US5658882A
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US
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Methods of inducting formation of tendon and/or ligament tissue comprising administering BMP-12, BMP-13, and/or MP-52
Assignee: Genetics Institute LLC
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Filing: 1994-12-22
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Granted: 1997-08-19
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Expires: 2014-12-22
Abstract
Abstract The present invention relates to methods for the induction of tendon/ligament-like tissue formation, wound healing and ligament and other tissue repair, using a composition comprising BMP-12, BMP-13 or MP-52, or combinations of the above.
Inventors
- 👤 Anthony J. Celeste
- 👤 John M. Wozney
- 👤 Vicki A. Rosen
- 👤 Neil M. Wolfman
- 👤 Gerald H. Thomsen
- 👤 Douglas A. Melton
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 05:05
CPC Classifications
C; C12; C12N; C12N15/00; C12N15/09; C12N15/11; C07; C07K; C07K14/00; C07K14/435; C07K14/475; C07K14/51; A; A61; A61K; A61K38/00; A61K38/16; A61K38/17; A61K38/18; A61K38/1875; A61L; A61L27/00; A61L27/14; A61L27/22; A61L27/227; A61L27/36; A61L27/38; A61L27/3839; A61L27/3843; A61L27/386; A61L27/50; A61L27/54; A61P; A61P1/00; A61P1/02; A61P17/00; A61P17/02; A61P19/00; A61P19/02; A61P19/04; A61P19/08; A61P43/00; A61P5/00; C07K2319/00; C07K2319/01; C07K2319/02
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
37 words
A method of inducing formation of tendon and/or ligament tissue comprising administering to a patient a composition comprising at least one protein selected from the group consisting of Bone Morphogenic Protein (BMP)-12, BMP-13 and Morphogenic Protein (MP)-52.
Claim 2
Independent Claim
37 words
A method of inducing formation of tendon and/or ligament tissue comprising administering to a patient a composition comprising at least one protein selected from the group consisting of Bone Morphogenic Protein (BMP)-12, BMP-13 and Morphogenic Protein (MP)-52.
Claim 3
Dependent Claim
11 words
A method according to claim 1, wherein the composition comprises BMP-12.
Claim 4
Dependent Claim
11 words
A method according to claim 1, wherein the composition comprises BMP-13.
Claim 5
Dependent Claim
11 words
A method according to claim 1, wherein the composition comprises MP-52.
Claim 6
Dependent Claim
67 words
A method according to claim 1, wherein the composition comprises at least one protein characterized by an amino acid sequence selected from the group consisting of: a) amino acids #-25, #1 or #3 to #104 of SE ID NO: 2; b) amino acids #1 or #19 to #120 of SE ID NO: 4; and c) amino acids #1 or #19 to #120 of SE ID NO: 26.
Claim 7
Dependent Claim
55 words
A method according to claim 5, wherein the amino acid sequence of the protein is selected from the group consisting of: a) amino acids #-25 to #104 of SE ID NO: 2; b) amino acids #1 to #104 of SE ID NO: 2; and c) amino acids #3 to #104 of SE ID NO: 2.
Claim 8
Dependent Claim
44 words
A method according to claim 5, wherein the amino acid sequence of the protein is selected from the group consisting of: a) amino acids #1 to #120 of SE ID NO: 4; and b) amino acids #19 to #120 of SE ID NO: 4.
Claim 9
Dependent Claim
44 words
A method according to claim 5, wherein the amino acid sequence of the protein is selected from the group consisting of: a) amino acids #1 to #120 of SE ID NO: 26; and b) amino acids #19 to #120 of SE ID NO: 26.
Claim 10
Dependent Claim
14 words
A method according to claim 5, wherein the composition further comprises a suitable carrier.
Claim 11
Dependent Claim
29 words
A method according to claim 7, wherein the composition comprises a protein characterized by the amino acid sequence from amino acids #-25 to #104 of SE ID NO: 2.
Claim 12
Dependent Claim
29 words
A method according to claim 9, wherein the composition comprises a protein characterized by the amino acid sequence from amino acids #1 to #104 of SE ID NO: 2.
Claim 13
Dependent Claim
29 words
A method according to claim 9, wherein the composition comprises a protein characterized by the amino acid sequence from amino acids #3 to #104 of SE ID NO: 2.
Claim 14
Dependent Claim
29 words
A method according to claim 9, wherein the composition comprises a protein characterized by the amino acid sequence from amino acids #1 to #120 of SE ID NO: 4.
Claim 15
Dependent Claim
29 words
A method according to claim 9, wherein the composition comprises a protein characterized by the amino acid sequence from amino acids #19 to #120 of SE ID NO: 4.
Claim 16
Dependent Claim
27 words
A method according to claim 9, wherein the composition comprises a protein characterized by the amino acid sequence from #1 to #120 of SE ID NO: 26.
Claim 17
Dependent Claim
27 words
A method according to claim 9, wherein the composition comprises a protein characterized by the amino acid sequence from #19 to #120 of SE ID NO: 26.
Claim 18
Independent Claim
36 words
A method of stimulating the growth of tendon- or ligament-forming cells comprising administering to such cells a composition comprising at least one protein selected from the group consisting of Bone Morphogenetic Protein (BMP)-12, BMP-13 and MP-52.
Claim 19
Independent Claim
36 words
A method of stimulating the growth of tendon- or ligament-forming cells comprising administering to such cells a composition comprising at least one protein selected from the group consisting of Bone Morphogenetic Protein (BMP)-12, BMP-13 and MP-52.
Claim 20
Dependent Claim
11 words
A method according to claim 17, wherein the composition comprises BMP-12.
Claim 21
Dependent Claim
11 words
A method according to claim 17, wherein the composition comprises BMP-13.
Claim 22
Dependent Claim
11 words
A method according to claim 17, wherein the composition comprises MP-52.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 2000-08-18 | 2001-02-17 | 2001-08-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2004-08-18 | 2005-02-17 | 2005-08-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2008-08-18 | 2009-02-17 | 2009-08-19 | $7700.00 | Window Closed / Lapsed |