US5151192A
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US
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Method for removing heparin from blood or plasma
Assignee: Pall Corp
•
Filing: 1990-07-13
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Granted: 1992-09-29
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Expires: 2010-07-13
Abstract
Abstract A porous medium having a positive surface change removes heparin from a heparin-containing liquid, without removing other proteinaceous components from the liquid. Methods and devices are disclosed.
Inventors
- 👤 Vlado I. Matkovich
- 👤 Peter J. Degen
- 👤 Thomas C. Gsell
- 👤 Thomas Bormann
- 👤 Isaac Rothman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 21:28
CPC Classifications
C; C08; C08B; C08B37/00; C08B37/0003; A; A61; A61M; A61M1/00; A61M1/36; A61M1/3672; A61M1/3675; A61M1/34; B; B01; B01D; B01D15/00; B01J; B01J20/00; B01J20/22; B01J20/26; B01J41/00; B01J41/04; B01J41/08; B01J41/12; B01J41/14; B01J47/00; B01J47/018; C08B37/006; C08B37/0063; C08B37/0075; Y; Y10; Y10T; Y10T436/00; Y10T436/25; Y10T436/25375; Y10T436/255
Claims Analysis
Total Claims: 42
Claim 1
Independent Claim
52 words
A method for removing heparin from blood or plasma comprising: contacting the blood or plasma with a porous medium having a positively charged surface and being capable of removing heparin from blood or plasma without pH adjustment; and removing heparin from the blood or plasma without substantial removal of blood clotting factors.
Claim 2
Independent Claim
52 words
A method for removing heparin from blood or plasma comprising: contacting the blood or plasma with a porous medium having a positively charged surface and being capable of removing heparin from blood or plasma without pH adjustment; and removing heparin from the blood or plasma without substantial removal of blood clotting factors.
Claim 3
Dependent Claim
15 words
The method of claim 1 wherein the positively charged surface contains amino or ammonium groups.
Claim 4
Dependent Claim
18 words
The method of claim 2 wherein the positively charged surface is derived from trimethyl ammonium ethyl acrylic chloride.
Claim 5
Dependent Claim
13 words
The method of claim 3 wherein the blood is in an extracorporeal circuit.
Claim 6
Dependent Claim
16 words
The method of claim 2 wherein the positively charged surface is derived from diethylamino ethyl methacrylate.
Claim 7
Dependent Claim
13 words
The method of claim 5 wherein the blood is in an extracorporeal circuit.
Claim 8
Dependent Claim
15 words
The method of claim 1 wherein the positively charged surface contains amino and ammonium groups.
Claim 9
Dependent Claim
14 words
The method of claim 1 wherein the positively charged surface contains quaternary ammonium groups.
Claim 10
Dependent Claim
25 words
The method of claim 1 wherein the positively charged surface is derived from trimethyl ammonium ethyl acrylic chloride and a polar, non-ionic, ethylenically unsaturated monomer.
Claim 11
Dependent Claim
16 words
The method of claim 9 wherein the polar, non-ionic, ethylenically unsaturated monomer is diethylene glycol dimethacrylate.
Claim 12
Dependent Claim
13 words
The method of claim 9 wherein the blood is in an extracorporeal circuit.
Claim 13
Dependent Claim
23 words
The method of claim 1 wherein the positively charged surface is derived from diethylamino ethyl methacrylate and a polar, non-ionic, ethylenically unsaturated monomer.
Claim 14
Dependent Claim
15 words
The method of claim 12 wherein the polar, nonionic, ethylenically unsaturated monomer is methyl methacrylate.
Claim 15
Dependent Claim
13 words
The method of claim 12 wherein the blood is in an extracorporeal circuit.
Claim 16
Dependent Claim
21 words
The method of claim 1 wherein the porous medium is a polymeric fibrous matrix, polymeric membrane, or a rigid porous medium.
Claim 17
Dependent Claim
22 words
The method of claim 1 wherein the porous medium is a polymer selected from the group consisting of polyolefins, polyesters, and polyamides.
Claim 18
Dependent Claim
12 words
The method of claim 16 wherein the porous medium is polybutylene terephthalate.
Claim 19
Dependent Claim
54 words
The method of claim 1 wherein the porous medium comprises a substrate selected from the group consisting of polyolefins, polyesters, and polyamides, and at least one superstrate selected from group consisting of a) trimethyl ammonium ethyl acrylic chloride; b) diethylamino ethyl methacrylate; c) "a" and diethylene glycol dimethacrylate; and d) "b" and methyl methacrylate.
Claim 20
Dependent Claim
13 words
The method of claim 18 wherein the blood is in an extracorporeal circuit.
Claim 21
Dependent Claim
28 words
The method of claim 1 wherein the surface area of the medium is in the range from about 0.01 m 2 /g to about 20 M 2 /g.
Claim 22
Dependent Claim
28 words
The method of claim 20 wherein the surface area of the medium is in the range from about 0.2 M 2 /g to about 10 M 2 /g.
Claim 23
Dependent Claim
19 words
The method of claim 1 wherein the average residence time is from about 0.1 second to about 50 seconds.
Claim 24
Dependent Claim
11 words
The method of claim 1 wherein the porous medium is self-supporting.
Claim 25
Dependent Claim
13 words
The method of claim 1 wherein the blood is in an extracorporeal circuit.
Claim 26
Dependent Claim
27 words
The method of claim 24 wherein the blood flows through a filter assembly in the extracorporeal circuit at a rate of about 2.5 to about 6 liters/minute.
Claim 27
Independent Claim
67 words
A method for returning the coagulation parameters of a heparin-containing blood or plasma sample to their accurate values comprising passing the sample through a porous medium comprising a substrate and a superstrate, said porous medium having a positively charged surface and being capable of removing heparin from blood or plasma without pH adjustment and without substantial removal of blood clotting factors, thereby removing heparin from the sample.
Claim 28
Independent Claim
67 words
A method for returning the coagulation parameters of a heparin-containing blood or plasma sample to their accurate values comprising passing the sample through a porous medium comprising a substrate and a superstrate, said porous medium having a positively charged surface and being capable of removing heparin from blood or plasma without pH adjustment and without substantial removal of blood clotting factors, thereby removing heparin from the sample.
Claim 29
Dependent Claim
25 words
The method of claim 26 wherein the positively charged surface is derived from trimethyl ammonium ethyl acrylic chloride and a polar, non-ionic, ethylenically unsaturated monomer.
Claim 30
Dependent Claim
16 words
The method of claim 27 wherein the polar, non-ionic, ethylenically unsaturated monomer is diethylene glycol dimethacrylate.
Claim 31
Dependent Claim
23 words
The method of claim 26 wherein the positively charged surface is derived from diethylamino ethyl methacrylate and a polar, non-ionic, ethylenically unsaturated monomer.
Claim 32
Dependent Claim
15 words
The method of claim 29 wherein the polar, nonionic, ethylenically unsaturated monomer is methyl methacrylate.
Claim 33
Dependent Claim
21 words
The method of claim 26 wherein the substrate is a polymer selected from the group consisting of polyolefins, polyesters, and polyamides.
Claim 34
Dependent Claim
11 words
The method of claim 26 wherein the substrate is polybutylene terephthalate.
Claim 35
Dependent Claim
54 words
The method of claim 26 wherein the porous medium comprises a substrate selected from the group consisting of polyolefins, polyesters, and polyamides, and at least one superstrate selected from group consisting of a) trimethyl ammonium ethyl acrylic chloride; b) diethylamino ethyl methacrylate; c) "a" and diethylene glycol dimethacrylate; and d) "b" and methyl methacrylate.
Claim 36
Dependent Claim
28 words
The method of claim 26 wherein the surface area of the medium is in the range from about 0.01 M 2 /g to about 20 M 2 /g.
Claim 37
Dependent Claim
28 words
The method of claim 34 wherein the surface area of the medium is in the range from about 0.2 M 2 /g to about 10 M 2 /g.
Claim 38
Dependent Claim
19 words
The method of claim 26 wherein the average residence time is from about 0.1 second to about 50 seconds.
Claim 39
Independent Claim
60 words
A method for removing heparin from blood or plasma comprising: contacting the blood or plasma with a porous medium having a positively charged surface and being capable of removing heparin from blood or plasma without pH adjustment and without substantial removal of blood clotting factors; and removing a therapeutically or clinically significant amount of heparin from the blood or plasma.
Claim 40
Independent Claim
60 words
A method for removing heparin from blood or plasma comprising: contacting the blood or plasma with a porous medium having a positively charged surface and being capable of removing heparin from blood or plasma without pH adjustment and without substantial removal of blood clotting factors; and removing a therapeutically or clinically significant amount of heparin from the blood or plasma.
Claim 41
Dependent Claim
55 words
The method of claim 37 wherein the porous medium comprises a substrate selected from the group consisting of polyolefins, polyesters, and polyamides, and at least one superstrate selected from the group consisting of a) trimethyl ammonium ethyl acrylic chloride; b) diethylamino ethyl methacrylate; c) "a" and diethylene glycol dimethacrylate; and d) "b" and methyl methacrylate.
Claim 42
Dependent Claim
14 words
The method of claim 37 wherein the substrate is a polybutylene terephthalate fiber matrix.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-09-29 | 1996-03-30 | 1996-09-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-09-29 | 2000-03-30 | 2000-09-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-09-29 | 2004-03-30 | 2004-09-29 | $7700.00 | Window Closed / Lapsed |