Patent US4307072A successfully refreshed from Google Patents.
Patent US5403275A successfully refreshed from Google Patents.
US5403275A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method for reducing sensation in iontophoretic drug delivery
Assignee: Alza Corp
•
Filing: 1993-06-21
•
Granted: 1995-04-04
•
Expires: 2013-06-21
Abstract
Abstract Methods for delivering therapeutic agents by iontophoresis with reduced or mitigated sensation are disclosed. The methods generally involve the step of delivering therapeutic agent by iontophoresis in the presence of an intentionally added sensation reducing amount of a multivalent ion. Preferred multivalent ions useful to mitigate sensation are calcium, magnesium, phosphate and zinc.
Inventors
- 👤 J. Bradley Phipps
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 22:40
CPC Classifications
A; A61; A61N; A61N1/00; A61N1/18; A61N1/20; A61N1/30
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
92 words
A method of reducing sensation of electrical current in operation of an iontophoretic drug delivery device comprising the steps of: a. providing an iontophoresis drug delivery device comprising a power source, an electrode assembly electrically coupled to the power source having a reservoir containing an agent to be iontophoretically delivered; b. intentionally adding an amount of physiologically acceptable multivalent ion to the apparatus reservoir sufficient to reduce sensation during drug delivery; c. placing the apparatus in contact with tissue; and d. operating the device to co-deliver a drug and said multivalent ion.
Claim 2
Independent Claim
92 words
A method of reducing sensation of electrical current in operation of an iontophoretic drug delivery device comprising the steps of: a. providing an iontophoresis drug delivery device comprising a power source, an electrode assembly electrically coupled to the power source having a reservoir containing an agent to be iontophoretically delivered; b. intentionally adding an amount of physiologically acceptable multivalent ion to the apparatus reservoir sufficient to reduce sensation during drug delivery; c. placing the apparatus in contact with tissue; and d. operating the device to co-deliver a drug and said multivalent ion.
Claim 3
Dependent Claim
12 words
A method according to claim 1 wherein the multivalent ion is divalent.
Claim 4
Dependent Claim
12 words
A method according to claim 1 wherein the multivalent ion is positive.
Claim 5
Dependent Claim
14 words
A method according to claim 1 wherein the multivalent ion is divalent and positive.
Claim 6
Dependent Claim
22 words
A method according to claim 1 wherein the multivalent ion is selected from the group consisting of calcium, zinc, magnesium, and phosphate.
Claim 7
Dependent Claim
23 words
A method according to claim 1 wherein the multivalent ion is calcium and is present at a concentration of about 10 mole percent.
References Cited (Backward Citations)
GB410009A
Cited
US3991755A
Cited
US4405616A
Cited
US3989816A
Cited
US4141359A
Cited
US4211222A
Cited
US4340047A
Cited
US4250878A
Cited
US4398545A
Cited
US4415563A
Cited
US4424210A
Cited
US4382529A
Cited
EP0058920A1
Cited
US4406658A
Cited
US4744787A
Cited
US4747819A
Cited
US4752285A
Cited
US4752285B1
Cited
EP0318776A1
Cited
US5167616A
Cited
US5221254A
Cited
US5246418A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1998-04-03 | 1998-10-03 | 1999-04-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-04-03 | 2002-10-03 | 2003-04-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-04-03 | 2006-10-03 | 2007-04-04 | $7700.00 | Window Closed / Lapsed |