US4795804A
Expired / Lapsed
US
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Bone morphogenetic agents
Assignee: University of California
•
Filing: 1985-08-07
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Granted: 1989-01-03
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Expires: 2005-08-07
Abstract
Abstract The production and isolation of bone morphogenetic peptide agents displaying the osteoinductive and immunoreactive activity of bone morphogenetic protein (BMP) and deriving from natural, synthetic or recombinant DNA sources, and said agents.
Inventors
- 👤 Marshall R. Urist
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:19
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/475; C07K14/51; A; A61; A61P; A61P43/00; A61K; A61K38/00; Y; Y10; Y10S; Y10S530/00; Y10S530/827; Y10S530/84
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
57 words
A bone morphogenetic peptide having an amino acid sequence, said sequence selected from the group consisting of amino acid sequences of peptide fragments (BMP-p) having a relative molecular weight (M r ) of about 4K to about 7K and derived from proteolysis of bone morphogenetic protein (BMP), said peptide fragments being osteoinductive and immunoreactive with anti-BMP antibody.
Claim 2
Dependent Claim
57 words
A bone morphogenetic peptide having an amino acid sequence, said sequence selected from the group consisting of amino acid sequences of peptide fragments (BMP-p) having a relative molecular weight (M r ) of about 4K to about 7K and derived from proteolysis of bone morphogenetic protein (BMP), said peptide fragments being osteoinductive and immunoreactive with anti-BMP antibody.
Claim 3
Dependent Claim
13 words
A bone morphogenetic peptide of claim 1, wherein the BMP is human BMP.
Claim 4
Dependent Claim
18 words
A bone morphogenetic peptide of claim 2, wherein the relative molecular weight (M r ) is about 4.7K±0.3K.
Claim 5
Dependent Claim
50 words
A bone morphogenetic peptide of claims 1, 2 or 3 wherein the amino acid sequence contains the following amino acid sequence: -ILE - PRO - GLN - GLN - ARG - ARG - TRP - ARG - ALA - LYS - VAL - GLN - ASN - ARG - ILE-.
Claim 6
Dependent Claim
35 words
A bone morphogenentic peptide of claim 4, further including the following amino acid sequence: -ARG - ASP - SER - TYR - LYS - PRO - VAL - HIS - GLU - LEU - ASN-.
Claim 7
Dependent Claim
31 words
A bone morphogenetic peptide of claim 5, further including the following amino acid sequence: -ARG - CYS - ALA - ASP - GLY - TYR - ARG - LEU - CYS-.
Claim 8
Dependent Claim
13 words
A bone morphogenetic peptide of claim 1, wherein the BMP is bovine BMP.
Claim 9
Dependent Claim
18 words
A bone morphogenetic peptide of claim 7, wherein the relative molecular weight (M r ) is about 4.1K.
Claim 10
Dependent Claim
18 words
A bone morphogenetic peptide of claim 1, 2 or 3, wherein the limited proteolysis is pepsin limited proteolysis.
Claim 11
Dependent Claim
15 words
A bone morphogenetic peptide of claim 4, wherein the limited proteolysis is pepsin limited proteolysis.
Claim 12
Dependent Claim
18 words
A bone morphogenetic peptide of claim 1, 2 or 7, wherein the limited proteolysis is trypsin limited proteolysis.
Claim 13
Dependent Claim
27 words
A composition for inducing bone formation comprising a bone morphogenetic peptide selected from the group of bone morphogenetic peptides of claims 1, 2, 3, 7 or 8.
Claim 14
Dependent Claim
22 words
A composition for inducing bone formation comprising a bone morphogenetic peptide selected from the group of bone morphogenetic peptides of claim 4.
Claim 15
Dependent Claim
22 words
A composition for inducing bone formation comprising a bone morphogenetic peptide selected from the group of bone morphogenetic peptides of claims 9.
Claim 16
Dependent Claim
22 words
A composition for inducing bone formation comprising a bone morphogenetic peptide selected from the group of bone morphogenetic peptides of claims 10.
Claim 17
Dependent Claim
22 words
A composition for inducing bone formation comprising a bone morphogenetic peptide selected from the group of bone morphogenetic peptides of claims 11.
Claim 18
Dependent Claim
29 words
A method for inducing bone formation in vertebrates which comprises administering to said vertebrate in a pharmaceutically acceptable manner an effective amount of a composition according to claim 12.
Claim 19
Dependent Claim
29 words
A method for inducing bone formation in vertebrates which comprises adminstering to said vertebrate in a pharmaceutically acceptable manner an effective amount of a composition according to claim 13.
Claim 20
Dependent Claim
29 words
A method for inducing bone formation in vertebrates which comprises administering to said vertebrate in a pharmaceutically acceptable manner an effective amount of a composition according to claim 14.
Claim 21
Dependent Claim
29 words
A method for inducing bone formation in vertebrates which comprises administering to said vertebrate in a pharmaceutically acceptable manner an effective amount of a composition according to claim 15.
Claim 22
Dependent Claim
29 words
A method for inducing bone formation in vertebraes which comprises administering to said vertebrate in a pharamceutically acceptable manner an effective amount of a composition according to claim 16.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-01-03 | 1992-07-04 | 1993-01-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-01-03 | 1996-07-04 | 1997-01-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-01-03 | 2000-07-04 | 2001-01-03 | $7700.00 | Window Closed / Lapsed |