Patent US1698325A successfully refreshed from Google Patents.
US4608178A
Expired / Lapsed
US
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Method of separating blood components
Assignee: Pfizer Health AB
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Filing: 1984-12-19
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Granted: 1986-08-26
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Expires: 2004-12-19
Abstract
Abstract The invention relates to a method and a blood bag system for the separation of blood components from whole blood, the blood being tapped into a blood bag, which is then centrifugated to form an upper layer containing blood plasma, a lower layer containing red blood cells and an intermediate buffy coat layer, and it is characterized in that the blood is tapped into a first blood bag (1,28) having outlets both at the top (7,30) and at the bottom (1,33), and that after centrifugation the layer containing blood plasma is pressed out through the upper outlet (7,30) of the blood bag while the layer containing red blood cells is pressed out through the lower outlet port (10,33) of the blood bag, so that substantially only the intermediate layer remains in the bag (1,28).
Inventors
- 👤 Anne S. Johansson
- 👤 Claes F. Hogman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 19:50
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/02; A61M1/029; A61M1/0209
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
274 words
A method of separating blood components contained in a blood sample, comprising the steps of: (a) providing a primary blood bag for receiving the blood sample; (b) providing at least two transfer blood bags and at least two conduits, a first of said at least two conduits connecting said primary bag with a first of said at least two transfer blood bags and a second of said at least two conduits connecting said primary bag with a second of said at least two transfer blood bags; (c) collecting a blood sample in the primary blood bag having at least one top portion outlet connecting with the first of said at least two conduits and at least one bottom portion outlet connecting with the second of said at least two conduits; (d) centrifugating said primary blood bag and said transfer blood bags for separating said blood sample into an upper layer containing blood plasma, a lower layer containing red blood cells, and an intermediate layer containing white blood cells; and (e) squeezing said primary bag while said intermediate layer is in fluid contact with each of said upper and lower layers in said primary bag to thereby cause said upper layer to transfer from said primary bag through said at least one top portion outlet and the first of said at least two conduits to said first transfer bag and said lower layer to transfer from said primary bag through said at least one bottom portion outlet and the second of said at least two conduits to said second transfer bag so as to leave essentially only said intermediate layer in said primary blood bag.
Claim 2
Independent Claim
274 words
A method of separating blood components contained in a blood sample, comprising the steps of: (a) providing a primary blood bag for receiving the blood sample; (b) providing at least two transfer blood bags and at least two conduits, a first of said at least two conduits connecting said primary bag with a first of said at least two transfer blood bags and a second of said at least two conduits connecting said primary bag with a second of said at least two transfer blood bags; (c) collecting a blood sample in the primary blood bag having at least one top portion outlet connecting with the first of said at least two conduits and at least one bottom portion outlet connecting with the second of said at least two conduits; (d) centrifugating said primary blood bag and said transfer blood bags for separating said blood sample into an upper layer containing blood plasma, a lower layer containing red blood cells, and an intermediate layer containing white blood cells; and (e) squeezing said primary bag while said intermediate layer is in fluid contact with each of said upper and lower layers in said primary bag to thereby cause said upper layer to transfer from said primary bag through said at least one top portion outlet and the first of said at least two conduits to said first transfer bag and said lower layer to transfer from said primary bag through said at least one bottom portion outlet and the second of said at least two conduits to said second transfer bag so as to leave essentially only said intermediate layer in said primary blood bag.
Claim 3
Dependent Claim
62 words
The method of claim 1, characterized by squeezing out said upper and lower layers through the respective outlet (7, 30; 10, 33) of the primary blood bag by compression of the latter over substantially an entire area thereof, and stopping the compression of the primary blood bag (1, 28) when a pre-determined residual volume remains in the primary blood bag (1, 28).
Claim 4
Dependent Claim
44 words
The method of claim 1 or 2, characterized by the step of controlling said transfer of said upper layer from said primary blood bag so as to maintain said intermediate layer essentially at the same level in the primary blood bag during said squeezing.
Claim 5
Dependent Claim
74 words
The method of claim 3, characterized by the steps of continuously sensing a predetermined level in said primary blood bag and in response thereto closing said at least one top portion outlet when said intermediate layer, or a top portion of said lower layer, reaches said predetermined level, and opening said at least one top portion outlet when said intermediate layer, or a top portion of said lower layer, falls below said pre-determined level.
Claim 6
Dependent Claim
52 words
The method of claim 1 or 2, characterized by stopping flow of said upper layer when said intermediate layer, or top portion of said lower layer, has reached a pre-determined level, and continuing squeezing out of said lower layer until a pre-determined residual volume remains in said primary blood bag (1, 28).
Claim 7
Dependent Claim
41 words
The method of claim 5, characterized by simultaneously adding an anti-coagulant to the blood sample with said collecting of said blood sample in said primary blood bag, said anti-coagulant being supplied from a separate bag connected to said primary blood bag.
Claim 8
Dependent Claim
41 words
The method of claim 1, characterized by simultaneously adding an anti-coagulant to the blood sample with said collecting of said blood sample in said primary blood bag, said anti-coagulant being supplied from a separate bag connected to said primary blood bag.
Claim 9
Independent Claim
259 words
A method of separating blood components contained in a blood sample, comprising the steps of: (a) providing a primary blood bag for receiving the blood sample; (b) providing a common blood bag and at least two conduits, a first of said at least two conduits connecting said primary bag with said common blood bag and a second of said at least two conduits connecting said primary bag with said common blood bag; (c) collecting a blood sample in the primary blood bag having at least one top portion outlet connecting with the first of said at least two conduits and at least one bottom portion outlet connecting with the second of said at least two conduits; (d) centrifugating said primary blood bag and said common blood bag for separating said blood sample into an upper layer containing blood plasma, a lower layer containing red blood cells and an intermediate layer containing white blood cells; (e) squeezing said primary bag while said intermediate layer is in fluid contact with each of said upper and lower layers in said primary bag to thereby cause said upper layer to transfer from said primary bag through said at least one top portion outlet and the first of said at least two conduits to said common blood bag and said lower layer to transfer from said primary bag through said at least one bottom portion outlet and the second of said at least two conduits to said common blood bag so as to leave essentially only said intermediate layer in said primary blood bag.
Claim 10
Independent Claim
259 words
A method of separating blood components contained in a blood sample, comprising the steps of: (a) providing a primary blood bag for receiving the blood sample; (b) providing a common blood bag and at least two conduits, a first of said at least two conduits connecting said primary bag with said common blood bag and a second of said at least two conduits connecting said primary bag with said common blood bag; (c) collecting a blood sample in the primary blood bag having at least one top portion outlet connecting with the first of said at least two conduits and at least one bottom portion outlet connecting with the second of said at least two conduits; (d) centrifugating said primary blood bag and said common blood bag for separating said blood sample into an upper layer containing blood plasma, a lower layer containing red blood cells and an intermediate layer containing white blood cells; (e) squeezing said primary bag while said intermediate layer is in fluid contact with each of said upper and lower layers in said primary bag to thereby cause said upper layer to transfer from said primary bag through said at least one top portion outlet and the first of said at least two conduits to said common blood bag and said lower layer to transfer from said primary bag through said at least one bottom portion outlet and the second of said at least two conduits to said common blood bag so as to leave essentially only said intermediate layer in said primary blood bag.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-08-25 | 1990-02-24 | 1990-08-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-08-25 | 1994-02-24 | 1994-08-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-08-25 | 1998-02-24 | 1998-08-26 | $7700.00 | Window Closed / Lapsed |