US5360545A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Filter for obtaining platelets
Assignee: Pall Corp
•
Filing: 1993-08-03
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Granted: 1994-11-01
•
Expires: 2013-08-03
Abstract
Abstract The invention provides processing donated blood, particularly a platelet-containing solution such as platelet-containing plasma, involving separating blood into a red cell containing sediment layer and a supernatant layer, and passing the supernatant layer through a filter until the filter is blocked, thereby leaving platelets to be harvested. The preferred filter comprises a porous medium having a plurality of zones of progressively increasing density.
Inventors
- 👤 David B. Pall
- 👤 Thomas C. Gsell
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 03:10
CPC Classifications
B; B01; B01D; B01D63/00; B01D63/08; B01D63/087; A; A61; A61M; A61M1/00; A61M1/02; A61M1/0209; A61M1/0218; A61M1/0227; A61M1/0231; A61M1/029; A61M1/36; A61M1/3621; A61M1/3627; A61M1/3633; A61M1/3643; A61M1/3644; A61M1/3646; A61M1/3652; B01D39/00; B01D39/14; B01D39/16; B01D39/1607; B01D39/1623; B01D61/00; B01D61/14; B01D61/147; B01D61/16; A61J; A61J1/00; A61J1/05; A61J1/10; A61M1/3693; A61M2202/00; A61M2202/04; A61M2202/0413; A61M2202/0415; A61M2202/0427; A61M2202/0429; A61M2202/0439; A61M2206/00; A61M2206/10; A61M2206/12
Claims Analysis
Total Claims: 36
Claim 1
Independent Claim
33 words
A device for harvesting platelets from a platelet-containing solution comprising a porous medium which blocks red blood cells, but which permits platelets to pass therethrough, said porous medium having zones of different density.
Claim 2
Independent Claim
33 words
A device for harvesting platelets from a platelet-containing solution comprising a porous medium which blocks red blood cells, but which permits platelets to pass therethrough, said porous medium having zones of different density.
Claim 3
Dependent Claim
11 words
The device of claim 1 wherein the porous medium is fibrous.
Claim 4
Dependent Claim
17 words
The device of claim 2 wherein the porous medium has a CWST greater than about 70 dynes/cm.
Claim 5
Dependent Claim
24 words
The device of claim 3 wherein the porous medium has a flow area of about 3 cm 2 to about 8 cm 2 .
Claim 6
Dependent Claim
25 words
The device of claim 2 wherein the porous medium includes fibers modified by exposure to a monomer comprising a polymerizable group and a hydroxyl-containing group.
Claim 7
Dependent Claim
11 words
The device of claim 5 wherein the monomer is hydroxyethyl methacrylate.
Claim 8
Dependent Claim
22 words
The device of claim 6 wherein the fibers of the porous medium have been modified to present hydroxyl groups and carboxyl groups.
Claim 9
Dependent Claim
26 words
The device of claim 7 wherein the fibers of the porous medium have been modified with a mixture of monomers comprising hydroxyethyl methacrylate and methacrylic acid.
Claim 10
Dependent Claim
30 words
The device of claim 8 wherein the weight ratio of the methacrylic acid monomer to the hydroxyethyl methacrylate monomer in the modifying mixture is between about 0.01:1 and about 0.5:1.
Claim 11
Dependent Claim
18 words
The device of claim 9 wherein the ratio in the modifying mixture is about 0.05:1 to about 0.35:1.
Claim 12
Dependent Claim
13 words
The device of claim 10 wherein the porous medium comprises polybutylene terephthalate fibers.
Claim 13
Dependent Claim
23 words
The device of claim 10 wherein the flow area of the fibrous porous medium is about 3 to about 8 cm 2 .
Claim 14
Dependent Claim
18 words
The device of claim 12 wherein the flow area is about 4 to about 6 cm 2 .
Claim 15
Dependent Claim
26 words
The device of claim 10 wherein the zeta potential of the fibrous porous medium is about -3 to about -30 millivolts at a pH of 7.3.
Claim 16
Dependent Claim
14 words
The device of claim 10 including a hold-up volume less than about 1 cc.
Claim 17
Dependent Claim
17 words
The device of claim 1 wherein the porous medium comprises at least two zones of different density.
Claim 18
Dependent Claim
13 words
The device of claim 16 wherein each zone is of successively increasing density.
Claim 19
Dependent Claim
52 words
The device of claim 17 wherein an upstream zone includes a density range from about 0.1 g/cc to about 0.2 g/cc, an intermediate zone includes a density range from about 0.20 g/cc to about 0.25 g/cc, and a downstream zone includes a density range from about 0.23 g/cc to about 0.40 g/cc.
Claim 20
Dependent Claim
37 words
The device of claim 16 wherein an upstream zone includes a density range from about 0.18 g/cc to about 0.23 g/cc, and a downstream zone includes a density range from about 0.23 g/cc to about 0.40 g/cc.
Claim 21
Dependent Claim
14 words
The device of claim 16 wherein the porous medium has a negative zeta potential.
Claim 22
Dependent Claim
14 words
The device of claim 9 including a hold-up volume less than about 1 ml.
Claim 23
Independent Claim
82 words
A system for the collection and processing of blood comprising: a blood collection bag and at least one satellite bag connected thereto; a porous medium interposed between the blood collection bag and a satellite bag, the porous medium comprising fibers having a CWST of greater than about 70 dynes/cm, at least two zones of different density between about 0.1 g/cc and about 0.4 g/cc, and said porous medium bars the passage of red blood cells therethrough, but permits the passage of platelets.
Claim 24
Independent Claim
82 words
A system for the collection and processing of blood comprising: a blood collection bag and at least one satellite bag connected thereto; a porous medium interposed between the blood collection bag and a satellite bag, the porous medium comprising fibers having a CWST of greater than about 70 dynes/cm, at least two zones of different density between about 0.1 g/cc and about 0.4 g/cc, and said porous medium bars the passage of red blood cells therethrough, but permits the passage of platelets.
Claim 25
Dependent Claim
14 words
The system of claim 22 wherein the porous medium has a negative zeta potential.
Claim 26
Independent Claim
44 words
A device for producing a platelet suspension comprising: a porous medium that decreases red blood cell contamination by permitting the passage of platelets until the medium is blocked by red blood cells; said medium having zones of different density, and a negative zeta potential.
Claim 27
Independent Claim
44 words
A device for producing a platelet suspension comprising: a porous medium that decreases red blood cell contamination by permitting the passage of platelets until the medium is blocked by red blood cells; said medium having zones of different density, and a negative zeta potential.
Claim 28
Dependent Claim
22 words
The device of claim 24 wherein the porous medium comprises a fibrous medium having a CWST of greater than about 70 dynes/cm.
Claim 29
Dependent Claim
17 words
The device of claim 25 wherein the CWST is from about 90 dynes/cm to about 100 dynes/cm.
Claim 30
Dependent Claim
17 words
The device of claim 26 wherein the CWST is from about 93 dynes/cm to about 97 dynes/cm.
Claim 31
Dependent Claim
17 words
The device of claim 24 wherein the porous medium is preformed prior to assembly into a housing.
Claim 32
Dependent Claim
39 words
The device of claim 24 further comprising a housing including an inlet and an outlet and defining a fluid flow path between the inlet and the outlet, said porous medium disposed in the housing across the fluid flow path.
Claim 33
Dependent Claim
18 words
The device of claim 29 wherein the housing includes a radially positioned inlet and a radially positioned outlet.
Claim 34
Dependent Claim
34 words
The device of claim 30 wherein the housing includes at least one rib facing the upstream side of the porous medium, and at least one channel facing the downstream side of the porous medium.
Claim 35
Dependent Claim
22 words
The device of claim 31 wherein the housing includes concentric grooves and radial channels facing the downstream side of the porous medium.
Claim 36
Dependent Claim
13 words
The device of claim 29 further comprising a container downstream of the housing.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-10-31 | 1998-05-02 | 1998-11-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-10-31 | 2002-05-02 | 2002-11-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-10-31 | 2006-05-02 | 2006-11-01 | $7700.00 | Window Closed / Lapsed |