US4747819A
Expired / Lapsed
US
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Iontophoretic drug delivery
Assignee: Alza Corp
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Filing: 1984-10-29
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Granted: 1988-05-31
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Expires: 2004-10-29
Abstract
Abstract Improved methods of ionophoretic drug delivery are described. By the intentional selection of drug(s) with specific characteristics, of ionotophoresis device, components or both permits the efficiency of drug delivery is increased.
Inventors
- 👤 Joseph B. Phipps
- 👤 Darrel F. Untereker
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 23:27
CPC Classifications
A; A61; A61N; A61N1/00; A61N1/02; A61N1/04; A61N1/0404; A61N1/0408; A61N1/0428; A61N1/0448; A61N1/0432; A61N1/0436; A61N1/0444
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
66 words
An improved method of iontophoretic drug delivery wherein an electrochemically active component of either the anode or the cathode of the iontophoresis device is intentionally comprised of a material that effets oxidation/reduction without being consumed to produce a species which interacts with an intentionally selected drug in which a corresponding weak acid/weak base form is selected to be delivered, so that water hydrolysis products are minimized.
Claim 2
Dependent Claim
66 words
An improved method of iontophoretic drug delivery wherein an electrochemically active component of either the anode or the cathode of the iontophoresis device is intentionally comprised of a material that effets oxidation/reduction without being consumed to produce a species which interacts with an intentionally selected drug in which a corresponding weak acid/weak base form is selected to be delivered, so that water hydrolysis products are minimized.
Claim 3
Dependent Claim
37 words
A method according to claim 1 wherein the electrochemically active component effects oxidation/reduction without being consumed and a corresponding weak acid/weak base form to be delivered is selected, whereby a neutral species is produced in the device.
Claim 4
Dependent Claim
14 words
A method according to claim 1 wherein the electrochemically active component comprises stainless steel.
Claim 5
Dependent Claim
13 words
A method according to claim 1 wherein the electrochemically active component comprises platinum.
Claim 6
Dependent Claim
19 words
A method according to claim 1 wherein the weak acid form of the drug to be delivered is DH.
Claim 7
Dependent Claim
16 words
A method according to claim 1 wherein the weak base form of the drug is DOH.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-05-31 | 1991-11-30 | 1992-05-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-05-31 | 1995-11-30 | 1996-05-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-05-31 | 1999-11-30 | 2000-05-31 | $7700.00 | Window Closed / Lapsed |