US4415563A
Expired / Lapsed
US
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Vehicle composition containing 1-substituted azacyclononan-2-ones
Assignee: Whitby Research Inc
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Filing: 1981-12-07
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Granted: 1983-11-15
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Expires: 2001-12-07
Abstract
Abstract Compositions useful for carrying physiologically active agents such as therapeutic agents through skin and other body membranes comprising the agent and an effective, non-toxic amount of a compound having the structural formula ##STR1## wherein R' is H or a lower alkyl group, m is 3-7, N is 0-17 and R is --CH 3 , phenyl or substituted phenyl or ##STR2## with the proviso that if m is 3 and R is --CH 3 , then n is not 0-6.
Inventors
- 👤 Vithal J. Rajadhyaksha
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 03:48
CPC Classifications
A; A61; A61K; A61K47/00; A61K47/06; A61K47/22; A61K9/00; A61K9/0012; A61K9/0014
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
55 words
A composition useful for topically administering a physiologically active agent to a human or animal comprising an effective amount of a physiologically active agent and a nontoxic, effective penetrating amount of a compound having the structural formula ##STR31## wherein n is 0-11 and R' is H or a lower alkyl group having 1-4 carbon atoms.
Claim 2
Dependent Claim
55 words
A composition useful for topically administering a physiologically active agent to a human or animal comprising an effective amount of a physiologically active agent and a nontoxic, effective penetrating amount of a compound having the structural formula ##STR31## wherein n is 0-11 and R' is H or a lower alkyl group having 1-4 carbon atoms.
Claim 3
Dependent Claim
14 words
The composition of claim 1 wherein the physiologically active agent is an antibacterial agent.
Claim 4
Dependent Claim
12 words
The composition of claim 2 wherein the antibacterial agent is an antibiotic.
Claim 5
Dependent Claim
23 words
The composition of claim 3 wherein the antibiotic is selected from the group consisting of lincomycin, clindamycin, erthromycin and pharmaceutically useful salts thereof.
Claim 6
Dependent Claim
15 words
The composition of claim 1 wherein the physiologically active agent is a physiologically active steroid.
Claim 7
Dependent Claim
14 words
The composition of claim 1 wherein the physiologically active agent is an antifungal agent.
Claim 8
Dependent Claim
12 words
The composition of claim 1 wherein the physiologically active agent is iododeoxyuridine.
Claim 9
Dependent Claim
12 words
The composition of claim 1 wherein the physiologically active agent is 5-fluorouracil.
Claim 10
Dependent Claim
53 words
A composition comprising an effective amount of a physiologically active agent and an effective, penetrating amount of a compound having the structural formula ##STR32## wherein R' is H or a lower alkyl group having 1-4 carbon atoms, n is 0-17 and R is --CH 3 or ##STR33## where R" is H or halagen.
Claim 11
Dependent Claim
53 words
A composition comprising an effective amount of a physiologically active agent and an effective, penetrating amount of a compound having the structural formula ##STR32## wherein R' is H or a lower alkyl group having 1-4 carbon atoms, n is 0-17 and R is --CH 3 or ##STR33## where R" is H or halagen.
Claim 12
Dependent Claim
41 words
A composition for topically administering a physiologically active agent to a human or animal comprising an effective amount of a physiologically active agent and a non-toxic, effective penetrating amount of a compound selected from the group consisting of 1-n-butylazacyclononan-2-one, and 1-n-octylazacyclononan-2-one.
Claim 13
Dependent Claim
41 words
A composition for topically administering a physiologically active agent to a human or animal comprising an effective amount of a physiologically active agent and a non-toxic, effective penetrating amount of a compound selected from the group consisting of 1-n-butylazacyclononan-2-one, and 1-n-octylazacyclononan-2-one.
Claim 14
Dependent Claim
28 words
A composition comprising an effective amount of a physiologically active agent and an effective, penetrating amount of a compound selected from the group consisting of 1-n-butylazacyclononan-2-one and 1-n-octylazacyclononan-2-one.
Claim 15
Dependent Claim
28 words
A composition comprising an effective amount of a physiologically active agent and an effective, penetrating amount of a compound selected from the group consisting of 1-n-butylazacyclononan-2-one and 1-n-octylazacyclononan-2-one.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-11-14 | 1987-05-16 | 1987-11-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-11-14 | 1991-05-16 | 1991-11-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-11-14 | 1995-05-16 | 1995-11-15 | $7700.00 | Window Closed / Lapsed |