US5580465A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method for preparing platelets
Assignee: Haemonetics Puerto Rico LLC
•
Filing: 1993-12-03
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Granted: 1996-12-03
•
Expires: 2013-12-03
Abstract
Abstract A method for preparing platelets comprises the steps of obtaining whole blood from human, preparing platelet rich plasma from the whole blood and then passing the platelet rich plasma through a filter comprising a porous medium having a CWST of at least about 70 dynes/cm, under conditions sufficient to remove in excess of about 99.99% of the leucocytes from the platelet rich plasma, with preparing platelet rich plasma and passing the platelet rich plasma through the filter occurring in an integrally-attached blood bag system within a few hours of obtaining whole blood from human.
Inventors
- 👤 David B. Pall
- 👤 Thomas C. Gsell
- 👤 Brian T. Muellers
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 01:08
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/02; A61M1/0209; A61M1/0218; A61M1/36; A61M1/3621; A61M1/3627; A61M1/3633; B; B01; B01D; B01D39/00; B01D39/14; B01D39/16; B01D39/1607; B01D39/1623; A61M2202/00; A61M2202/04; A61M2202/0413; A61M2202/0427; A61M2202/0429; A61M2202/0439
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
92 words
A method for preparing platelets comprising: obtaining whole blood from a human; preparing platelet rich plasma from the whole blood; then passing the platelet rich plasma through a filter comprising a porous medium having a CWST of at least about 70 dynes/cm, under conditions sufficient to remove in excess of about 99.99% of the leucocytes from the platelet rich plasma, with preparing platelet rich plasma and passing the platelet rich plasma through the filter occurring in an integrally-attached blood bag system within a few hours of obtaining whole blood from a human.
Claim 2
Independent Claim
92 words
A method for preparing platelets comprising: obtaining whole blood from a human; preparing platelet rich plasma from the whole blood; then passing the platelet rich plasma through a filter comprising a porous medium having a CWST of at least about 70 dynes/cm, under conditions sufficient to remove in excess of about 99.99% of the leucocytes from the platelet rich plasma, with preparing platelet rich plasma and passing the platelet rich plasma through the filter occurring in an integrally-attached blood bag system within a few hours of obtaining whole blood from a human.
Claim 3
Dependent Claim
23 words
The method of claim 1 wherein passing the platelet-rich plasma through the filter comprises passing the platelet-rich plasma through a fibrous porous medium.
Claim 4
Dependent Claim
17 words
The method of claim 1 further comprising separating the leukocyte-depleted platelet-rich plasma into platelet concentrate and plasma.
Claim 5
Dependent Claim
23 words
The method of claim 1 wherein the leukocytes are removed from the platelet-rich plasma within 8 hours of obtaining the human whole blood.
Claim 6
Dependent Claim
21 words
The method of claim 1 wherein the filter has a voids volume in the range from about 71% to about 83%.
Claim 7
Dependent Claim
21 words
The method of claim 5 wherein the filter has a voids volume in the range from about 75% to about 80%.
Claim 8
Independent Claim
94 words
A method for preparing platelets comprising: obtaining whole blood from a human; preparing platelet rich plasma from the whole blood; then passing the platelet rich plasma through a filter comprising a porous medium having a negative zeta potential at a pH of 7.3, under conditions sufficient to remove in excess of about 99.99% of the leucocytes from the platelet rich plasma, with preparing platelet rich plasma and passing the platelet rich plasma it through the filter occurring in an integrally-attached blood bag system within a few hours of obtaining whole blood from a human.
Claim 9
Independent Claim
94 words
A method for preparing platelets comprising: obtaining whole blood from a human; preparing platelet rich plasma from the whole blood; then passing the platelet rich plasma through a filter comprising a porous medium having a negative zeta potential at a pH of 7.3, under conditions sufficient to remove in excess of about 99.99% of the leucocytes from the platelet rich plasma, with preparing platelet rich plasma and passing the platelet rich plasma it through the filter occurring in an integrally-attached blood bag system within a few hours of obtaining whole blood from a human.
Claim 10
Dependent Claim
28 words
The method of claim 7 wherein the filter has a negative zeta potential in the range of about -3 to about -30 millivolts at a pH of 7.3.
Claim 11
Independent Claim
96 words
A method for preparing platelets comprising: obtaining whole blood from a human; preparing platelet rich plasma from the whole blood; then passing the platelet rich plasma through a filter comprising a porous medium having a voids volume in the range of about 50% to about 89%, under conditions sufficient to remove in excess of about 99.99% of the leucocytes from the platelet rich plasma, with preparing platelet rich plasma and passing the platelet rich plasma through the filter occurring in an integrally-attached blood bag system within a few hours of obtaining whole blood from a human.
Claim 12
Independent Claim
96 words
A method for preparing platelets comprising: obtaining whole blood from a human; preparing platelet rich plasma from the whole blood; then passing the platelet rich plasma through a filter comprising a porous medium having a voids volume in the range of about 50% to about 89%, under conditions sufficient to remove in excess of about 99.99% of the leucocytes from the platelet rich plasma, with preparing platelet rich plasma and passing the platelet rich plasma through the filter occurring in an integrally-attached blood bag system within a few hours of obtaining whole blood from a human.
Claim 13
Dependent Claim
36 words
The method of claim 9 wherein passing the platelet-rich plasma through the filter comprises passing the plasma through a filter including fibers having a fiber diameter in the range of about 1.0 to about 4 microns.
Claim 14
Dependent Claim
21 words
The method of claim 9 wherein the filter has a voids volume in the range from about 71% to about 83%.
Claim 15
Dependent Claim
21 words
The method of claim 11 wherein the filter has a voids volume in the range from about 75% to about 80%.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-12-03 | 2000-06-03 | 2000-12-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-12-03 | 2004-06-03 | 2004-12-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-12-03 | 2008-06-03 | 2008-12-03 | $7700.00 | Window Closed / Lapsed |