EP0219053A2
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EP
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Blood filtration devices with heparin coated filter elements
Assignee: Baxter International Inc
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Filing: 1986-10-07
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Granted: —
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Expires: 2006-10-07
Abstract
Abstract Heparin coated blood filtration devices prepared in a one-step process by applying a heparin coating to the porous substrate of a blood filter element. The heparin coating provides improved porous blood filtration devices useful, for example, in cardiopulmonary bypass arterial blood filters.
Inventors
- 👤 Li-Chien Hsu
- 👤 David P. Balding
- 👤 Rolf W. Clarke
- 👤 Karl E. Mosch
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-31 02:33
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/36; A61M1/3621; A61M1/3627; A61M1/3672; A61M1/3673
Claims Analysis
Total Claims: 38
Claim 1
Independent Claim
23 words
A blood filter element suitable for use in a blood filtration device, comprising a porous filter substrate coated with a heparin-cationic surfactant complex.
Claim 2
Dependent Claim
23 words
A blood filter element suitable for use in a blood filtration device, comprising a porous filter substrate coated with a heparin-cationic surfactant complex.
Claim 3
Dependent Claim
12 words
A blood filtration device utilizing the blood filter element of claim l.
Claim 4
Dependent Claim
22 words
The blood filtration device of claim 2, wherein said device is an integral blood filter, a blood oxygenator, or a blood reservoir.
Claim 5
Dependent Claim
63 words
A blood filter element suitable for use in a blood filter device, comprising: a porous filter substrate; a network of pores within said porous filter substrate suitable for the passage and filtration of blood; a coating of heparin-cationic surfactant complex applied to the pore walls of said pores in such a manner as substantially to coat said walls without substantially occluding said pores.
Claim 6
Dependent Claim
63 words
A blood filter element suitable for use in a blood filter device, comprising: a porous filter substrate; a network of pores within said porous filter substrate suitable for the passage and filtration of blood; a coating of heparin-cationic surfactant complex applied to the pore walls of said pores in such a manner as substantially to coat said walls without substantially occluding said pores.
Claim 7
Dependent Claim
12 words
A blood filtration device utilizing the blood filter element of claim 4.
Claim 8
Dependent Claim
22 words
The blood filter device of claim 5, wherein said device is an integral blood filter, a blood oxygenator, or a blood reservoir.
Claim 9
Dependent Claim
53 words
A blood filter element suitable for use in a blood filtration device, comprising: a porous filter substrate; a coating of heparin-cationic surfactant complex applied to said porous filter substrate; a component of said heparin-cationic surfactant complex consisting of a cationic surfactant containing at least one alkyl chain of at least four carbon atoms.
Claim 10
Dependent Claim
53 words
A blood filter element suitable for use in a blood filtration device, comprising: a porous filter substrate; a coating of heparin-cationic surfactant complex applied to said porous filter substrate; a component of said heparin-cationic surfactant complex consisting of a cationic surfactant containing at least one alkyl chain of at least four carbon atoms.
Claim 11
Dependent Claim
12 words
A blood filtration device utilizing the blood filter element of claim 7.
Claim 12
Dependent Claim
22 words
The blood filter device of claim 8, wherein said device is an integral blood filter, a blood oxygenator, or a blood reservoir.
Claim 13
Dependent Claim
89 words
l0. A blood filter element suitable for use in a blood filtration device, comprising: a porous filter substrate; a network of pores within said porous filter substrate suitable for the passage and filtration of blood; a coating of heparin-cationic surfactant complex applied to the pore walls of said pores in such a manner as substantially to coat said pore walls without substantially occluding said pores; a component of said heparin-cationic surfactant complex consisting of a cationic surfactant containing at least one alkyl chain of at least four carbon atoms.
Claim 14
Dependent Claim
89 words
l0. A blood filter element suitable for use in a blood filtration device, comprising: a porous filter substrate; a network of pores within said porous filter substrate suitable for the passage and filtration of blood; a coating of heparin-cationic surfactant complex applied to the pore walls of said pores in such a manner as substantially to coat said pore walls without substantially occluding said pores; a component of said heparin-cationic surfactant complex consisting of a cationic surfactant containing at least one alkyl chain of at least four carbon atoms.
Claim 15
Dependent Claim
12 words
A blood filtration device utilizing the blood filter element of claim l0.
Claim 16
Dependent Claim
22 words
The blood filtration device of claim ll, wherein said device is an integral blood filter, a blood oxygenator, or a blood reservoir.
Claim 17
Dependent Claim
21 words
The blood filter element of claim l0, wherein said porous filter substrate is a foam, a screen, or a felt material.
Claim 18
Dependent Claim
35 words
The blood filter element of claim l0, wherein said porous filter substrate is of a material selected from the group consisting of polyesters, nylons, polyolefins, acrylics, fluorinated hydrocarbons, polyurethanes, polycarbonates, or cellulose or cellulose derivatives.
Claim 19
Dependent Claim
16 words
The blood filter element of claim l4, wherein said polyester is polyethylene terephthalate or polybutylene terephthalate.
Claim 20
Dependent Claim
22 words
The blood filter element of claim l4, wherein said polyolefin is a polyethylene or polypropylene or a copolymer of ethylene and propylene.
Claim 21
Dependent Claim
13 words
The blood filter element of claim l4, wherein said fluorinated hydrocarbon is polytetrafluoroethylene.
Claim 22
Dependent Claim
14 words
The blood filter element of claim l4, wherein said cellulose derivative is cellulose acetate.
Claim 23
Dependent Claim
24 words
The blood filter element of claim l0, wherein said pores are characterized by pore sizes ranging from about l0 microns to about l50 microns.
Claim 24
Dependent Claim
32 words
The blood filtration device of claim ll, wherein said device is an arterial blood filter including a porous filter substrate having pore sizes ranging from about 20 microns to about 45 microns.
Claim 25
Dependent Claim
33 words
2l. The blood filtration device of claim ll, wherein said device is a venous blood reservoir including a porous filter substrate having pore sizes ranging from about 80 microns to about l20 microns.
Claim 26
Dependent Claim
25 words
The blood filter element of claim l0, wherein said cationic surfactant contains at least one alkyl chain of about 8 to about l8 carbon atoms.
Claim 27
Dependent Claim
23 words
The blood filter element of claim l0, wherein said cationic surfactant is a primary, secondary, or tertiary amine, or a quaternary ammonium compound.
Claim 28
Dependent Claim
35 words
The blood filter element of claim l0, wherein said cationic surfactant is a dimethylalkylbenzyl ammonium compound, the alkyl group of said compound having a chain length of from about 8 to about l8 carbon atoms.
Claim 29
Dependent Claim
17 words
The blood filter element of claim l0, wherein said cationic surfactant is a mixture of benzalkonium cations.
Claim 30
Dependent Claim
16 words
The blood filter element of claim l0, wherein said cationic surfactant is the tridodecylmethyl ammonium cation.
Claim 31
Dependent Claim
69 words
A process for heparin coating a porous filter element for a blood filtration device, comprising: preparing a solution of a heparin-cationic surfactant complex in a solvent, dipping said porous filter element for a blood filtration device in said solution, removing said porous filter element for a blood filtration device from said solution, and evaporating said solvent to yield a heparin coated porous filter element for a blood filtration device.
Claim 32
Dependent Claim
69 words
A process for heparin coating a porous filter element for a blood filtration device, comprising: preparing a solution of a heparin-cationic surfactant complex in a solvent, dipping said porous filter element for a blood filtration device in said solution, removing said porous filter element for a blood filtration device from said solution, and evaporating said solvent to yield a heparin coated porous filter element for a blood filtration device.
Claim 33
Dependent Claim
27 words
The process for heparin coating a porous filter element for a blood filtration device as set forth in claim 27, wherein said solvent is a lower alcohol.
Claim 34
Dependent Claim
25 words
The process for heparin coating a porous filter element for a blood filtration device as set forth in claim 27, wherein said alcohol is 2-propanol.
Claim 35
Dependent Claim
32 words
The process for heparin coating a porous filter element for a blood filtration device as set forth in claim 27, wherein said solution concentration ranges from about 0.02% to about l0% (w/v).
Claim 36
Dependent Claim
33 words
3l. The process for heparin coating a porous filter element for a blood filtration device as set forth in claim 27, wherein said solution concentration ranges from about 0.2 to about l% (w/v).
Claim 37
Dependent Claim
32 words
The process for heparin coating a porous filter element for a blood filtration device as set forth in claim 27, including dipping said porous filter element in said solution at about 20°C.
Claim 38
Dependent Claim
37 words
The process for heparin coating a porous filter element for a blood filtration device as set forth in claim 27, including drying said heparin coated blood filtration device at a temperature between about 40° and about 70°C.
References Cited (Backward Citations)
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