US5362406A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Leucocyte depleting filter device and method of use
Assignee: Pall Corp
•
Filing: 1994-03-09
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Granted: 1994-11-08
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Expires: 2014-03-09
Abstract
Abstract Leucocyte depletion filter assemblies and methods for removing leucocytes and other deleterious matter from a leucocyte-containing liquid are disclosed. Leucocyte depletion filter assemblies have a generally cylindrical housing having first and second chambers and an inlet into the first chamber and an outlet from the second chamber and a vent. A porous degassing element is positioned between the first and second chambers to remove gas from the liquid and the degassing element communicates with a vent covered with a liquophobic membrane which allows gas but not the liquid to flow through the vent. A hollow, cylindrical filter element is positioned in the second chamber and comprises a fibrous mass of microfibers capable of decreasing the leucocyte content of the liquid at a flow rate capacity of six liters per minute at a differential pressure of less than 15 psi. The mass of microfibers have a CWST of at least 53 dynes/cm and a graded pore size over at least a substantial radial portion of the microfibrous mass. The interior of the hollow filter element communicates with the outlet. These filter assemblies are suitable for use in an extracorporeal circuit. Leucocytes and other deleterious matter are removed from the leucocyte-containing liquid by passing the leucocyte-containing liquid through these filter assemblies.
Inventors
- 👤 Thomas C. Gsell
- 👤 Vlado I. Matkovich
- 👤 Thomas Bormann
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 02:36
CPC Classifications
B; B01; B01D; B01D39/00; B01D39/14; B01D39/16; B01D39/1607; B01D39/1623; A; A61; A61M; A61M1/00; A61M1/36; A61M1/3621; A61M1/3627; A61M1/3633; A61M2202/00; A61M2202/04; A61M2202/0413; A61M2202/0439; A61M2205/00; A61M2205/75; A61M2205/7536; A61M2206/00; A61M2206/10; A61M2206/16
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
177 words
A leucocyte depletion filter assembly for removing leucocytes and other deleterious matter from a leucocyte-containing liquid, the filter assembly comprising: a generally cylindrical housing having first and second chambers, an inlet which allows tangential inflow into the first chamber, an outlet which allows outflow from the second chamber, and a vent; a porous degassing element positioned between the first and second chambers to remove gas from the liquid; a liquophobic membrane covering the vent and communicating with the degassing element to allow gas but not the liquid to flow through the vent; and a hollow, cylindrical filter element positioned in the second chamber and comprising a fibrous mass of microfibers capable of decreasing the leucocyte content of the liquid at a flow rate capacity of six liters per minute at a differential pressure of less than 15 psi, said mass of microfibers having a CWST of at least 53 dynes/cm and a graded pore size over at least a substantial radial portion of the microfibrous mass, the interior of the hollow filter element communicating with the outlet.
Claim 2
Dependent Claim
177 words
A leucocyte depletion filter assembly for removing leucocytes and other deleterious matter from a leucocyte-containing liquid, the filter assembly comprising: a generally cylindrical housing having first and second chambers, an inlet which allows tangential inflow into the first chamber, an outlet which allows outflow from the second chamber, and a vent; a porous degassing element positioned between the first and second chambers to remove gas from the liquid; a liquophobic membrane covering the vent and communicating with the degassing element to allow gas but not the liquid to flow through the vent; and a hollow, cylindrical filter element positioned in the second chamber and comprising a fibrous mass of microfibers capable of decreasing the leucocyte content of the liquid at a flow rate capacity of six liters per minute at a differential pressure of less than 15 psi, said mass of microfibers having a CWST of at least 53 dynes/cm and a graded pore size over at least a substantial radial portion of the microfibrous mass, the interior of the hollow filter element communicating with the outlet.
Claim 3
Dependent Claim
23 words
The filter assembly of claim 1 wherein the filter element includes a total fibrous surface area of greater than about two square meters.
Claim 4
Dependent Claim
29 words
The filter assembly of claim 1 wherein the fibrous mass includes an upstream portion and a downstream portion, the upstream portion comprising generally coarser fibers than the downstream portion.
Claim 5
Dependent Claim
23 words
The filter assembly of claim 1 including a hold up volume in the range of from about 70 cc to about 400 cc.
Claim 6
Dependent Claim
23 words
The filter assembly of claim 4 including a hold up volume in the range of from about 180 cc to about 250 cc.
Claim 7
Independent Claim
142 words
A method for removing leucocytes and other deleterious matter from a leucocyte-containing liquid comprising: directing the liquid through a housing; passing the liquid through a porous degassing element disposed within the housing; venting gas from the housing through a vent in communication with the degassing element, wherein the vent includes a liquophobic membrane which allows the gas but not the liquid to flow through the vent; and passing the liquid through a hollow, cylindrical filter element positioned within the housing, the filter element comprising a fibrous mass capable of decreasing the leucocyte content of the liquid at a flow rate capacity of six liters per minute at a differential pressure of less than 15 psi, said fibrous mass having a CWST of at least 53 dynes/cm and a graded pore size over at least a substantial radial portion of the fibrous mass.
Claim 8
Independent Claim
142 words
A method for removing leucocytes and other deleterious matter from a leucocyte-containing liquid comprising: directing the liquid through a housing; passing the liquid through a porous degassing element disposed within the housing; venting gas from the housing through a vent in communication with the degassing element, wherein the vent includes a liquophobic membrane which allows the gas but not the liquid to flow through the vent; and passing the liquid through a hollow, cylindrical filter element positioned within the housing, the filter element comprising a fibrous mass capable of decreasing the leucocyte content of the liquid at a flow rate capacity of six liters per minute at a differential pressure of less than 15 psi, said fibrous mass having a CWST of at least 53 dynes/cm and a graded pore size over at least a substantial radial portion of the fibrous mass.
Claim 9
Dependent Claim
20 words
The method of claim 6 wherein passing the leucocyte-containing liquid through the filter element includes passing blood through the element.
Claim 10
Dependent Claim
20 words
The method of claim 6 wherein directing the leucocyte-containing liquid through the housing comprises repeatedly circulating blood through the housing.
Claim 11
Dependent Claim
23 words
The method of claim 41 wherein passing the leucocyte-containing liquid through the filter element comprises passing the liquid through a fibrous depth filter.
Claim 12
Dependent Claim
29 words
The method of claim 6 wherein passing the leucocyte-containing liquid through the filter element comprises decreasing the leucocyte content of the liquid by a clinically or therapeutically significant amount.
Claim 13
Dependent Claim
27 words
The method of claim 6 comprising passing the leucocyte-containing liquid through the filter element having a total fibrous surface area of greater than about two square meters.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-11-07 | 1998-05-09 | 1998-11-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-11-07 | 2002-05-09 | 2002-11-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-11-07 | 2006-05-09 | 2006-11-08 | $7700.00 | Window Closed / Lapsed |