US5221254A
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Method for reducing sensation in iontophoretic drug delivery
Assignee: Alza Corp
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Filing: 1991-04-02
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Granted: 1993-06-22
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Expires: 2011-04-02
Abstract
Abstract Methods for delivering therapeutic agents by iontophoresis with reduced or mitigated sensation are disclosed. The methods generally involve the step of delivering therapeutic agent by iontophoresis in the presence of an intentionally added sensation reducing amount of a multivalent ion. Preferred multivalent ions useful to mitigate sensation are calcium, magnesium, phosphate and zinc.
Inventors
- 👤 J. Bradley Phipps
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 22:43
CPC Classifications
A; A61; A61N; A61N1/00; A61N1/18; A61N1/20; A61N1/30
Claims Analysis
Total Claims: 30
Claim 1
Independent Claim
45 words
A method of reducing sensation in the iontophoretic delivery of a therapeutic agent through skin, the method comprising the step of: a. delivering by iontophoresis the therapeutic agent and a sensation reducing amount of an intentionally selected, physiologically acceptable, multivalent ion other than the agent.
Claim 2
Independent Claim
45 words
A method of reducing sensation in the iontophoretic delivery of a therapeutic agent through skin, the method comprising the step of: a. delivering by iontophoresis the therapeutic agent and a sensation reducing amount of an intentionally selected, physiologically acceptable, multivalent ion other than the agent.
Claim 3
Dependent Claim
12 words
A method according to claim 1 wherein the multivalent ion is divalent.
Claim 4
Dependent Claim
12 words
A method according to claim 1 wherein the multivalent ion is positive.
Claim 5
Dependent Claim
14 words
A method according to claim 1 wherein the multivalent ion is divalent and positive.
Claim 6
Dependent Claim
22 words
A method according to claim 1 wherein the multivalent ion is selected from the group consisting of calcium, zinc, magnesium, and phosphate.
Claim 7
Independent Claim
114 words
A method of reducing sensation in the iontophoresis delivery of drug through skin employing an iontophoretic delivery device having a power source, an electrode assembly electrically coupled to the power source and having a reservoir containing an agent to be delivered, the method comprising the steps of: a. intentionally adding a sensation reducing amount of a physiologically acceptable, multivalent ion to the reservoir of the electrode assembly; b. placing the electrode assembly containing the drug and multivalent ion in ion transmitting relationship with a skin surface capable of experiencing sensation; and c. delivering the drug and the multivalent ion from the device, the multivalent ion being delivered at a rate sufficient to reduce sensation.
Claim 8
Independent Claim
114 words
A method of reducing sensation in the iontophoresis delivery of drug through skin employing an iontophoretic delivery device having a power source, an electrode assembly electrically coupled to the power source and having a reservoir containing an agent to be delivered, the method comprising the steps of: a. intentionally adding a sensation reducing amount of a physiologically acceptable, multivalent ion to the reservoir of the electrode assembly; b. placing the electrode assembly containing the drug and multivalent ion in ion transmitting relationship with a skin surface capable of experiencing sensation; and c. delivering the drug and the multivalent ion from the device, the multivalent ion being delivered at a rate sufficient to reduce sensation.
Claim 9
Dependent Claim
21 words
The method of claim 6, wherein the multivalent ion is selected from the group consisting of calcium, zinc, magnesium, and phosphate.
Claim 10
Independent Claim
87 words
A method of reducing sensation of an electrical current in the iontophoretic delivery of drug employing an iontophoretic delivery device having a power source, an electrode assembly coupled to the power source and having a reservoir adapted to contain an agent to be delivered, the method comprising the steps of: a. intentionally adding a sensation reducing amount of calcium ion to the reservoir; and b. delivering drug with reduced sensation by virtue of the presence of calcium ion in the drug and calcium ion iontophoretically delivery process.
Claim 11
Independent Claim
87 words
A method of reducing sensation of an electrical current in the iontophoretic delivery of drug employing an iontophoretic delivery device having a power source, an electrode assembly coupled to the power source and having a reservoir adapted to contain an agent to be delivered, the method comprising the steps of: a. intentionally adding a sensation reducing amount of calcium ion to the reservoir; and b. delivering drug with reduced sensation by virtue of the presence of calcium ion in the drug and calcium ion iontophoretically delivery process.
Claim 12
Independent Claim
105 words
A method of reducing sensation of electrical current in the iontophoretic delivery of drugs through the skin of a patient, the method of comprising the steps of: a. providing an iontophoresis drug delivery apparatus comprising a power source, an electrode assembly electrically coupled to the power source having a reservoir containing an agent to be iontophoretically delivered; b. intentionally adding an amount of a physiologically acceptable multivalent ion to the apparatus reservoir sufficient to reduce sensation during drug delivery; c. placing the apparatus in contact with a patient's skin; and d. activating the device to deliver drug and said multivalent ion iontophoretically with reduced sensation.
Claim 13
Independent Claim
105 words
A method of reducing sensation of electrical current in the iontophoretic delivery of drugs through the skin of a patient, the method of comprising the steps of: a. providing an iontophoresis drug delivery apparatus comprising a power source, an electrode assembly electrically coupled to the power source having a reservoir containing an agent to be iontophoretically delivered; b. intentionally adding an amount of a physiologically acceptable multivalent ion to the apparatus reservoir sufficient to reduce sensation during drug delivery; c. placing the apparatus in contact with a patient's skin; and d. activating the device to deliver drug and said multivalent ion iontophoretically with reduced sensation.
Claim 14
Dependent Claim
12 words
A method according to claim 9 wherein the multivalent ion is divalent.
Claim 15
Dependent Claim
12 words
A method according to claim 9 wherein the multivalent ion is positive.
Claim 16
Dependent Claim
14 words
A method according to claim 9 wherein the multivalent ion is positive and divalent.
Claim 17
Dependent Claim
21 words
A method according to claim 9 wherein the multivalent ion is selected from the group consisting of calcium, zinc and phosphate.
Claim 18
Independent Claim
87 words
A method of reducing sensation in the iontophoretic delivery of a therapeutic agent during a bolus period starting a few seconds, to several minutes after the start of electrically-assisted administration of a therapeutic agent to a patient, the method comprising: a. providing a therapeutic agent for delivery; b. adding a sensation reducing amount of intentionally added multivalent ion other than the agent; c. delivering by iontophoresis the therapeutic agent and the a sensation reducing amount of the intentionally added, physiologically acceptable multivalent ion other than the agent.
Claim 19
Independent Claim
87 words
A method of reducing sensation in the iontophoretic delivery of a therapeutic agent during a bolus period starting a few seconds, to several minutes after the start of electrically-assisted administration of a therapeutic agent to a patient, the method comprising: a. providing a therapeutic agent for delivery; b. adding a sensation reducing amount of intentionally added multivalent ion other than the agent; c. delivering by iontophoresis the therapeutic agent and the a sensation reducing amount of the intentionally added, physiologically acceptable multivalent ion other than the agent.
Claim 20
Dependent Claim
42 words
A method according to claim 14 wherein the divalent ion is present in sufficient quantity so as to be depleted by the iontophoretic delivery process during the time period from the start of the delivery of agent until about 60 minutes thereafter.
Claim 21
Dependent Claim
26 words
A method according to claim 14 wherein the divalent ion is present in sufficient quantity so as to be depleted in about 5 to 20 minutes.
Claim 22
Dependent Claim
12 words
A method according to claim 14 wherein the multivalent ion is divalent.
Claim 23
Dependent Claim
12 words
A method according to claim 14 wherein the multivalent ion is positive.
Claim 24
Dependent Claim
14 words
A method according to claim 14 wherein the multivalent ion is divalent and positive.
Claim 25
Dependent Claim
22 words
A method according to claim 14 wherein the multivalent ion is selected from the group consisting of calcium, zinc, magnesium, and phosphate.
Claim 26
Independent Claim
123 words
A method of reducing sensation in the iontophoresis delivery of drug through skin employing an iontophoretic delivery device having a power source, an electrode assembly electrically coupled to the power source, the electrode assembly comprising a plurality of electrodes, the method comprising the steps of: a. intentionally adding a sensation reducing amount of a physiologically acceptable, multivalent ion to at least one of said electrodes; b. adding therapeutic drug to at least one of said electrodes; c. placing the electrode assembly containing the drug and multivalent ion in ion transmitting relationship with a skin surface capable of experiencing sensation; and d. delivering the drug and the multivalent ion from the device, the multivalent ion being delivered at a rate sufficient to reduce sensation.
Claim 27
Independent Claim
123 words
A method of reducing sensation in the iontophoresis delivery of drug through skin employing an iontophoretic delivery device having a power source, an electrode assembly electrically coupled to the power source, the electrode assembly comprising a plurality of electrodes, the method comprising the steps of: a. intentionally adding a sensation reducing amount of a physiologically acceptable, multivalent ion to at least one of said electrodes; b. adding therapeutic drug to at least one of said electrodes; c. placing the electrode assembly containing the drug and multivalent ion in ion transmitting relationship with a skin surface capable of experiencing sensation; and d. delivering the drug and the multivalent ion from the device, the multivalent ion being delivered at a rate sufficient to reduce sensation.
Claim 28
Dependent Claim
18 words
A method according to claim 21 wherein the drug and the multivalent ion are added to different electrodes.
Claim 29
Dependent Claim
19 words
A method according to claim 21 wherein the drug and the multivalent ion are added to the same electrode.
Claim 30
Dependent Claim
25 words
A method according to claim 21 wherein the multivalent ion is selected from the group consisting of calcium, zinc, magnesium, or phosphate or mixtures thereof.
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