shape, which consists essentially of an active ingredient and a pharmaceutically acceptable biodegradable carrier (e.g. proteins, preferably collagen, gelatin, and a mixture thereof). The sustained-release preparation can be administered to the body or implanted into the body by injection or an injection-like method and can release the active ingredient at an effective level for a long period of time when administered.
Inventors
- 👤 Yoshiya Yamahira
- 👤 Keiji Fujioka
- 👤 Shiegeji Sato
- 👤 Yoshihiro Takada
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:11
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0024; A61K31/00; A61K31/33; A61K31/395; A61K31/40; A61K31/403; A61K31/404; A61K31/405; A61K31/41; A61K31/415; A61K38/00; A61K38/16; A61K38/17; A61K38/19; A61K38/21; A61K38/212; A61K9/20; A61K9/2004; A61K9/2022; A61K9/2063
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
68 words
A method for the preparation of a solid sustained-release preparation, which comprises mixing under aqueous conditions a physiologically active ingredient that is unstable to heat and a pharmaceutically acceptable biodegradable protein carrier to incorporate the active ingredient in a carrier matrix to a degree sufficient to provide sustained-release properties; drying the resulting mixture; and then forming the dried material into the form of a needle-like or bar-like shape.
Claim 2
Independent Claim
68 words
A method for the preparation of a solid sustained-release preparation, which comprises mixing under aqueous conditions a physiologically active ingredient that is unstable to heat and a pharmaceutically acceptable biodegradable protein carrier to incorporate the active ingredient in a carrier matrix to a degree sufficient to provide sustained-release properties; drying the resulting mixture; and then forming the dried material into the form of a needle-like or bar-like shape.
Claim 3
Dependent Claim
15 words
The method according to claim 1, wherein said biodegradable carrier is collagen, atelocollagen or gelatin.
Claim 4
Dependent Claim
12 words
The method according to claim 2, wherein said biodegradable carrier is collagen.
Claim 5
Dependent Claim
33 words
The method according to claim 1, wherein said active ingredient is a member selected from the group consisting of tissue plasminogen activator, prostaglandins, prostacyclines, bio-hormones, interferons, interleukins, tumor necrosis factor and other cytokines.
Claim 6
Dependent Claim
42 words
The method according to claim 1, wherein said active ingredient is a member selected from the group consisting of interferons, interleukins, tumor necrosis factor, growth hormone, growth hormone releasing factor, somatomedines, calcitonin, macrophage activating factor, migration inhibitory factor, and colony stimulating factor.
Claim 7
Dependent Claim
20 words
The method according to claim 1, wherein said mixing is conducted at a temperature of from 5° to 30° C.
Claim 8
Dependent Claim
20 words
The method according to claim 1, wherein said drying is conducted at a temperature of from 15° to 30° C.
Claim 9
Dependent Claim
20 words
The method according to claim 6, wherein said drying is conducted at a temperature of from 15° to 30° C.
Claim 10
Dependent Claim
23 words
The method according to claim 1, wherein said drying is performed by lyophilization at a temperature of from -50° C. to 0° C.
Claim 11
Dependent Claim
28 words
The method according to claim 9, wherein the product obtained from said lyophilization is subjected to pulverization at a temperature of from -100° C. to about room temperature.
Claim 12
Dependent Claim
12 words
The method according to claim 4, wherein said biodegradable carrier is collagen.
Claim 13
Dependent Claim
12 words
The method according to claim 5, wherein said biodegradable carrier is collagen.
Claim 14
Dependent Claim
12 words
The method according to claim 6, wherein said biodegradable carrier is collagen.
Claim 15
Dependent Claim
12 words
The method according to claim 7, wherein said biodegradable carrier is collagen.
Claim 16
Dependent Claim
12 words
The method according to claim 8, wherein said biodegradable carrier is collagen.
Claim 17
Dependent Claim
19 words
The method according to claim 1, wherein said sustained-release preparation is prepared without the use of any binding agent.
Claim 18
Dependent Claim
19 words
The method according to claim 3, wherein said sustained-release preparation is prepared without the use of any binding agent.
Claim 19
Dependent Claim
19 words
The method according to claim 8, wherein said sustained-release preparation is prepared without the use of any binding agent.
Claim 20
Dependent Claim
19 words
The method according to claim 10, wherein said sustained-release preparation is prepared without the use of any binding agent.
Claim 21
Dependent Claim
19 words
The method according to claim 14, wherein said sustained-release preparation is prepared without the use of any binding agent.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-09-27 | 1992-03-28 | 1992-09-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-09-27 | 1996-03-28 | 1996-09-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-09-27 | 2000-03-28 | 2000-09-27 | $7700.00 | Window Closed / Lapsed |