US5108922A
Expired / Lapsed
US
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DNA sequences encoding BMP-1 products
Assignee: Genetics Institute LLC
•
Filing: 1990-07-31
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Granted: 1992-04-28
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Expires: 2010-07-31
Abstract
Abstract Purified BMP-1 proteins and processes for producing them are disclosed. They may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair.
Inventors
- 👤 Elizabeth A. Wang
- 👤 John M. Wozney
- 👤 Vicki Rosen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 14:21
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/475; C07K14/51; A; A61; A61L; A61L24/00; A61L24/04; A61L24/043; A61L27/00; A61L27/14; A61L27/22; A61L27/227; A61K; A61K38/00
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
6 words
An isolated encoding a BMP-1 protein.
Claim 2
Dependent Claim
6 words
An isolated encoding a BMP-1 protein.
Claim 3
Dependent Claim
10 words
A host cell transformed with a DNA of claim 1.
Claim 4
Dependent Claim
76 words
An isolated DNA encoding a BMP-1 protein which is characterized by the ability to induce the formation of bone and/or cartilage said DNA comprising a coding sequence selected from the group consisting of: (a) nucleotide #294 through nucleotide #404 of FIG. 1; (b) nucleotide #3440 through nucleotide #3550 of FIG. 2; (c) nucleotide #36 through nucleotide #2225 of FIG. 3; and (d) naturally occurring allelic sequences and equivalent degenerative codon sequences of (a), (b), and (c).
Claim 5
Dependent Claim
76 words
An isolated DNA encoding a BMP-1 protein which is characterized by the ability to induce the formation of bone and/or cartilage said DNA comprising a coding sequence selected from the group consisting of: (a) nucleotide #294 through nucleotide #404 of FIG. 1; (b) nucleotide #3440 through nucleotide #3550 of FIG. 2; (c) nucleotide #36 through nucleotide #2225 of FIG. 3; and (d) naturally occurring allelic sequences and equivalent degenerative codon sequences of (a), (b), and (c).
Claim 6
Dependent Claim
17 words
A vector comprising a DNA of claim 3 in operative association with an expression control sequence therfor.
Claim 7
Dependent Claim
10 words
A host cell transformed with a vector of claim 4.
Claim 8
Dependent Claim
18 words
An isolated DNA encoding a BMP-1 protein said DNA comprising nucleotide #36 through nucleotide #2225 of FIG. 3.
Claim 9
Dependent Claim
18 words
An isolated DNA encoding a BMP-1 protein said DNA comprising nucleotide #36 through nucleotide #2225 of FIG. 3.
Claim 10
Dependent Claim
8 words
A vector comprising the DNA of claim 6.
Claim 11
Dependent Claim
9 words
A host cell transformed with vector of claim 7.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-04-28 | 1995-10-28 | 1996-04-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-04-28 | 1999-10-28 | 2000-04-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-04-28 | 2003-10-28 | 2004-04-28 | $7700.00 | Window Closed / Lapsed |